We are analyzing https://link.springer.com/article/10.1007/s12032-014-0082-9.

Title:
The effect of immune microenvironment on the progression and prognosis of colorectal cancer | Medical Oncology
Description:
Cancer cells may escape from host immune responses through active suppression of the immune response, but the detailed mechanisms in colorectal cancer remain to be elucidated. In this study, 108 colorectal tumor samples and their peritumoral tissues were collected for immunohistochemistry of infiltrating lymphocytes. Th1 and Tregs cells were determined by the positive expression of T-bet and FOXP3 proteins, respectively. The Tr1 cells were identified by CD49b and LAG-3 protein expression. IL-17-positive cells were identified by IL-17 expression. Results showed that the percentage of T-bet-positive cells was significantly decreased, while the percentages of IL-17-, FOXP3-, CD49b-, and LAG-3-positive cells were significantly increased in tumor tissues compared to that in peritumoral tissues. The ratio of IL-17-, FOXP3-, CD49b-, and LAG3-positive cells to T-bet-positive cells was significantly higher in tumor tissues than in peritumoral tissues. The percentage of infiltrating IL-17-positive cells in tumor tissues was negatively associated with lymph metastasis, invasion, and TNM stage. The percentage of CD49b- and LAG-3-positive cells was positively associated with differentiation, lymph metastasis, invasion, TNM, and Duke stage of colorectal cancer. The percentage of positive Th17 and Tr1 cells is a marker for poor prognosis in patients with CRC. In conclusion, decreased composition of regulative Th1 cells and increased composition of FOXP+ Tregs-, CD49b+/LAG-3+ Tr1-, and IL-17-positive cells in tumor tissues may be associated with the progression of colorectal cancer. The high percentage of IL-17- and Tr1-positive cells in tumor tissues is a predictive marker for poor prognosis of colorectal cancer.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, pubmed, cancer, cells, google, scholar, colorectal, cas, regulatory, foxp, immune, tumor, central, chen, tissues, cell, human, progression, prognosis, patients, prognostic, clin, privacy, cookies, content, microenvironment, expression, cdb, percentage, med, immunol, publish, search, infiltrating, high, access, factor, res, van, nat, data, information, change, log, journal, research, zihua, response, study, peritumoral,

Topics {✒️}

tumour-infiltrating t-cell subsets month download article/chapter t-cell tumor infiltration mmr-proficient colorectal carcinomas t-bet-positive cells cd8 + cd25 + foxp3 + suppressive central south university stimulated human cd4 + cd25 poor-prognosis colon cancer high rorγt/cd3 ratio de villena mecm full article pdf infiltrating il-17-positive cells de rooij lp de boer oj tumor-infiltrating foxp3 + regulatory privacy choices/manage cookies de jong jh advanced colorectal cancer interleukin-17 promotes angiogenesis zihua chen regulatory cell access article chen strong prognostic factor colorectal cancer patients interleukin-17ra expression von knebel dm colorectal cancer remain colorectal cancer tissue human colorectal cancers lag-3 identifies human lag-3-positive cells lag3-positive cells european economic area related subjects molecularly distinct subtype serrated precursor lesions reina zoilo jj anti-angiogenic therapy magnani cf stimulating vegf production tumor-infiltrating foxp3 + human tr1 cells blimp-1+ effector regulatory conditions privacy policy tr1-positive cells bmc cancer favorable prognostic factor van der heijden van noesel cj

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The effect of immune microenvironment on the progression and prognosis of colorectal cancer
         description:Cancer cells may escape from host immune responses through active suppression of the immune response, but the detailed mechanisms in colorectal cancer remain to be elucidated. In this study, 108 colorectal tumor samples and their peritumoral tissues were collected for immunohistochemistry of infiltrating lymphocytes. Th1 and Tregs cells were determined by the positive expression of T-bet and FOXP3 proteins, respectively. The Tr1 cells were identified by CD49b and LAG-3 protein expression. IL-17-positive cells were identified by IL-17 expression. Results showed that the percentage of T-bet-positive cells was significantly decreased, while the percentages of IL-17-, FOXP3-, CD49b-, and LAG-3-positive cells were significantly increased in tumor tissues compared to that in peritumoral tissues. The ratio of IL-17-, FOXP3-, CD49b-, and LAG3-positive cells to T-bet-positive cells was significantly higher in tumor tissues than in peritumoral tissues. The percentage of infiltrating IL-17-positive cells in tumor tissues was negatively associated with lymph metastasis, invasion, and TNM stage. The percentage of CD49b- and LAG-3-positive cells was positively associated with differentiation, lymph metastasis, invasion, TNM, and Duke stage of colorectal cancer. The percentage of positive Th17 and Tr1 cells is a marker for poor prognosis in patients with CRC. In conclusion, decreased composition of regulative Th1 cells and increased composition of FOXP+ Tregs-, CD49b+/LAG-3+ Tr1-, and IL-17-positive cells in tumor tissues may be associated with the progression of colorectal cancer. The high percentage of IL-17- and Tr1-positive cells in tumor tissues is a predictive marker for poor prognosis of colorectal cancer.
         datePublished:2014-07-18T00:00:00Z
         dateModified:2014-07-18T00:00:00Z
         pageStart:1
         pageEnd:8
         sameAs:https://doi.org/10.1007/s12032-014-0082-9
         keywords:
            Colorectal cancer
            Tumor-infiltrating T cells
            Regulatory T cell
            T-helper 1 cell
            T-helper 17 cell
            Type 1 T regulatory cell
            Oncology
            Hematology
            Pathology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-014-0082-9/MediaObjects/12032_2014_82_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-014-0082-9/MediaObjects/12032_2014_82_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-014-0082-9/MediaObjects/12032_2014_82_Fig3_HTML.gif
         isPartOf:
            name:Medical Oncology
            issn:
               1559-131X
               1357-0560
            volumeNumber:31
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jinxiang Chen
               affiliation:
                     name:Central South University
                     address:
                        name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zihua Chen
               affiliation:
                     name:Central South University
                     address:
                        name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The effect of immune microenvironment on the progression and prognosis of colorectal cancer
      description:Cancer cells may escape from host immune responses through active suppression of the immune response, but the detailed mechanisms in colorectal cancer remain to be elucidated. In this study, 108 colorectal tumor samples and their peritumoral tissues were collected for immunohistochemistry of infiltrating lymphocytes. Th1 and Tregs cells were determined by the positive expression of T-bet and FOXP3 proteins, respectively. The Tr1 cells were identified by CD49b and LAG-3 protein expression. IL-17-positive cells were identified by IL-17 expression. Results showed that the percentage of T-bet-positive cells was significantly decreased, while the percentages of IL-17-, FOXP3-, CD49b-, and LAG-3-positive cells were significantly increased in tumor tissues compared to that in peritumoral tissues. The ratio of IL-17-, FOXP3-, CD49b-, and LAG3-positive cells to T-bet-positive cells was significantly higher in tumor tissues than in peritumoral tissues. The percentage of infiltrating IL-17-positive cells in tumor tissues was negatively associated with lymph metastasis, invasion, and TNM stage. The percentage of CD49b- and LAG-3-positive cells was positively associated with differentiation, lymph metastasis, invasion, TNM, and Duke stage of colorectal cancer. The percentage of positive Th17 and Tr1 cells is a marker for poor prognosis in patients with CRC. In conclusion, decreased composition of regulative Th1 cells and increased composition of FOXP+ Tregs-, CD49b+/LAG-3+ Tr1-, and IL-17-positive cells in tumor tissues may be associated with the progression of colorectal cancer. The high percentage of IL-17- and Tr1-positive cells in tumor tissues is a predictive marker for poor prognosis of colorectal cancer.
      datePublished:2014-07-18T00:00:00Z
      dateModified:2014-07-18T00:00:00Z
      pageStart:1
      pageEnd:8
      sameAs:https://doi.org/10.1007/s12032-014-0082-9
      keywords:
         Colorectal cancer
         Tumor-infiltrating T cells
         Regulatory T cell
         T-helper 1 cell
         T-helper 17 cell
         Type 1 T regulatory cell
         Oncology
         Hematology
         Pathology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-014-0082-9/MediaObjects/12032_2014_82_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-014-0082-9/MediaObjects/12032_2014_82_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-014-0082-9/MediaObjects/12032_2014_82_Fig3_HTML.gif
      isPartOf:
         name:Medical Oncology
         issn:
            1559-131X
            1357-0560
         volumeNumber:31
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jinxiang Chen
            affiliation:
                  name:Central South University
                  address:
                     name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zihua Chen
            affiliation:
                  name:Central South University
                  address:
                     name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Medical Oncology
      issn:
         1559-131X
         1357-0560
      volumeNumber:31
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Central South University
      address:
         name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
      name:Central South University
      address:
         name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jinxiang Chen
      affiliation:
            name:Central South University
            address:
               name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Zihua Chen
      affiliation:
            name:Central South University
            address:
               name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
      name:Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(118)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.63s.

LINK . SPRINGER . COM {}