We are analyzing https://link.springer.com/article/10.1007/s12272-001-1280-8.

Title:
Structurally related cytotoxic effects of flavonoids on human cancer cells in vitro | Archives of Pharmacal Research
Description:
Flavonoids exist extensively in the human diet, and a variety of health effects have been ascribed to them. The cytotoxic effects of 23 flavonoids on breast cancer cells (MDA-MB-231 and MCF-7), colorectal carcinoma cells (LoVo and DLD-1) and prostatic cancer cells (PC3) were investigated. By comparing the cytotoxicity (EC50) of selected molecules that differ in only one structure element, we identified several structural properties associated with enhanced cytotoxicity, including the presence of the 2,3-double bond, appropriate hydroxyl numbers, 3-OH, 6-OH and ortho-hydroxylation in ring B. Flavonoids with a 5-OH exhibited lower cytotoxicity than their non-hydroxylated counterparts. Results indicated that 3,6-dihydroxylflavone showed the most potent cytotoxic effect on these cancer cells. The appearance of apoptotic cells with DAPI staining was observed in cancer cells under 3,6-dihydroxylflavone treatment, and the apoptosis analysis by flow cytometry also showed that 3,6-dihydroxylflavone induced apoptotic cell death in these cancer cells. These results revealed the structurally related toxicity of flavonoids on human cancer cells, and indicates that 3,6-dihydroxylflavone is an active compound worthy of development for cancer chemotherapy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, cancer, google, scholar, pubmed, cells, cas, flavonoids, cell, human, apoptosis, res, research, related, access, privacy, cookies, content, cytotoxic, effects, cytotoxicity, dihydroxylflavone, activity, inhibition, dietary, arch, pharm, kim, publish, search, structurally, vitro, ling, yong, induction, chen, prostate, data, information, log, journal, drug, april, chang, mantian, wenhua, health, breast, mcf, apoptotic,

Topics {✒️}

month download article/chapter cell cycle arrest potent cytotoxic effect modulating bcl-2-related proteins nonsteroidal flavone-methanesulfonate derivatives mcf-7 cell line 6-dihydroxylflavone pro-apoptosis access myeloma cell lines pharmacal research aims breast cancer cells cancer cell apoptosis structurally related toxicity full article pdf anti-inflammatory activity human cancer cells structure element privacy choices/manage cookies promising chemotherapeutic candidates human leukemia cells age-related variations apoptosis inducing activity related subjects mcf7 ras cells dietary compound luteolin prostatic cancer cells cytotoxic effects colorectal carcinoma cells european economic area active compound worthy monobenzyltin complex c1 van-der-vijgh acute lymphocytic leukemia rapid colorimetric assay article archives article chang prostate cancer risk mda-mb-231 cells conditions privacy policy military medical university apoptotic activity accepting optional cookies p21 gene expression exhibited lower cytotoxicity main content log cancer cells article log journal finder publish check access author correspondence instant access

Questions {❓}

, Dietary polyphenolic phytochemicals-promising cancer chemopreventive agents in humans?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Structurally related cytotoxic effects of flavonoids on human cancer cells in vitro
         description:Flavonoids exist extensively in the human diet, and a variety of health effects have been ascribed to them. The cytotoxic effects of 23 flavonoids on breast cancer cells (MDA-MB-231 and MCF-7), colorectal carcinoma cells (LoVo and DLD-1) and prostatic cancer cells (PC3) were investigated. By comparing the cytotoxicity (EC50) of selected molecules that differ in only one structure element, we identified several structural properties associated with enhanced cytotoxicity, including the presence of the 2,3-double bond, appropriate hydroxyl numbers, 3-OH, 6-OH and ortho-hydroxylation in ring B. Flavonoids with a 5-OH exhibited lower cytotoxicity than their non-hydroxylated counterparts. Results indicated that 3,6-dihydroxylflavone showed the most potent cytotoxic effect on these cancer cells. The appearance of apoptotic cells with DAPI staining was observed in cancer cells under 3,6-dihydroxylflavone treatment, and the apoptosis analysis by flow cytometry also showed that 3,6-dihydroxylflavone induced apoptotic cell death in these cancer cells. These results revealed the structurally related toxicity of flavonoids on human cancer cells, and indicates that 3,6-dihydroxylflavone is an active compound worthy of development for cancer chemotherapy.
         datePublished:2009-04-30T00:00:00Z
         dateModified:2009-04-30T00:00:00Z
         pageStart:1137
         pageEnd:1144
         sameAs:https://doi.org/10.1007/s12272-001-1280-8
         keywords:
            Flavonoids
            Cytotoxic effect
            Cancer cells
            Structure-activity relationship
            3,6-Dihydroxylflavone
            Pro-apoptosis
            Pharmacy
            Pharmacology/Toxicology
         image:
         isPartOf:
            name:Archives of Pharmacal Research
            issn:
               1976-3786
               0253-6269
            volumeNumber:31
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Pharmaceutical Society of Korea
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Hui Chang
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mantian Mi
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Wenhua Ling
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
                     name:Sun Yet-sen University
                     address:
                        name:Department of Nutrition, Public Health School, Sun Yet-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jundong Zhu
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qianyong Zhang
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Na Wei
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yong Zhou
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yong Tang
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jialin Yuan
               affiliation:
                     name:The Third Military Medical University
                     address:
                        name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Structurally related cytotoxic effects of flavonoids on human cancer cells in vitro
      description:Flavonoids exist extensively in the human diet, and a variety of health effects have been ascribed to them. The cytotoxic effects of 23 flavonoids on breast cancer cells (MDA-MB-231 and MCF-7), colorectal carcinoma cells (LoVo and DLD-1) and prostatic cancer cells (PC3) were investigated. By comparing the cytotoxicity (EC50) of selected molecules that differ in only one structure element, we identified several structural properties associated with enhanced cytotoxicity, including the presence of the 2,3-double bond, appropriate hydroxyl numbers, 3-OH, 6-OH and ortho-hydroxylation in ring B. Flavonoids with a 5-OH exhibited lower cytotoxicity than their non-hydroxylated counterparts. Results indicated that 3,6-dihydroxylflavone showed the most potent cytotoxic effect on these cancer cells. The appearance of apoptotic cells with DAPI staining was observed in cancer cells under 3,6-dihydroxylflavone treatment, and the apoptosis analysis by flow cytometry also showed that 3,6-dihydroxylflavone induced apoptotic cell death in these cancer cells. These results revealed the structurally related toxicity of flavonoids on human cancer cells, and indicates that 3,6-dihydroxylflavone is an active compound worthy of development for cancer chemotherapy.
      datePublished:2009-04-30T00:00:00Z
      dateModified:2009-04-30T00:00:00Z
      pageStart:1137
      pageEnd:1144
      sameAs:https://doi.org/10.1007/s12272-001-1280-8
      keywords:
         Flavonoids
         Cytotoxic effect
         Cancer cells
         Structure-activity relationship
         3,6-Dihydroxylflavone
         Pro-apoptosis
         Pharmacy
         Pharmacology/Toxicology
      image:
      isPartOf:
         name:Archives of Pharmacal Research
         issn:
            1976-3786
            0253-6269
         volumeNumber:31
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Pharmaceutical Society of Korea
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Hui Chang
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mantian Mi
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Wenhua Ling
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
                  name:Sun Yet-sen University
                  address:
                     name:Department of Nutrition, Public Health School, Sun Yet-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jundong Zhu
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qianyong Zhang
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Na Wei
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yong Zhou
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yong Tang
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jialin Yuan
            affiliation:
                  name:The Third Military Medical University
                  address:
                     name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Archives of Pharmacal Research
      issn:
         1976-3786
         0253-6269
      volumeNumber:31
Organization:
      name:Pharmaceutical Society of Korea
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:Sun Yet-sen University
      address:
         name:Department of Nutrition, Public Health School, Sun Yet-sen University, Guangzhou, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
      name:The Third Military Medical University
      address:
         name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Hui Chang
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Mantian Mi
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Wenhua Ling
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
            name:Sun Yet-sen University
            address:
               name:Department of Nutrition, Public Health School, Sun Yet-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Jundong Zhu
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Qianyong Zhang
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Na Wei
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Yong Zhou
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Yong Tang
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Jialin Yuan
      affiliation:
            name:The Third Military Medical University
            address:
               name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition, Public Health School, Sun Yet-sen University, Guangzhou, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
      name:Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(106)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.19s.

LINK . SPRINGER . COM {}