We are analyzing https://link.springer.com/article/10.1007/s12307-011-0069-4.

Title:
Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts | Cancer Microenvironment
Description:
Depending on the cell type and tissue environment, epithelial and mesenchymal cell phenotypes are not static and can be highly dynamic. Epithelial-mesenchymal transitions (EMTs) and reverse EMTs provide flexibility during embryogenesis. While EMTs are a critical normal process during development and wound healing, properties of the EMT have been implicated in human pathology, particularly cancer metastasis. A normal undamaged epithelium does not typically exhibit features of an EMT. However, particularly under the influence of the surrounding microenvironment, cancer cells may reactivate developmental phenotypes out of context in the adult. This reactivation, such as the EMT, can facilitate tumor cell invasion and metastasis, and therefore is a major mechanism of tumor progression. Conversely, cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, thereby constituting a potent tumor suppressive mechanism. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into pro-inflammatory cells having the ability to promote tumor progression, in part by inducing an EMT in nearby epithelial cells. Here, we summarize the potential impacts of SASP factors, particularly interleukins, on tissue microenvironments and their ability to stimulate tumor progression through induction of an EMT.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

article, google, scholar, pubmed, cas, cancer, cell, senescence, cells, tumor, biol, fibroblasts, epithelialmesenchymal, res, transition, human, senescent, cellular, microenvironment, progression, aging, growth, access, breast, nature, rev, epithelial, emt, metastasis, nat, privacy, cookies, content, research, campisi, tissue, senescenceassociated, mol, coppe, usa, publish, search, june, pierreyves, desprez, normal, invasion, secretory, sasp, open,

Topics {✒️}

ras-raf-mek-erk signaling pathway epithelial-mesenchymal transition induced epithelial-mesenchymal transition biomarkers month download article/chapter epithelial-mesenchymal transition mesenchymal-epithelial transition pierre-yves desprez dna damage-mediated induction nf-kappab-dependent manner epithelial-mesenchymal transitions tumor-promoting cell type mesenchymal cell phenotypes orchestrate tumor-promoting inflammation full article pdf human breast cancer—observations related subjects ets1 transcription factor oncogene-induced senescence increases migration radiation-induced increase stem cells nearby epithelial cells privacy choices/manage cookies stromal-epithelial interactions therapy-induced senescence breast tissue microenvironment primary human fibroblasts promote tumor progression article laberge tumor cell interactions reactivate developmental phenotypes mouse cells dependent turns senescent fibroblasts tumor-stromal interactions tumor suppressor maspin telomere-initiated senescence pancreatic cancer cells human intervertebral discs human life-spans cellular proliferation p53 tumor suppressor european economic area normal undamaged epithelium typically exhibit features check access adda di fagagna limiting cartilage repair bone joint surg matrix metalloproteinase inhibitor rate-limiting step

Questions {❓}

Dimri GP (2005) What has senescence got to do with cancer?
Homey B, Muller A, Zlotnik A (2002) Chemokines: agents for the immunotherapy of cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts
         description:Depending on the cell type and tissue environment, epithelial and mesenchymal cell phenotypes are not static and can be highly dynamic. Epithelial-mesenchymal transitions (EMTs) and reverse EMTs provide flexibility during embryogenesis. While EMTs are a critical normal process during development and wound healing, properties of the EMT have been implicated in human pathology, particularly cancer metastasis. A normal undamaged epithelium does not typically exhibit features of an EMT. However, particularly under the influence of the surrounding microenvironment, cancer cells may reactivate developmental phenotypes out of context in the adult. This reactivation, such as the EMT, can facilitate tumor cell invasion and metastasis, and therefore is a major mechanism of tumor progression. Conversely, cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, thereby constituting a potent tumor suppressive mechanism. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into pro-inflammatory cells having the ability to promote tumor progression, in part by inducing an EMT in nearby epithelial cells. Here, we summarize the potential impacts of SASP factors, particularly interleukins, on tissue microenvironments and their ability to stimulate tumor progression through induction of an EMT.
         datePublished:2011-06-25T00:00:00Z
         dateModified:2011-06-25T00:00:00Z
         pageStart:39
         pageEnd:44
         sameAs:https://doi.org/10.1007/s12307-011-0069-4
         keywords:
            Aging
            Senescence
            Cytokines
            Interleukins
            Proliferation
            Invasion
            Migration
            Cancer Research
            Oncology
            Immunology
            Cell Biology
            Biochemistry
            general
            Biomedicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12307-011-0069-4/MediaObjects/12307_2011_69_Fig1_HTML.gif
         isPartOf:
            name:Cancer Microenvironment
            issn:
               1875-2284
               1875-2292
            volumeNumber:5
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Remi-Martin Laberge
               affiliation:
                     name:Buck Institute for Research on Aging
                     address:
                        name:Buck Institute for Research on Aging, Novato, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pierre Awad
               affiliation:
                     name:Buck Institute for Research on Aging
                     address:
                        name:Buck Institute for Research on Aging, Novato, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Judith Campisi
               affiliation:
                     name:Buck Institute for Research on Aging
                     address:
                        name:Buck Institute for Research on Aging, Novato, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pierre-Yves Desprez
               affiliation:
                     name:Buck Institute for Research on Aging
                     address:
                        name:Buck Institute for Research on Aging, Novato, USA
                        type:PostalAddress
                     type:Organization
                     name:California Pacific Medical Center, Research Institute
                     address:
                        name:California Pacific Medical Center, Research Institute, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts
      description:Depending on the cell type and tissue environment, epithelial and mesenchymal cell phenotypes are not static and can be highly dynamic. Epithelial-mesenchymal transitions (EMTs) and reverse EMTs provide flexibility during embryogenesis. While EMTs are a critical normal process during development and wound healing, properties of the EMT have been implicated in human pathology, particularly cancer metastasis. A normal undamaged epithelium does not typically exhibit features of an EMT. However, particularly under the influence of the surrounding microenvironment, cancer cells may reactivate developmental phenotypes out of context in the adult. This reactivation, such as the EMT, can facilitate tumor cell invasion and metastasis, and therefore is a major mechanism of tumor progression. Conversely, cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, thereby constituting a potent tumor suppressive mechanism. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into pro-inflammatory cells having the ability to promote tumor progression, in part by inducing an EMT in nearby epithelial cells. Here, we summarize the potential impacts of SASP factors, particularly interleukins, on tissue microenvironments and their ability to stimulate tumor progression through induction of an EMT.
      datePublished:2011-06-25T00:00:00Z
      dateModified:2011-06-25T00:00:00Z
      pageStart:39
      pageEnd:44
      sameAs:https://doi.org/10.1007/s12307-011-0069-4
      keywords:
         Aging
         Senescence
         Cytokines
         Interleukins
         Proliferation
         Invasion
         Migration
         Cancer Research
         Oncology
         Immunology
         Cell Biology
         Biochemistry
         general
         Biomedicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12307-011-0069-4/MediaObjects/12307_2011_69_Fig1_HTML.gif
      isPartOf:
         name:Cancer Microenvironment
         issn:
            1875-2284
            1875-2292
         volumeNumber:5
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Remi-Martin Laberge
            affiliation:
                  name:Buck Institute for Research on Aging
                  address:
                     name:Buck Institute for Research on Aging, Novato, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pierre Awad
            affiliation:
                  name:Buck Institute for Research on Aging
                  address:
                     name:Buck Institute for Research on Aging, Novato, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Judith Campisi
            affiliation:
                  name:Buck Institute for Research on Aging
                  address:
                     name:Buck Institute for Research on Aging, Novato, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pierre-Yves Desprez
            affiliation:
                  name:Buck Institute for Research on Aging
                  address:
                     name:Buck Institute for Research on Aging, Novato, USA
                     type:PostalAddress
                  type:Organization
                  name:California Pacific Medical Center, Research Institute
                  address:
                     name:California Pacific Medical Center, Research Institute, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer Microenvironment
      issn:
         1875-2284
         1875-2292
      volumeNumber:5
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Buck Institute for Research on Aging
      address:
         name:Buck Institute for Research on Aging, Novato, USA
         type:PostalAddress
      name:Buck Institute for Research on Aging
      address:
         name:Buck Institute for Research on Aging, Novato, USA
         type:PostalAddress
      name:Buck Institute for Research on Aging
      address:
         name:Buck Institute for Research on Aging, Novato, USA
         type:PostalAddress
      name:Buck Institute for Research on Aging
      address:
         name:Buck Institute for Research on Aging, Novato, USA
         type:PostalAddress
      name:California Pacific Medical Center, Research Institute
      address:
         name:California Pacific Medical Center, Research Institute, San Francisco, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Remi-Martin Laberge
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
      name:Pierre Awad
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
      name:Judith Campisi
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
      name:Pierre-Yves Desprez
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
            name:California Pacific Medical Center, Research Institute
            address:
               name:California Pacific Medical Center, Research Institute, San Francisco, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Buck Institute for Research on Aging, Novato, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:California Pacific Medical Center, Research Institute, San Francisco, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(211)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.26s.

LINK . SPRINGER . COM {}