We are analyzing https://link.springer.com/article/10.1007/s12079-012-0179-x.

Title:
Post-transcriptional regulation in cancer progression | Journal of Cell Communication and Signaling
Description:
The microenvironment acts as a conduit for cellular communication, delivering signals that direct development and sustain tissue homeostasis. In pathologies such as cancer, this integral function of the microenvironment is hijacked to support tumor growth and progression. Cells sense the microenvironment via signal transduction pathways culminating in altered gene expression. In addition to induced transcriptional changes, the microenvironment exerts its effect on the cell through regulation of post-transcriptional processes including alternative splicing and translational control. Here we describe how alternative splicing and protein translation are controlled by microenvironmental parameters such as oxygen availability. We also emphasize how these pathways can be utilized to support processes that are hallmarks of cancer such as angiogenesis, proliferation, and cell migration. We stress that cancer cells respond to their microenvironment through an integrated regulation of gene expression at multiple levels that collectively contribute to disease progression.
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Keywords {🔍}

google, scholar, pubmed, article, cas, cancer, cell, splicing, factor, growth, translation, alternative, biol, regulation, expression, res, human, mol, cells, gene, endothelial, melanoma, initiation, vascular, wang, microenvironment, tumor, breast, protein, hypoxia, mrna, progression, vegf, angiogenesis, mtor, nature, internal, entry, chem, eife, sonenberg, carcinoma, ribosome, research, signaling, control, postovit, cellular, translational, stress,

Topics {✒️}

mouse hypoxia-inducible factor-1alpha hypoxia-inducible factor-1alpha mrna month download article/chapter snail1-induced epithelial-mesenchymal transition epithelial cell-type-specific regulators proto-oncogene/translation factor eif4e transcript-selective translational induction platelet-derived growth factor phosphoinositide 3-kinase/akt pathway splicing factor tra2-beta1 alternative pre-mrna splicing internal ribosome entry tgf-beta-mediated phosphorylation mouse mammary tumors sf2/asf proto-oncogene human glioma-initiating cells endoplasmic reticulum stress growth factor-inducible multi-tumor tissue microarray pi3k/akt/mtor pathway serex-defined antigen overexpressed pritchard-jones ro stringent tissue-specific regulation gittenberger-de groot ac post-transcriptional regulation erk-regulated differential expression single-cell rna sequencing regulated tumor-promoting switch findlay & lynne-marie postovit hypoxia-inducible factor 1 fibroblast growth factors rna-binding protein sam68 vascular permeability factor eif-4e activity protein-coupled receptor human mena protein full article pdf abrogates cell-cell adhesion e-cadherin transcriptional repression sam68 regulates emt epithelial-mesenchymal transition m2 splice isoform translation complex eif4f phosphorylated 4e-bp1 regulates alternative splicing authors confirm independence support tumor growth primary mammary tumors pi3k/akt pathway epithelial-mesenchymal transitions

Questions {❓}

Harper SJ, Bates DO (2008) VEGF-A splicing: the key to anti-angiogenic therapeutics?

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