We are analyzing https://link.springer.com/article/10.1007/s12307-008-0005-4.

Title:
Significance of Toll-like Receptors Expression in Tumor Growth and Spreading: A Short Review | Cancer Microenvironment
Description:
Toll-like receptors (TLRs) are considered now as crucial sensors of innate immunity. Their role in the recognition of pathogens and the initiation of adaptive immune responses against them is well known. However, in last years TLRs have been identified on several tumor cells, including human malignancies. Their expression in cancer was found to be twofold: either promoting or inhibiting tumor progression. It was also demonstrated that several TLRs agonists, either natural or synthetic ones, may have beneficial effect on tumor-mediated disease, leading to potentiation of immune response to tumor-associated antigens. TLR-agonist linked tumor immunotherapy is still in nascent state, but growing rapidly, also in the area of common human malignancies. To date, the most promising and the most frequently studied interaction in tumor immunotherapy trials seems to be TLR9 and its synthetic agonists.
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Keywords {🔍}

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Topics {✒️}

mitogen-activated protein kinase myd88-independent/trif-dependent pathway toll-interacting protein—tollip article download pdf chronic lymphocytic leukemia inhibit myd88-related pathway tnf-alpha induced apoptosis phosphoinositide-3-kinase akt conventional anti-tumor therapies drug-mediated apoptosis [unpublished] tlr-mediated tumor immunotherapy tlr-mediated signaling induced conventional anti-cancer treatment macrophage activating lipopeptide-2 cancer cells secrete common human malignancies anti-cancer immunity il-1 receptor-associate kinases cell nucleus result privacy choices/manage cookies induce cell death extensive research programs human myeloma cells anti-cancer drug human tumor immunotherapy human cancer cells cell death due squamous cell carcinomas unmethylated cpg oligonucleotides tumor cell growth cell signaling mediated express functional toll article zeromski nk cell activity support tumor progression promote tumor growth future drugs targeting review article cell interior happening jan zeromski prostate epithelial cells myd88− cancer cells anti-tumor effect [27] related subjects innate immune response inducing immunosuppressive cytokines degraded tumor cells full access promote tumor progression cpg-oligonucleotides myd88

Questions {❓}

Killeen SD, Wang JH, Andrews EJ et al (2006) Exploitation of the toll-like receptor system in cancer: a doubled-edged sword?
Salaun B, Lebecque S, Matikainen S et al (2007) Toll-like receptor 3 expressed by melanoma cells as a target for therapy?

Schema {🗺️}

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         headline:Significance of Toll-like Receptors Expression in Tumor Growth and Spreading: A Short Review
         description:Toll-like receptors (TLRs) are considered now as crucial sensors of innate immunity. Their role in the recognition of pathogens and the initiation of adaptive immune responses against them is well known. However, in last years TLRs have been identified on several tumor cells, including human malignancies. Their expression in cancer was found to be twofold: either promoting or inhibiting tumor progression. It was also demonstrated that several TLRs agonists, either natural or synthetic ones, may have beneficial effect on tumor-mediated disease, leading to potentiation of immune response to tumor-associated antigens. TLR-agonist linked tumor immunotherapy is still in nascent state, but growing rapidly, also in the area of common human malignancies. To date, the most promising and the most frequently studied interaction in tumor immunotherapy trials seems to be TLR9 and its synthetic agonists.
         datePublished:2008-02-29T00:00:00Z
         dateModified:2008-02-29T00:00:00Z
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      headline:Significance of Toll-like Receptors Expression in Tumor Growth and Spreading: A Short Review
      description:Toll-like receptors (TLRs) are considered now as crucial sensors of innate immunity. Their role in the recognition of pathogens and the initiation of adaptive immune responses against them is well known. However, in last years TLRs have been identified on several tumor cells, including human malignancies. Their expression in cancer was found to be twofold: either promoting or inhibiting tumor progression. It was also demonstrated that several TLRs agonists, either natural or synthetic ones, may have beneficial effect on tumor-mediated disease, leading to potentiation of immune response to tumor-associated antigens. TLR-agonist linked tumor immunotherapy is still in nascent state, but growing rapidly, also in the area of common human malignancies. To date, the most promising and the most frequently studied interaction in tumor immunotherapy trials seems to be TLR9 and its synthetic agonists.
      datePublished:2008-02-29T00:00:00Z
      dateModified:2008-02-29T00:00:00Z
      pageStart:37
      pageEnd:42
      license:https://creativecommons.org/licenses/by-nc/2.0
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         Toll-like receptors
         Pathogen-associated molecular patterns
         Innate immunity
         Signaling
         Tumor cells
         Agonists
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         Oncology
         Immunology
         Cell Biology
         Biochemistry
         general
         Biomedicine
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