We are analyzing https://link.springer.com/article/10.1007/s12026-014-8524-1.

Title:
Regulation of T cell responses by the receptor molecule Tim-3 | Immunologic Research
Description:
Tim-3 is a member of the T cell immunoglobulin and mucin domain (Tim) family of proteins, which are expressed by several cell types in the immune system, including CD4 and CD8 T cells activated under certain conditions. These molecules are generally thought to act as receptors for multiple ligands and thus to function by engaging intracellular signaling pathways in a ligand-dependent manner. In recent years, the function of the Tim-3 protein has been studied in some detail, particularly with respect to its role in the regulation of CD4 and CD8 T cell responses. Here, we review the structural features of Tim-3, known ligands for this molecule and the links established between Tim-3 and signal transduction pathways. In addition, we review the current literature regarding the role of Tim-3 in the regulation of effector responses by CD4 and CD8 T cells. Overall, findings published thus far strongly support the conclusion that Tim-3 functions to inhibit T cell responses, particularly under conditions involving chronic stimulation. Conversely, some reports have provided evidence that Tim-3 can stimulate T cells under conditions involving acute stimulation, suggesting that the role of Tim-3 may vary depending on context. Further study of Tim-3 is likely to advance our understanding of how CD4 and CD8 T cell responses are regulated and could uncover novel approaches for manipulating T cell function for therapeutic benefit.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, article, google, scholar, cas, tim, cell, central, immunol, cells, mucin, galectin, responses, infection, receptor, zhang, hepatitis, wang, immune, activation, tcell, plos, immunoglobulin, immunity, disease, regulation, regulates, expression, pathway, anderson, regulatory, lee, exhaustion, clin, function, domain, protein, role, effector, chronic, chen, nat, molecule, family, zhu, kuchroo, usa, timgalectin, receptors, signaling,

Topics {✒️}

cd11b + ly-6g + myeloid cells galectin-9-independent ligand-binding surface month download article/chapter inhibits ifn-gamma production t-cell homeostatic programs enhance t-cell migration restore anti-tumor immunity allergen-induced airway inflammation cell-mediated immune response signal transduction pathways effector t-cell apoptosis kupffer cell-derived galectin-9 blockade restores hepatocyte-directed galectin-9-tim-3 pathway activation tim-3/galectin-9 inhibitory interaction th17-mediated skin inflammation anti-inflammatory cytokine expression anti-tim3 antibody promotes tumor antigen-specific cd8+ exhausted virus-specific cd8 full article pdf cd8 t-cell responses il-21 mediate cross-regulation cd8 t-cell exhaustion dual tim-3/pd-1 expression innate immune cells de jager sc t-cell apoptosis tim receptor family anti-tim-3 antibody t-cell immunoglobulin tim-3 ligand regulates t-cell ig privacy choices/manage cookies ligand-dependent manner immune system t-cell response tim-3/galectin-9 pathway sanchez-fueyo freeman gj article gorman tim-3 signaling restores tumor-specific cd8 mucin domain-1-mediated tim-3 mediates phagocytosis merkel polyomavirus-specific viral-induced immunopathology tim-1 signaling substitutes virus-specific humoral tim-3 regulates pro

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Regulation of T cell responses by the receptor molecule Tim-3
         description: Tim-3 is a member of the T cell immunoglobulin and mucin domain (Tim) family of proteins, which are expressed by several cell types in the immune system, including CD4 and CD8 T cells activated under certain conditions. These molecules are generally thought to act as receptors for multiple ligands and thus to function by engaging intracellular signaling pathways in a ligand-dependent manner. In recent years, the function of the Tim-3 protein has been studied in some detail, particularly with respect to its role in the regulation of CD4 and CD8 T cell responses. Here, we review the structural features of Tim-3, known ligands for this molecule and the links established between Tim-3 and signal transduction pathways. In addition, we review the current literature regarding the role of Tim-3 in the regulation of effector responses by CD4 and CD8 T cells. Overall, findings published thus far strongly support the conclusion that Tim-3 functions to inhibit T cell responses, particularly under conditions involving chronic stimulation. Conversely, some reports have provided evidence that Tim-3 can stimulate T cells under conditions involving acute stimulation, suggesting that the role of Tim-3 may vary depending on context. Further study of Tim-3 is likely to advance our understanding of how CD4 and CD8 T cell responses are regulated and could uncover novel approaches for manipulating T cell function for therapeutic benefit.
         datePublished:2014-05-14T00:00:00Z
         dateModified:2014-05-14T00:00:00Z
         pageStart:56
         pageEnd:65
         sameAs:https://doi.org/10.1007/s12026-014-8524-1
         keywords:
            T cells
            Tim protein family
            Surface receptor
            Signal transduction
            Immune system regulation
            Immunology
            Allergology
            Medicine/Public Health
            general
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-014-8524-1/MediaObjects/12026_2014_8524_Fig1_HTML.gif
         isPartOf:
            name:Immunologic Research
            issn:
               1559-0755
               0257-277X
            volumeNumber:59
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jacob V. Gorman
               affiliation:
                     name:University of Iowa
                     address:
                        name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John D. Colgan
               affiliation:
                     name:University of Iowa
                     address:
                        name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
                        type:PostalAddress
                     type:Organization
                     name:University of Iowa
                     address:
                        name:Departments of Internal Medicine and Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Regulation of T cell responses by the receptor molecule Tim-3
      description: Tim-3 is a member of the T cell immunoglobulin and mucin domain (Tim) family of proteins, which are expressed by several cell types in the immune system, including CD4 and CD8 T cells activated under certain conditions. These molecules are generally thought to act as receptors for multiple ligands and thus to function by engaging intracellular signaling pathways in a ligand-dependent manner. In recent years, the function of the Tim-3 protein has been studied in some detail, particularly with respect to its role in the regulation of CD4 and CD8 T cell responses. Here, we review the structural features of Tim-3, known ligands for this molecule and the links established between Tim-3 and signal transduction pathways. In addition, we review the current literature regarding the role of Tim-3 in the regulation of effector responses by CD4 and CD8 T cells. Overall, findings published thus far strongly support the conclusion that Tim-3 functions to inhibit T cell responses, particularly under conditions involving chronic stimulation. Conversely, some reports have provided evidence that Tim-3 can stimulate T cells under conditions involving acute stimulation, suggesting that the role of Tim-3 may vary depending on context. Further study of Tim-3 is likely to advance our understanding of how CD4 and CD8 T cell responses are regulated and could uncover novel approaches for manipulating T cell function for therapeutic benefit.
      datePublished:2014-05-14T00:00:00Z
      dateModified:2014-05-14T00:00:00Z
      pageStart:56
      pageEnd:65
      sameAs:https://doi.org/10.1007/s12026-014-8524-1
      keywords:
         T cells
         Tim protein family
         Surface receptor
         Signal transduction
         Immune system regulation
         Immunology
         Allergology
         Medicine/Public Health
         general
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-014-8524-1/MediaObjects/12026_2014_8524_Fig1_HTML.gif
      isPartOf:
         name:Immunologic Research
         issn:
            1559-0755
            0257-277X
         volumeNumber:59
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jacob V. Gorman
            affiliation:
                  name:University of Iowa
                  address:
                     name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John D. Colgan
            affiliation:
                  name:University of Iowa
                  address:
                     name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Iowa
                  address:
                     name:Departments of Internal Medicine and Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Immunologic Research
      issn:
         1559-0755
         0257-277X
      volumeNumber:59
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Iowa
      address:
         name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
         type:PostalAddress
      name:University of Iowa
      address:
         name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
         type:PostalAddress
      name:University of Iowa
      address:
         name:Departments of Internal Medicine and Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jacob V. Gorman
      affiliation:
            name:University of Iowa
            address:
               name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
               type:PostalAddress
            type:Organization
      name:John D. Colgan
      affiliation:
            name:University of Iowa
            address:
               name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
               type:PostalAddress
            type:Organization
            name:University of Iowa
            address:
               name:Departments of Internal Medicine and Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
      name:Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
      name:Departments of Internal Medicine and Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(393)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.51s.

LINK . SPRINGER . COM {}