We are analyzing https://link.springer.com/article/10.1007/s12307-015-0174-x.

Title:
Characterization of M1/M2 Tumour-Associated Macrophages (TAMs) and Th1/Th2 Cytokine Profiles in Patients with NSCLC | Cancer Microenvironment
Description:
Lung cancer is one of the most commonly reported cancers, and is known to be associated with a poor prognosis. The function of tumour-associated macrophages (TAMs) in lung cancer patients is multifaceted and the literature shows conflicting roles. (I) To analyze the Th1 and Th2 cytokine levels that contribute to the differentiation of M1 and M2 macrophage populations in the serum of patients with NSCLC versus non-cancer controls; and (II) To characterize the M1 and M2 macrophage populations within TAMs in different subtypes of NSCLC compared to non-tumour tissue. The Th1 and Th2 cytokine levels were analyzed in serum using the Bio-Plex assay. In addition, TAMs subsets from non-tumour and tumour tissues were analyzed using immunohistochemistry (IHC). The level of IL-1β, IL-4, IL-6 and IL-8 was found to be increased in the serum of patients with large cell carcinoma but not in other NSCLC subtypes compared to non-cancer controls. In addition, the expression of CD68 and M2 marker CD163 was found to be increased (P ≤ 0.0001) in all NSCLC subtypes compared to non-tumour tissues. In contrast, the expression of iNOS (M1 marker) was decreased in the tumour tissue of patients with adenocarcinoma (P ≤ 0.01) and squamous carcinoma (P ≤ 0.05) but not in large cell carcinoma compared to non-tumour tissue. The results of this study indicate that NSCLC might have the ability to alter phenotype within the lung tumour areas in the local environment (TAMs) but not in the bloodstream in the systemic environment (serum) except for large cell carcinoma.
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Keywords {🔍}

article, pubmed, cancer, google, scholar, cas, lung, macrophages, cell, tumor, macrophage, patients, nonsmall, tumorassociated, central, clin, nsclc, human, tumour, immunol, cytokine, expression, microenvironment, carcinoma, res, cells, oncol, int, interleukin, tams, serum, tissue, access, chen, angiogenesis, progression, privacy, cookies, content, tumourassociated, almatroodi, prognosis, phenotype, factor, sica, survival, doi, function, publish, research,

Topics {✒️}

tumor necrosis factor-alpha month download article/chapter small-cell lung cancer enhanced irf-3/stat1 activation gender-specific cytokine pathways article cancer microenvironment full article pdf th1/th2 cytokine profiles interleukin-6 receptor suppresses lung tumour areas privacy choices/manage cookies large cell carcinoma human lung cancer lung carcinomas decrease mast-cell invasion m1/m2 tumour blood monocyte phenotype nsclc tumour islets related subjects common human cancers m2-polarized tumor brain tumour progression lung cancer patients european economic area commonly reported cancers bio-plex assay potential therapeutic strategy oude egbrink mg dwyer-nield ld distinct molecular mechanisms tnm staging system potential imaging pitfalls defective nf-kappab altered tumoricidal capacity adaptive antitumor immunity jnk1-dependent inflammation bronchoalveolar lavage fluid human macrophage metalloelastase bmc cancer 10 m2 macrophage populations tumor immune microenvironment conditions privacy policy monocyte/macrophage infiltration tumor-bearing mice tumor-host interactions produce tnf-[alpha] autologous peripheral monocytes circulating human interleukin-8 article log human alveolar macrophages

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      description:Lung cancer is one of the most commonly reported cancers, and is known to be associated with a poor prognosis. The function of tumour-associated macrophages (TAMs) in lung cancer patients is multifaceted and the literature shows conflicting roles. (I) To analyze the Th1 and Th2 cytokine levels that contribute to the differentiation of M1 and M2 macrophage populations in the serum of patients with NSCLC versus non-cancer controls; and (II) To characterize the M1 and M2 macrophage populations within TAMs in different subtypes of NSCLC compared to non-tumour tissue. The Th1 and Th2 cytokine levels were analyzed in serum using the Bio-Plex assay. In addition, TAMs subsets from non-tumour and tumour tissues were analyzed using immunohistochemistry (IHC). The level of IL-1β, IL-4, IL-6 and IL-8 was found to be increased in the serum of patients with large cell carcinoma but not in other NSCLC subtypes compared to non-cancer controls. In addition, the expression of CD68 and M2 marker CD163 was found to be increased (P ≤ 0.0001) in all NSCLC subtypes compared to non-tumour tissues. In contrast, the expression of iNOS (M1 marker) was decreased in the tumour tissue of patients with adenocarcinoma (P ≤ 0.01) and squamous carcinoma (P ≤ 0.05) but not in large cell carcinoma compared to non-tumour tissue. The results of this study indicate that NSCLC might have the ability to alter phenotype within the lung tumour areas in the local environment (TAMs) but not in the bloodstream in the systemic environment (serum) except for large cell carcinoma.
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