We are analyzing https://link.springer.com/article/10.1007/s12032-014-0372-2.

Title:
High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival | Medical Oncology
Description:
RAB27A is a member of Rab family GTPases involved in cellular vesicle trafficking, and TP53 has recently been implicated in regulating the exosome secretion pathway. Because exosome secretion plays an important role in modulating tumor microenvironment and invasive growth, we hypothesized that RAB27A and TP53 expression might be associated with aggressive behavior in pancreatic ductal adenocarcinoma (PDAC), one of the most deadly human malignancies. We determined protein expression of RAB27A and TP53 in 265 pancreatic tissues (186 carcinomas and 79 normal or benign tissues) by immunohistochemistry analysis on tissue microarray and found their expression was correlated with patients’ clinical parameters and overall survival. We found that RAB27A and TP53 protein expression was significantly higher in cancerous tissues compared to normal and benign tissues. High RAB27A protein expression (RAB27A+) was significantly associated with tumor stage and vascular invasion. No correlation between RAB27A and TP53 expression was observed. Patients with high RAB27A expression and high TP53 expression had a poor overall survival. Our data indicate that RAB27A expression is an independent prognostic marker for PDAC, and RAB27A-regulated exosome secretion pathway may represent a novel therapeutic target in pancreatic cancer .
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Keywords {🔍}

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Topics {✒️}

month download article/chapter tumour-promoting stromal myofibroblasts igf-1/akt/mtor pathways pancreatic ductal adenocarcinoma pancreatic cancer research tsap6/steap3-null mice rab27a supports exosome-dependent tumor suppressor gene malignant gastrointestinal tissues emt-related proteins bladder cancer colon cancer resectable pancreatic cancer full article pdf p53 proteins expression breast cancer cells human cancers strongly predicts survival privacy choices/manage cookies secretory granule exocytosis translational medicine research global cancer statistics national cancer database cancer immune escape growth factor-ii mol cancer res pancreatic cancer determined protein expression pancreatic adenocarcinoma high rab27a expression high tp53 expression tp53 protein expression exosome secretion pathway immunohistochemically detected expression deadly human malignancies prognostic factors related human glioma cell article wang european economic area related subjects reactive oxygen species hepatobiliary pancreat sci docking machinery composed biochem soc trans jianfei huang cell death differ tumour biol steroid receptor expression conditions privacy policy modulating tumor microenvironment

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         description:RAB27A is a member of Rab family GTPases involved in cellular vesicle trafficking, and TP53 has recently been implicated in regulating the exosome secretion pathway. Because exosome secretion plays an important role in modulating tumor microenvironment and invasive growth, we hypothesized that RAB27A and TP53 expression might be associated with aggressive behavior in pancreatic ductal adenocarcinoma (PDAC), one of the most deadly human malignancies. We determined protein expression of RAB27A and TP53 in 265 pancreatic tissues (186 carcinomas and 79 normal or benign tissues) by immunohistochemistry analysis on tissue microarray and found their expression was correlated with patients’ clinical parameters and overall survival. We found that RAB27A and TP53 protein expression was significantly higher in cancerous tissues compared to normal and benign tissues. High RAB27A protein expression (RAB27A+) was significantly associated with tumor stage and vascular invasion. No correlation between RAB27A and TP53 expression was observed. Patients with high RAB27A expression and high TP53 expression had a poor overall survival. Our data indicate that RAB27A expression is an independent prognostic marker for PDAC, and RAB27A-regulated exosome secretion pathway may represent a novel therapeutic target in pancreatic cancer .
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