We are analyzing https://link.springer.com/article/10.1007/s12602-021-09903-3.

Title:
Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities | Probiotics and Antimicrobial Proteins
Description:
The significance of diversity, composition, and functional attributes of the gut microbiota in shaping human health is well recognized. Studies have shown that gut microbiota is closely linked to human aging, and changes in the gut microbiome can predict human survival and longevity. In addition, a causal relationship between gut microbiota dysbiosis and chronic age-related disorders is also becoming apparent. Recent advances in our understanding of the cellular and molecular aspects of biological aging have revealed a cellular senescence-centric view of the aging process. However, the association between the gut microbiome and cellular senescence is only beginning to be understood. The present review provides an integrative view of the evolving relationship between the gut microbiome and cellular senescence in aging and disease. Evidence relating to microbiome-mediated modulation of senescent cells, as well as senescent cells-mediated changes in intestinal homeostasis and diseases, have been discussed. Unanswered questions and future research directions have also been deliberated to truly ascertain the relationship between the gut microbiome and cellular senescence for developing microbiome-based age-delaying and longevity-promoting therapies. Graphical abstract
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, cas, central, gut, aging, microbiota, microbiome, senescence, httpsdoiorgs, cell, sci, cellular, cells, human, mice, wang, sharma, zhang, senescent, chen, disease, ageing, intestinal, immune, nature, liu, nat, res, med, kim, cancer, dysbiosis, van, httpsdoiorg, age, kirkland, zhao, biol, rep, aged, agerelated, microbiol, healthy, tchkonia, zhu, composition, patients,

Topics {✒️}

uk/pa/ld5801/ldselect/ldsctech/183/183 suppressing ros-akt-mtor axis month download article/chapter developing microbiome-based age-delaying appears b7-h1-dependent h2o2-induced premature senescence pi3k/akt/mtor pathway g-protein-coupled receptor nutraceuticals-based immunotherapeutic concepts p53-dependent cellular senescence cell-free culture supernatant high-fiber diet protects functional redundancy-induced stability citrobacter rodentium-infected mice th1/th2 immune homeostasis attenuates colitis severity de’angelisrabot ns hla-e-mediated nk full article pdf cellular senescence-centric view gut microbiota-derived metabolites anti-obesity effects peripheral blood t-cells van deursen jm reactive oxygen species chronic age-related disorders article sharma article probiotics oxi-inflammatory stress privacy choices/manage cookies healthy ukrainian population microbial stimulation reverses age-related colitis healthy middle-aged phytochemical epigallocatechin gallate di cesare ml restores physical function van de sluis slee-valentijn ms future research directions age-dependent decline senescence-induced senescence central regulators burton jp antimicrobial proteins aims baker dj vegetable juices fermented germ-free mice increased cellular senescence intestinal epithelial barrier

Questions {❓}

Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM (2014) Senescence and apoptosis: dueling or complementary cell fates?

Schema {🗺️}

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