We are analyzing https://link.springer.com/article/10.1007/s12032-015-0655-2.

Title:
PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma | Medical Oncology
Description:
The incidence of kidney cancer has been increasing globally during the past two decades. Renal cell carcinoma (RCC) is the most aggressive subtype of kidney cancer, which usually deteriorates with epithelial–mesenchymal transition (EMT) that facilitates the migration and invasion of cancer cells. Till now, the underlying mechanism remains unclear. In this study, we demonstrated that programmed death ligand 1 (PD-L1/B7-H1/CD274) could induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Furthermore, we found that PD-L1 is up-regulated in human RCC metastases. These results, taken together, provide evidence for a novel mechanism of PD-L1 in RCC progression, suggesting that there is a close relationship between EMT and immune escape signaling pathways in RCC.
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Keywords {🔍}

article, pubmed, cancer, google, scholar, cas, cell, renal, carcinoma, pdl, wang, transition, cells, privacy, cookies, content, research, rcc, programmed, death, ligand, central, tumor, information, publish, search, srebpc, epithelialmesenchymal, mechanism, access, med, res, tcell, immunol, author, data, log, journal, yiwei, hang, zhao, jianming, guo, incidence, kidney, emt, immune, patients, role, implications,

Topics {✒️}

pd-l1 induces epithelial epithelial–mesenchymal transition inducer xiaoyi hu & jianming guo pd-l1/b7-h1/cd274 renal cell carcinoma t-cell lymphoproliferative disorders month download article/chapter epithelial–mesenchymal transition triple-negative breast cancer pd-l1/pd-1 pathway activating srebp-1c tumor b7-h1 t-cell exhaustion full article pdf scientific research projects t-cell immunity privacy choices/manage cookies b7-cd28 family cancer immunol immunother b7-h1 mesenchymal transition srebp-1c mesenchymal transition related subjects ann cancer res pd-l1/cd274 programmed death 1 pathological lipid homeostasis regional geographic variations annu rev immunol long-term follow trends endocrinol metab human rcc metastases epithelial stem suppresses host immunity conditions privacy policy jianming guo european economic area population-based analysis nat rev immunol article wang accepting optional cookies ethical standards laid ann transl med breast cancer article number 212 check access instant access article log ductal carcinoma

Questions {❓}

Do programmed death 1 (PD-1) and its ligand (PD-L1) play a role in patients with non-clear cell renal cell carcinoma?

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