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  2. Matching Content Categories
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  4. Monthly Traffic Estimate
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We are analyzing https://link.springer.com/article/10.1007/s12035-014-9080-3.

Title:
Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival | Molecular Neurobiology
Description:
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) plays an important role in influence of pre-messenger RNA (pre-mRNA) processing and mRNA metabolism and transportation in cells. Increasing evidence indicates that hnRNP A2/B1 played an important role in development and progression of various human cancers. Forty cases of normal and human glioma tissue samples were analyzed using immunohistochemistry to reveal the expression of hnRNP A2/B1 protein in the samples. Then, knockdown of hnRNP A2/B1 expression induced by RNA interference (RNAi) method was used to analyze the role of hnRNP A2/B1 in glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for temozolomide (TMZ). The data showed that hnRNP A2/B1 protein was overexpressed in glioma tissue specimens and associated with advanced glioma grades. Knockdown of hnRNP A2/B1 could reduce glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for TMZ capacity, but induced tumor cells to apoptosis and reactive oxygen species (ROS) generation in glioma U251 and SHG44 cells. Molecularly, hnRNP A2/B1 knockdown reduced expression of phospho-STAT3 and MMP-2. Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression and knockdown of hnRNP A2/B1 expression as a novel strategy in future control of glioblastoma in clinic.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Science
  • Telecommunications

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {šŸ’ø}

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Keywords {šŸ”}

pubmed, article, google, scholar, cas, cell, hnrnp, cancer, glioma, invasion, cells, expression, glioblastoma, central, nuclear, human, chongqing, res, proteins, knockdown, growth, wang, heterogeneous, role, tumor, malignant, protein, access, clin, mol, biol, oncogene, china, medical, privacy, cookies, content, molecular, gliomas, oncol, dreyfuss, stat, department, neurosurgery, peoples, republic, function, data, publish, research,

Topics {āœ’ļø}

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Schema {šŸ—ŗļø}

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         headline:Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival
         description:Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) plays an important role in influence of pre-messenger RNA (pre-mRNA) processing and mRNA metabolism and transportation in cells. Increasing evidence indicates that hnRNP A2/B1 played an important role in development and progression of various human cancers. Forty cases of normal and human glioma tissue samples were analyzed using immunohistochemistry to reveal the expression of hnRNP A2/B1 protein in the samples. Then, knockdown of hnRNP A2/B1 expression induced by RNA interference (RNAi) method was used to analyze the role of hnRNP A2/B1 in glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for temozolomide (TMZ). The data showed that hnRNP A2/B1 protein was overexpressed in glioma tissue specimens and associated with advanced glioma grades. Knockdown of hnRNP A2/B1 could reduce glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for TMZ capacity, but induced tumor cells to apoptosis and reactive oxygen species (ROS) generation in glioma U251 and SHG44 cells. Molecularly, hnRNP A2/B1 knockdown reduced expression of phospho-STAT3 and MMP-2. Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression and knockdown of hnRNP A2/B1 expression as a novel strategy in future control of glioblastoma in clinic.
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                     address:
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      headline:Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival
      description:Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) plays an important role in influence of pre-messenger RNA (pre-mRNA) processing and mRNA metabolism and transportation in cells. Increasing evidence indicates that hnRNP A2/B1 played an important role in development and progression of various human cancers. Forty cases of normal and human glioma tissue samples were analyzed using immunohistochemistry to reveal the expression of hnRNP A2/B1 protein in the samples. Then, knockdown of hnRNP A2/B1 expression induced by RNA interference (RNAi) method was used to analyze the role of hnRNP A2/B1 in glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for temozolomide (TMZ). The data showed that hnRNP A2/B1 protein was overexpressed in glioma tissue specimens and associated with advanced glioma grades. Knockdown of hnRNP A2/B1 could reduce glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for TMZ capacity, but induced tumor cells to apoptosis and reactive oxygen species (ROS) generation in glioma U251 and SHG44 cells. Molecularly, hnRNP A2/B1 knockdown reduced expression of phospho-STAT3 and MMP-2. Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression and knockdown of hnRNP A2/B1 expression as a novel strategy in future control of glioblastoma in clinic.
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         Neurobiology
         Cell Biology
         Neurology
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                  name:Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders
                  address:
                     name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
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                     name:Department of Neurosurgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
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                     type:PostalAddress
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            name:Zongyi Xie
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                  name:Chongqing Medical University
                  address:
                     name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
                     type:PostalAddress
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            name:Zhongye Xu
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                  name:Chongqing Medical University
                  address:
                     name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
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                     type:PostalAddress
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                  address:
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                  address:
                     name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
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                  address:
                     name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
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               name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
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      name:Hongxin Zhao
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            address:
               name:Department of Neurosurgery, First Affiliated Hospital, Zunyi Medical College, Zunyi, People’s Republic of China
               type:PostalAddress
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      name:Zongyi Xie
      affiliation:
            name:Chongqing Medical University
            address:
               name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
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      name:Zhongye Xu
      affiliation:
            name:Chongqing Medical University
            address:
               name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Qingtao Zhang
      affiliation:
            name:Chongqing Emergency Medical Center
            address:
               name:Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Ping Liang
      affiliation:
            name:Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders
            address:
               name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Xuan Zhai
      affiliation:
            name:Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders
            address:
               name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yuan Cheng
      affiliation:
            name:Chongqing Medical University
            address:
               name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, First Affiliated Hospital, Zunyi Medical College, Zunyi, People’s Republic of China
      name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, People’s Republic of China
      name:Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China
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