We are analyzing https://link.springer.com/article/10.1007/s12253-012-9500-5.

Title:
Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers | Pathology & Oncology Research
Description:
Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endometrial cancers GLUT1 and GLUT3 protein expression was identified in 67.1% and 30.3% of cases. Analogously, in breast cancers in 48.7% and 21% of samples, respectively. The results showed that both endometrial and breast poorly differentiated tumors (grade 2 and 3) had significantly higher GLUT1 and GLUT3 expression than well-differentiated tumors (grade 1). Statistically significant association was found between SLCA2A3 mRNA expression and estrogen and progesterone receptors status in breast cancers. GLUT1 has been reported to be involved in the uptake of glucose by endometrial and breast carcinoma cells earlier and the present study determined that GLUT3 expression is also involved. GLUT1 and GLUT3 seem to be important markers in endometrial and breast tumors differentiation.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Photography

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

glut, expression, breast, cancer, endometrial, glucose, mrna, article, cancers, protein, google, scholar, slca, grade, normal, carcinoma, tumors, gene, pubmed, samples, cas, results, table, showed, tissue, transporters, cells, carcinomas, cases, analysis, case, access, transporter, human, tumor, levels, size, clinicopathological, parameters, pcr, full, present, study, realtime, found, higher, significant, level, clinical, cancerous,

Topics {✒️}

full size image real-time pcr primers anti-mouse antibodies conjugated gel-pro® analyzer software real-time pcr mastercycler ep realplex post-hoc multiple comparisons copy number quantification article download pdf western blotting technique quantitative densitometric analysis rabbit polyclonal anti-glut1 katarzyna wojcik-krowiranda rt-qpcr reaction glut3 mrna/protein expression full access relative rna quantification glut1 mrna/protein expression privacy choices/manage cookies progesterone receptors status oligonucleotide microarray analysis slca2a3 mrna expression western blotting goat anti-rabbit breast cancer specimens positive gene expression slca2a3 mrnas expression article krzeslak slca2a3 mrna measured unlabeled pcr primers bmc cancer 9 post-hoc tests magdalena brys cancer cells compared breast carcinoma cells gene symbol slc2a protein expression level human breast carcinoma invasive ductal carcinoma lymph node metastasis breast cancer cases protein expression levels research institute glucose transporter family lane 2—endometrial carcinoma specific glucose transporters glucose transporters differ glucose transporters expression transporter protein possesses gene encoded glut3

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
         description:Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endometrial cancers GLUT1 and GLUT3 protein expression was identified in 67.1% and 30.3% of cases. Analogously, in breast cancers in 48.7% and 21% of samples, respectively. The results showed that both endometrial and breast poorly differentiated tumors (grade 2 and 3) had significantly higher GLUT1 and GLUT3 expression than well-differentiated tumors (grade 1). Statistically significant association was found between SLCA2A3 mRNA expression and estrogen and progesterone receptors status in breast cancers. GLUT1 has been reported to be involved in the uptake of glucose by endometrial and breast carcinoma cells earlier and the present study determined that GLUT3 expression is also involved. GLUT1 and GLUT3 seem to be important markers in endometrial and breast tumors differentiation.
         datePublished:2012-01-21T00:00:00Z
         dateModified:2012-01-21T00:00:00Z
         pageStart:721
         pageEnd:728
         license:https://creativecommons.org/licenses/by-nc/2.0
         sameAs:https://doi.org/10.1007/s12253-012-9500-5
         keywords:
            Glucose transporters
            mRNA expression
            Protein expression
            Breast cancer
            Endometrial cancer
            Cancer Research
            Oncology
            Pathology
            Immunology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12253-012-9500-5/MediaObjects/12253_2012_9500_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12253-012-9500-5/MediaObjects/12253_2012_9500_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12253-012-9500-5/MediaObjects/12253_2012_9500_Fig3_HTML.gif
         isPartOf:
            name:Pathology & Oncology Research
            issn:
               1532-2807
               1219-4956
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Anna Krzeslak
               affiliation:
                     name:University of Lodz
                     address:
                        name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Katarzyna Wojcik-Krowiranda
               affiliation:
                     name:Medical University of Lodz
                     address:
                        name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ewa Forma
               affiliation:
                     name:University of Lodz
                     address:
                        name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Paweł Jozwiak
               affiliation:
                     name:University of Lodz
                     address:
                        name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hanna Romanowicz
               affiliation:
                     name:Polish Mother’s Memorial Hospital Research Institute
                     address:
                        name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrzej Bienkiewicz
               affiliation:
                     name:Medical University of Lodz
                     address:
                        name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Magdalena Brys
               affiliation:
                     name:University of Lodz
                     address:
                        name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
      description:Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endometrial cancers GLUT1 and GLUT3 protein expression was identified in 67.1% and 30.3% of cases. Analogously, in breast cancers in 48.7% and 21% of samples, respectively. The results showed that both endometrial and breast poorly differentiated tumors (grade 2 and 3) had significantly higher GLUT1 and GLUT3 expression than well-differentiated tumors (grade 1). Statistically significant association was found between SLCA2A3 mRNA expression and estrogen and progesterone receptors status in breast cancers. GLUT1 has been reported to be involved in the uptake of glucose by endometrial and breast carcinoma cells earlier and the present study determined that GLUT3 expression is also involved. GLUT1 and GLUT3 seem to be important markers in endometrial and breast tumors differentiation.
      datePublished:2012-01-21T00:00:00Z
      dateModified:2012-01-21T00:00:00Z
      pageStart:721
      pageEnd:728
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s12253-012-9500-5
      keywords:
         Glucose transporters
         mRNA expression
         Protein expression
         Breast cancer
         Endometrial cancer
         Cancer Research
         Oncology
         Pathology
         Immunology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12253-012-9500-5/MediaObjects/12253_2012_9500_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12253-012-9500-5/MediaObjects/12253_2012_9500_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12253-012-9500-5/MediaObjects/12253_2012_9500_Fig3_HTML.gif
      isPartOf:
         name:Pathology & Oncology Research
         issn:
            1532-2807
            1219-4956
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Anna Krzeslak
            affiliation:
                  name:University of Lodz
                  address:
                     name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Katarzyna Wojcik-Krowiranda
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ewa Forma
            affiliation:
                  name:University of Lodz
                  address:
                     name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Paweł Jozwiak
            affiliation:
                  name:University of Lodz
                  address:
                     name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hanna Romanowicz
            affiliation:
                  name:Polish Mother’s Memorial Hospital Research Institute
                  address:
                     name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrzej Bienkiewicz
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Magdalena Brys
            affiliation:
                  name:University of Lodz
                  address:
                     name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Pathology & Oncology Research
      issn:
         1532-2807
         1219-4956
      volumeNumber:18
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Lodz
      address:
         name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
         type:PostalAddress
      name:University of Lodz
      address:
         name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
         type:PostalAddress
      name:University of Lodz
      address:
         name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Polish Mother’s Memorial Hospital Research Institute
      address:
         name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
         type:PostalAddress
      name:University of Lodz
      address:
         name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Anna Krzeslak
      affiliation:
            name:University of Lodz
            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Katarzyna Wojcik-Krowiranda
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Ewa Forma
      affiliation:
            name:University of Lodz
            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Paweł Jozwiak
      affiliation:
            name:University of Lodz
            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Hanna Romanowicz
      affiliation:
            name:Polish Mother’s Memorial Hospital Research Institute
            address:
               name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
               type:PostalAddress
            type:Organization
      name:Andrzej Bienkiewicz
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Magdalena Brys
      affiliation:
            name:University of Lodz
            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
      name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
      name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
      name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland

External Links {🔗}(108)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.86s.

LINK . SPRINGER . COM {}