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Keywords {🔍}

cancer, bladder, article, molecular, real, privacy, cookies, content, francisco, alterations, access, information, publish, search, clinical, biology, tumors, data, log, journal, research, oncology, luis, lópezknowles, chapter, discover, author, barcelona, spain, springer, optional, personal, parties, policy, find, track, translational, educational, series, cite, nuno, elena, explore, types, identified, characterized, fgfr, chromosome, frequency, pathways,

Topics {✒️}

bladder cancer development month download article/chapter bladder cancer elena lópez-knowles & francisco translational oncology aims related subjects privacy choices/manage cookies unrestricted educational grant full article pdf european economic area carrer del dr conditions privacy policy molecular biology check access instant access accepting optional cookies rb pathways main content log journal finder publish article clinical lópez-knowles fgfr3 p53 privacy policy article log personal data chromosome 9 alterations tp53 alterations books a author correspondence clinical application article cite optional cookies article luis manage preferences spain nuno data protection essential cookies cookies skip subscription content similar content spain francisco molecular prognostication molecular era institution subscribe journal publish usage analysis social media varying standards january 2007 volume 9

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         headline:Molecular biology of bladder cancer
         description: Bladder cancer is a major cause of health expenses and it presents formidable clinical challenges. Two types of tumors have been identified, papillary and non-papillary. The former are mainly characterized by FGFR3 and chromosome 9 alterations and a low frequency of Tp53 alterations. The latter are characterized by a high frequency of alterations in genes in the p53 and Rb pathways. Chromosome 9 alterations, specially in 9q, are crucial to bladder cancer development and occur in both types of tumors. Progression of some superficial tumors (mainly TaG3 and T1G3) to high-grade, invasive, carcinomas provides evidence of some overlap between the two pathways. Distinct gene expression profiles have been identified in superficial and invasive tumors. The stage is now ready for the clinical application of this knowledge.
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      headline:Molecular biology of bladder cancer
      description: Bladder cancer is a major cause of health expenses and it presents formidable clinical challenges. Two types of tumors have been identified, papillary and non-papillary. The former are mainly characterized by FGFR3 and chromosome 9 alterations and a low frequency of Tp53 alterations. The latter are characterized by a high frequency of alterations in genes in the p53 and Rb pathways. Chromosome 9 alterations, specially in 9q, are crucial to bladder cancer development and occur in both types of tumors. Progression of some superficial tumors (mainly TaG3 and T1G3) to high-grade, invasive, carcinomas provides evidence of some overlap between the two pathways. Distinct gene expression profiles have been identified in superficial and invasive tumors. The stage is now ready for the clinical application of this knowledge.
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