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Title:
Clinical efficacy of percutaneous cryoablation combined with allogenic NK cell immunotherapy for advanced non-small cell lung cancer | Immunologic Research
Description:
In this study, the safety and clinical efficacy of cryosurgery combined with allogenic NK cell immunotherapy for the treatment of advanced non-small cell lung cancer (NSCLC) were evaluated. From July 2016 to March 2017, we enrolled 60 patients who met the enrollment criteria and divided them into two groups: (1) the simple cryoablation group (n = 30) and (2) the cryoablation combined with allogenic NK cell group (n = 30). The changes in immune function, quality of life, and clinical response were evaluated. We found that allogenic NK cells combined with cryosurgical treatment for advanced NSCLC have a synergistic effect, which not only enhancing the immune function of patients, improving the quality of life, and significantly increasing the response rate (RR) and disease control rate (DCR) compared to cryoablation group. This study is the first clinical trial of allogenic NK cells combined with cryosurgery for the treatment of advanced NSCLC and preliminaily its safety and efficacy.
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Keywords {🔍}
pubmed, article, google, scholar, cancer, cell, cas, lung, killer, cells, patients, central, cryoablation, clinical, immunotherapy, treatment, immunol, natural, combined, advanced, nonsmall, efficacy, allogenic, cryosurgery, trial, access, research, percutaneous, niu, nonsmallcell, breast, fuda, privacy, cookies, content, search, liang, chen, haibo, immune, carcinoma, transplantation, adjuvant, human, hospital, china, publish, lin, wang, lizhi,
Topics {✒️}
hai-bo li nk cell-based immunotherapy small-cell lung cancers month download article/chapter small-cell lung cancer small-cell lung cancer kir/hla ligand incompatibility image-guided tumor ablation li-zhi niu killer cell ig killer cell immunoglobulin full article pdf ming-jie zhang small hepatocellular carcinoma postoperative adjuvant therapy anti-pd-1 antibody nk cell recognition posttransplant adoptive immunotherapy il-2-based immunotherapy related subjects enhanced antitumor effects induces specific killing acute effects advanced renal cancer tumor-specific cytotoxic privacy choices/manage cookies fuda cancer hospital cell mol immunol unresectable hepatocellular carcinoma metastatic nasopharyngeal carcinoma bone marrow transplantation china [y2016-zd-004] clinical research check access instant access metastatic breast cancer xiao-hua wang article lin randomized clinical trial dc-activated ciks hla-cw4 expression global cancer statistics nat rev cancer mol cancer ther ji-bing chen european economic area circulating lymphocyte subsets platinum regimen combined intraoperative thermoablation combined cardiovasc intervent radiol
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headline:Clinical efficacy of percutaneous cryoablation combined with allogenic NK cell immunotherapy for advanced non-small cell lung cancer
description:In this study, the safety and clinical efficacy of cryosurgery combined with allogenic NK cell immunotherapy for the treatment of advanced non-small cell lung cancer (NSCLC) were evaluated. From July 2016 to March 2017, we enrolled 60 patients who met the enrollment criteria and divided them into two groups: (1) the simple cryoablation group (n = 30) and (2) the cryoablation combined with allogenic NK cell group (n = 30). The changes in immune function, quality of life, and clinical response were evaluated. We found that allogenic NK cells combined with cryosurgical treatment for advanced NSCLC have a synergistic effect, which not only enhancing the immune function of patients, improving the quality of life, and significantly increasing the response rate (RR) and disease control rate (DCR) compared to cryoablation group. This study is the first clinical trial of allogenic NK cells combined with cryosurgery for the treatment of advanced NSCLC and preliminaily its safety and efficacy.
datePublished:2017-05-16T00:00:00Z
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Allogenic nature killer cell
Non-small cell lung cancer
Clinical efficacy
Clinical trial
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headline:Clinical efficacy of percutaneous cryoablation combined with allogenic NK cell immunotherapy for advanced non-small cell lung cancer
description:In this study, the safety and clinical efficacy of cryosurgery combined with allogenic NK cell immunotherapy for the treatment of advanced non-small cell lung cancer (NSCLC) were evaluated. From July 2016 to March 2017, we enrolled 60 patients who met the enrollment criteria and divided them into two groups: (1) the simple cryoablation group (n = 30) and (2) the cryoablation combined with allogenic NK cell group (n = 30). The changes in immune function, quality of life, and clinical response were evaluated. We found that allogenic NK cells combined with cryosurgical treatment for advanced NSCLC have a synergistic effect, which not only enhancing the immune function of patients, improving the quality of life, and significantly increasing the response rate (RR) and disease control rate (DCR) compared to cryoablation group. This study is the first clinical trial of allogenic NK cells combined with cryosurgery for the treatment of advanced NSCLC and preliminaily its safety and efficacy.
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Allogenic nature killer cell
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