We are analyzing https://link.springer.com/article/10.1007/s12038-017-9691-8.

Title:
Differential reduction of reactive oxygen species by human tissue-specific mesenchymal stem cells from different donors under oxidative stress | Journal of Biosciences
Description:
Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of various diseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinely used in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions. Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not been reported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reduction abilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocytes were treated with Antimycin A (AMA) to induce oxidative stress and tissue specific MSCs were co-cultured to study the reduction in ROS levels. We found that both donor’s age and source of tissue affected the ability of MSCs to reduce increased ROS levels in damaged cells. In addition, the abilities of same MSCs differed in LX-2 and cardiomyocytes in terms of magnitude of reduction of ROS, suggesting that the type of recipient cells should be kept in consideration when using MSCs in regenerative medicine for treatment purposes.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, cells, article, stem, google, scholar, mesenchymal, cas, cell, central, human, bone, marrow, oxidative, tissue, stress, mscs, oxygen, analysis, reactive, species, mohanty, adipose, regenerative, ros, injury, privacy, cookies, journal, reduction, airan, umbilical, cord, sci, stromal, int, kim, content, information, publish, research, search, tissuespecific, donors, paliwal, kakkar, medicine, access, therapy, comparative,

Topics {✒️}

bone-marrow-derived stromal cells month download article/chapter oxidative stress-induced toxicity reactive oxygen species mesenchymal stem cells mesenchymal stromal cells stem cells dev tissue-specific mscs tissue specific mscs article paliwal stem cell res stem cells int hepatic stellate cells acute lung injury cancer cell metabolism full article pdf induce oxidative stress umbilical cord blood author information authors privacy choices/manage cookies endothelial progenitor cells acute tubular injury ros-induced apoptosis regenerative medicine applied electronic supplementary material ameliorate oxidative damage support hematopoietic reconstitution cell therapy check access pulmonary alveoli protects instant access sujata mohanty 2014 differential efficacy article journal european economic area shown promising results mitigate cellular damage author correspondence oxidative stress 2003 oxidative stress umbilical cord xeno-free conditions 2012 mitochondrial transfer conditions privacy policy article log adipose tissue accepting optional cookies liver fibrosis bone marrow bone marrow

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Differential reduction of reactive oxygen species by human tissue-specific mesenchymal stem cells from different donors under oxidative stress
         description:Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of various diseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinely used in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions. Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not been reported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reduction abilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocytes were treated with Antimycin A (AMA) to induce oxidative stress and tissue specific MSCs were co-cultured to study the reduction in ROS levels. We found that both donor’s age and source of tissue affected the ability of MSCs to reduce increased ROS levels in damaged cells. In addition, the abilities of same MSCs differed in LX-2 and cardiomyocytes in terms of magnitude of reduction of ROS, suggesting that the type of recipient cells should be kept in consideration when using MSCs in regenerative medicine for treatment purposes.
         datePublished:2017-06-24T00:00:00Z
         dateModified:2017-06-24T00:00:00Z
         pageStart:373
         pageEnd:382
         sameAs:https://doi.org/10.1007/s12038-017-9691-8
         keywords:
            Oxidative stress
            reactive oxygen species
            tissue-specific mesenchymal stem cells
            Life Sciences
            general
            Biomedicine
            Zoology
            Plant Sciences
            Microbiology
            Cell Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig6_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig7_HTML.gif
         isPartOf:
            name:Journal of Biosciences
            issn:
               0973-7138
               0250-5991
            volumeNumber:42
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer India
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Swati Paliwal
               affiliation:
                     name:All India Institute of Medical Sciences
                     address:
                        name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anupama Kakkar
               affiliation:
                     name:All India Institute of Medical Sciences
                     address:
                        name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rinkey Sharma
               affiliation:
                     name:All India Institute of Medical Sciences
                     address:
                        name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Balram Airan
               affiliation:
                     name:All India Institute of Medical Sciences
                     address:
                        name:Department of Cardio Thoracic Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sujata Mohanty
               affiliation:
                     name:All India Institute of Medical Sciences
                     address:
                        name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Differential reduction of reactive oxygen species by human tissue-specific mesenchymal stem cells from different donors under oxidative stress
      description:Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of various diseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinely used in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions. Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not been reported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reduction abilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocytes were treated with Antimycin A (AMA) to induce oxidative stress and tissue specific MSCs were co-cultured to study the reduction in ROS levels. We found that both donor’s age and source of tissue affected the ability of MSCs to reduce increased ROS levels in damaged cells. In addition, the abilities of same MSCs differed in LX-2 and cardiomyocytes in terms of magnitude of reduction of ROS, suggesting that the type of recipient cells should be kept in consideration when using MSCs in regenerative medicine for treatment purposes.
      datePublished:2017-06-24T00:00:00Z
      dateModified:2017-06-24T00:00:00Z
      pageStart:373
      pageEnd:382
      sameAs:https://doi.org/10.1007/s12038-017-9691-8
      keywords:
         Oxidative stress
         reactive oxygen species
         tissue-specific mesenchymal stem cells
         Life Sciences
         general
         Biomedicine
         Zoology
         Plant Sciences
         Microbiology
         Cell Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig6_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-017-9691-8/MediaObjects/12038_2017_9691_Fig7_HTML.gif
      isPartOf:
         name:Journal of Biosciences
         issn:
            0973-7138
            0250-5991
         volumeNumber:42
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer India
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Swati Paliwal
            affiliation:
                  name:All India Institute of Medical Sciences
                  address:
                     name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anupama Kakkar
            affiliation:
                  name:All India Institute of Medical Sciences
                  address:
                     name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rinkey Sharma
            affiliation:
                  name:All India Institute of Medical Sciences
                  address:
                     name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Balram Airan
            affiliation:
                  name:All India Institute of Medical Sciences
                  address:
                     name:Department of Cardio Thoracic Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sujata Mohanty
            affiliation:
                  name:All India Institute of Medical Sciences
                  address:
                     name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Biosciences
      issn:
         0973-7138
         0250-5991
      volumeNumber:42
Organization:
      name:Springer India
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:All India Institute of Medical Sciences
      address:
         name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
         type:PostalAddress
      name:All India Institute of Medical Sciences
      address:
         name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
         type:PostalAddress
      name:All India Institute of Medical Sciences
      address:
         name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
         type:PostalAddress
      name:All India Institute of Medical Sciences
      address:
         name:Department of Cardio Thoracic Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India
         type:PostalAddress
      name:All India Institute of Medical Sciences
      address:
         name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Swati Paliwal
      affiliation:
            name:All India Institute of Medical Sciences
            address:
               name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
               type:PostalAddress
            type:Organization
      name:Anupama Kakkar
      affiliation:
            name:All India Institute of Medical Sciences
            address:
               name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
               type:PostalAddress
            type:Organization
      name:Rinkey Sharma
      affiliation:
            name:All India Institute of Medical Sciences
            address:
               name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
               type:PostalAddress
            type:Organization
      name:Balram Airan
      affiliation:
            name:All India Institute of Medical Sciences
            address:
               name:Department of Cardio Thoracic Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India
               type:PostalAddress
            type:Organization
      name:Sujata Mohanty
      affiliation:
            name:All India Institute of Medical Sciences
            address:
               name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
      name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
      name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
      name:Department of Cardio Thoracic Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India
      name:Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(139)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.48s.

LINK . SPRINGER . COM {}