We are analyzing https://link.springer.com/article/10.1007/s12192-017-0816-7.

Title:
SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress | Cell Stress and Chaperones
Description:
SG2NA belongs to a three-member striatin subfamily of WD40 repeat superfamily of proteins. It has multiple protein-protein interaction domains involved in assembling supramolecular signaling complexes. Earlier, we had demonstrated that there are at least five variants of SG2NA generated by alternative splicing, intron retention, and RNA editing. Such versatile and dynamic mode of regulation implicates it in tissue development. In order to shed light on its role in cell physiology, total proteome analysis was performed in NIH3T3 cells depleted of 78 kDa SG2NA, the only isoform expressing therein. A number of ER stress markers were among those modulated after knockdown of SG2NA. In cells treated with the ER stressors thapsigargin and tunicamycin, expression of SG2NA was increased at both mRNA and protein levels. The increased level of SG2NA was primarily in the mitochondria and the microsomes. A mouse injected with thapsigargin also had an increase in SG2NA in the liver but not in the brain. Cell cycle analysis suggested that while loss of SG2NA reduces the level of cyclin D1 and retains a population of cells in the G1 phase, concurrent ER stress facilitates their exit from G1 and traverse through subsequent phases with concomitant cell death. Thus, SG2NA is a component of intrinsic regulatory pathways that maintains ER homeostasis.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cell, protein, central, stress, sgna, biol, cells, endoplasmic, reticulum, striatin, stripak, jain, tanti, goswami, sci, chem, signaling, access, response, cancer, doijbcm, res, function, buddhi, pandey, death, kinase, phosphatase, unfolded, family, mol, zhang, india, university, privacy, cookies, content, analysis, prakash, repeat, proteins, complexes, role, cycle, human,

Topics {✒️}

matrix-assisted laser desorption/ionization-time month download article/chapter methamphetamine-mediated endoplasmic reticulum pi3k-akt-gsk3β signaling pathway 2-deoxy-d-glucose suppresses dna-binding nuclear autoantigen cell-cycle nuclear autoantigen article cell stress buddhi prakash jain k-ras-transformed cells endoplasmic reticulum stress related subjects thapsigargin-induced cell death endoplasmic reticulum dynamics protein factor-arrest 11 full article pdf cell-cycle progression cell cycle progression shalini mishra helped abd malek sn er stress markers measuring er stress inducing er stress protein disulfide isomerase calmodulin-binding proteins article jain maintains er homeostasis unfolded protein response protein interaction network compressive mechanical stress pro-apoptotic effects estrogen receptor alpha privacy choices/manage cookies protein phosphatase 2a concomitant cell death golgi complex striatin-interacting phosphatase cyclin d1 striatin-interacting phosphatases check access dna damage signaling instant access multiple splice variants wd40 repeat superfamily ternary wd40 repeat wd-40 motifs expressed hexosamine biosynthesis pathway leucine-rich repeat g2 phase cells genome integrity

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         headline:SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress
         description:SG2NA belongs to a three-member striatin subfamily of WD40 repeat superfamily of proteins. It has multiple protein-protein interaction domains involved in assembling supramolecular signaling complexes. Earlier, we had demonstrated that there are at least five variants of SG2NA generated by alternative splicing, intron retention, and RNA editing. Such versatile and dynamic mode of regulation implicates it in tissue development. In order to shed light on its role in cell physiology, total proteome analysis was performed in NIH3T3 cells depleted of 78 kDa SG2NA, the only isoform expressing therein. A number of ER stress markers were among those modulated after knockdown of SG2NA. In cells treated with the ER stressors thapsigargin and tunicamycin, expression of SG2NA was increased at both mRNA and protein levels. The increased level of SG2NA was primarily in the mitochondria and the microsomes. A mouse injected with thapsigargin also had an increase in SG2NA in the liver but not in the brain. Cell cycle analysis suggested that while loss of SG2NA reduces the level of cyclin D1 and retains a population of cells in the G1 phase, concurrent ER stress facilitates their exit from G1 and traverse through subsequent phases with concomitant cell death. Thus, SG2NA is a component of intrinsic regulatory pathways that maintains ER homeostasis.
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      headline:SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress
      description:SG2NA belongs to a three-member striatin subfamily of WD40 repeat superfamily of proteins. It has multiple protein-protein interaction domains involved in assembling supramolecular signaling complexes. Earlier, we had demonstrated that there are at least five variants of SG2NA generated by alternative splicing, intron retention, and RNA editing. Such versatile and dynamic mode of regulation implicates it in tissue development. In order to shed light on its role in cell physiology, total proteome analysis was performed in NIH3T3 cells depleted of 78 kDa SG2NA, the only isoform expressing therein. A number of ER stress markers were among those modulated after knockdown of SG2NA. In cells treated with the ER stressors thapsigargin and tunicamycin, expression of SG2NA was increased at both mRNA and protein levels. The increased level of SG2NA was primarily in the mitochondria and the microsomes. A mouse injected with thapsigargin also had an increase in SG2NA in the liver but not in the brain. Cell cycle analysis suggested that while loss of SG2NA reduces the level of cyclin D1 and retains a population of cells in the G1 phase, concurrent ER stress facilitates their exit from G1 and traverse through subsequent phases with concomitant cell death. Thus, SG2NA is a component of intrinsic regulatory pathways that maintains ER homeostasis.
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         SG2NA
         Striatin
         STRIPAK
         ER stress
         Cell cycle
         Biomedicine
         general
         Cell Biology
         Biochemistry
         Immunology
         Cancer Research
         Neurosciences
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