We are analyzing https://link.springer.com/article/10.1007/s12032-012-0393-7.

Title:
BsmI but not FokI polymorphism of VDR gene is contributed in breast cancer | Medical Oncology
Description:
There is growing evidence of a malignancy-protective role for vitamin D in breast cancer. The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene. Several SNPs on VDR gene has attracted research interest, although the magnitude of the impact of VDR allelic variations on breast cancer has been controversial. In the present study, we focused on the distribution of VDR FokI and BsmI polymorphisms in Iranian breast cancer patients. A case–control study was conducted on 296 samples including 140 breast cancer patients and 156 age matched control women. Restriction fragment length polymorphism (RFLP) analysis was performed for BsmI and FokI genotyping. Randomly selected PCR products were subjected to sequencing to verify the RFLP results. A significantly increased risk of breast cancer was observed with BsmI bb or even Bb genotype (OR 2.39, CI 1.17–4.85 and OR 2.28, CI 1.16–4.47, respectively). Nevertheless, statistically significant association between FokI genotypes and breast cancer risk was not observed. This study lends support for an increased risk of breast cancer associated with the VDR BsmI polymorphism.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Non-Profit & Charity

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

cancer, article, vitamin, breast, google, scholar, pubmed, cas, receptor, gene, polymorphism, risk, polymorphisms, vdr, res, research, bsmi, colston, iran, foki, study, human, patients, association, mol, bone, tehran, privacy, cookies, content, medical, iranian, access, cell, epidemiol, population, information, publish, search, shahbazi, role, casecontrol, women, genotype, genetics, clin, endocrinol, mansi, postmenopausal, biomarkers,

Topics {✒️}

month download article/chapter nested case-control study bueno-de-mesquita hb early-onset breast cancer trans-acting factor alleles postmenopausal mexican-american women full article pdf common allelic variation reza mahdian case–control study study lends support privacy choices/manage cookies functionally relevant polymorphisms longitudinal population study morrison na breast cancer patients brca1/2-mutation carrier hereditary defects related author information authors sporadic breast cancer postmenopausal breast cancer attracted research interest medical genetics department case-control studies breast cancer prognosis breast cancer res metastatic breast cancer mol cell biol ingles sa african-american women breast cancer risk article shahbazi human leukaemia cells sara alavi related subjects structural organization bone mineral density postmenopausal bone loss transcription factor iib receptor gene polymorphism endocr relat cancer genomics genetic predisposition french canadian population malignant breast tissue clin cancer res human chromosome 12q13-14 european economic area check access dna repair genes bone miner res

Questions {❓}

Targeted therapy in breast cancer: what’s new?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:BsmI but not FokI polymorphism of VDR gene is contributed in breast cancer
         description:There is growing evidence of a malignancy-protective role for vitamin D in breast cancer. The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene. Several SNPs on VDR gene has attracted research interest, although the magnitude of the impact of VDR allelic variations on breast cancer has been controversial. In the present study, we focused on the distribution of VDR FokI and BsmI polymorphisms in Iranian breast cancer patients. A case–control study was conducted on 296 samples including 140 breast cancer patients and 156 age matched control women. Restriction fragment length polymorphism (RFLP) analysis was performed for BsmI and FokI genotyping. Randomly selected PCR products were subjected to sequencing to verify the RFLP results. A significantly increased risk of breast cancer was observed with BsmI bb or even Bb genotype (OR 2.39, CI 1.17–4.85 and OR 2.28, CI 1.16–4.47, respectively). Nevertheless, statistically significant association between FokI genotypes and breast cancer risk was not observed. This study lends support for an increased risk of breast cancer associated with the VDR BsmI polymorphism.
         datePublished:2013-01-01T00:00:00Z
         dateModified:2013-01-01T00:00:00Z
         pageStart:1
         pageEnd:6
         sameAs:https://doi.org/10.1007/s12032-012-0393-7
         keywords:
            Vitamin D receptor
            Breast cancer
            Single nucleotide polymorphism
            RFLP
            Oncology
            Hematology
            Pathology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-012-0393-7/MediaObjects/12032_2012_393_Fig1_HTML.gif
         isPartOf:
            name:Medical Oncology
            issn:
               1559-131X
               1357-0560
            volumeNumber:30
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Shirin Shahbazi
               affiliation:
                     name:Tarbiat Modares University
                     address:
                        name:Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sara Alavi
               affiliation:
                     name:Pasteur Institute of Iran
                     address:
                        name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Keivan Majidzadeh-A
               affiliation:
                     name:Academic Center for Education, Culture and Research (ACECR)
                     address:
                        name:Breast Cancer Research Center, Iranian Center for Breast Cancer (ICBC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Massoud GhaffarPour
               affiliation:
                     name:National Institute of Genetic Engineering and Biotechnology
                     address:
                        name:Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
                        type:PostalAddress
                     type:Organization
                     name:Iranian Research Organization for Science and Technology (IROST)
                     address:
                        name:Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Azam Soleimani
               affiliation:
                     name:Islamic Azad University
                     address:
                        name:Science and Research Branch, Islamic Azad University, Tehran, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Reza Mahdian
               affiliation:
                     name:Pasteur Institute of Iran
                     address:
                        name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:BsmI but not FokI polymorphism of VDR gene is contributed in breast cancer
      description:There is growing evidence of a malignancy-protective role for vitamin D in breast cancer. The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene. Several SNPs on VDR gene has attracted research interest, although the magnitude of the impact of VDR allelic variations on breast cancer has been controversial. In the present study, we focused on the distribution of VDR FokI and BsmI polymorphisms in Iranian breast cancer patients. A case–control study was conducted on 296 samples including 140 breast cancer patients and 156 age matched control women. Restriction fragment length polymorphism (RFLP) analysis was performed for BsmI and FokI genotyping. Randomly selected PCR products were subjected to sequencing to verify the RFLP results. A significantly increased risk of breast cancer was observed with BsmI bb or even Bb genotype (OR 2.39, CI 1.17–4.85 and OR 2.28, CI 1.16–4.47, respectively). Nevertheless, statistically significant association between FokI genotypes and breast cancer risk was not observed. This study lends support for an increased risk of breast cancer associated with the VDR BsmI polymorphism.
      datePublished:2013-01-01T00:00:00Z
      dateModified:2013-01-01T00:00:00Z
      pageStart:1
      pageEnd:6
      sameAs:https://doi.org/10.1007/s12032-012-0393-7
      keywords:
         Vitamin D receptor
         Breast cancer
         Single nucleotide polymorphism
         RFLP
         Oncology
         Hematology
         Pathology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-012-0393-7/MediaObjects/12032_2012_393_Fig1_HTML.gif
      isPartOf:
         name:Medical Oncology
         issn:
            1559-131X
            1357-0560
         volumeNumber:30
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Shirin Shahbazi
            affiliation:
                  name:Tarbiat Modares University
                  address:
                     name:Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sara Alavi
            affiliation:
                  name:Pasteur Institute of Iran
                  address:
                     name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Keivan Majidzadeh-A
            affiliation:
                  name:Academic Center for Education, Culture and Research (ACECR)
                  address:
                     name:Breast Cancer Research Center, Iranian Center for Breast Cancer (ICBC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Massoud GhaffarPour
            affiliation:
                  name:National Institute of Genetic Engineering and Biotechnology
                  address:
                     name:Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
                     type:PostalAddress
                  type:Organization
                  name:Iranian Research Organization for Science and Technology (IROST)
                  address:
                     name:Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Azam Soleimani
            affiliation:
                  name:Islamic Azad University
                  address:
                     name:Science and Research Branch, Islamic Azad University, Tehran, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Reza Mahdian
            affiliation:
                  name:Pasteur Institute of Iran
                  address:
                     name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Medical Oncology
      issn:
         1559-131X
         1357-0560
      volumeNumber:30
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Tarbiat Modares University
      address:
         name:Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
         type:PostalAddress
      name:Pasteur Institute of Iran
      address:
         name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
         type:PostalAddress
      name:Academic Center for Education, Culture and Research (ACECR)
      address:
         name:Breast Cancer Research Center, Iranian Center for Breast Cancer (ICBC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran
         type:PostalAddress
      name:National Institute of Genetic Engineering and Biotechnology
      address:
         name:Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
         type:PostalAddress
      name:Iranian Research Organization for Science and Technology (IROST)
      address:
         name:Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
         type:PostalAddress
      name:Islamic Azad University
      address:
         name:Science and Research Branch, Islamic Azad University, Tehran, Iran
         type:PostalAddress
      name:Pasteur Institute of Iran
      address:
         name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Shirin Shahbazi
      affiliation:
            name:Tarbiat Modares University
            address:
               name:Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Sara Alavi
      affiliation:
            name:Pasteur Institute of Iran
            address:
               name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Keivan Majidzadeh-A
      affiliation:
            name:Academic Center for Education, Culture and Research (ACECR)
            address:
               name:Breast Cancer Research Center, Iranian Center for Breast Cancer (ICBC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Massoud GhaffarPour
      affiliation:
            name:National Institute of Genetic Engineering and Biotechnology
            address:
               name:Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
               type:PostalAddress
            type:Organization
            name:Iranian Research Organization for Science and Technology (IROST)
            address:
               name:Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Azam Soleimani
      affiliation:
            name:Islamic Azad University
            address:
               name:Science and Research Branch, Islamic Azad University, Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Reza Mahdian
      affiliation:
            name:Pasteur Institute of Iran
            address:
               name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
      name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
      name:Breast Cancer Research Center, Iranian Center for Breast Cancer (ICBC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran
      name:Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
      name:Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
      name:Science and Research Branch, Islamic Azad University, Tehran, Iran
      name:Biotechnology Research Center, Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(151)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.48s.

LINK . SPRINGER . COM {}