We are analyzing https://link.springer.com/article/10.1007/s12026-011-8205-2.

Title:
Transcriptional regulation by STAT6 | Immunologic Research
Description:
Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. In this review, we will describe our current understanding of the biological functions of STAT6 and summarize recent advances in understanding the molecular mechanisms by which STAT6 regulates transcription.
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Keywords {🔍}

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Topics {✒️}

ccaat/enhancer-binding protein-dependent mechanism il-4-stimulated nf-kappab activity month download article/chapter c-terminal activation motifs antigen-induced airway hyperresponsiveness interleukin-4-induced gene expression il-4-induced th2 response urban jf jr immune cell regulators ap-1 transcription factors interleukin-4-induced transcription factor mediate il-4-induced activation interferon-gamma activation site stat6-dependent gene activation anti-cd40 antibody induction impaired il-13-mediated functions stat-dependent gene expression il-4/cd40 responsive element stat6 transcription factors interleukin-13-mediated host protection il-4 receptor/stat6 signaling germline epsilon promoter stat6-mediated allergic diarrhea il-4-treated mouse lymphocytes il-13-induced airway hyperreactivity mouse mammary development mammary epithelial cells full article pdf il-4 signalling enhancer-mediated control il-4/stat6 pathway ifn-responsive promoter cell-dependent mechanism privacy choices/manage cookies promoter elements eotaxin gene transcription il-4/stat6-regulated genes th2 lymphocyte differentiation immunologic functional perspective litterst cm disrupted stat6 gene interleukin-4-induced transcription dna binding factor stat6 regulates transcription il4 locus accessibility intestinal nematode parasites rna polymerase ii allergic airway disease helper cell differentiation transcription factor stat3

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         headline:Transcriptional regulation by STAT6
         description:Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. In this review, we will describe our current understanding of the biological functions of STAT6 and summarize recent advances in understanding the molecular mechanisms by which STAT6 regulates transcription.
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      description:Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. In this review, we will describe our current understanding of the biological functions of STAT6 and summarize recent advances in understanding the molecular mechanisms by which STAT6 regulates transcription.
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         Co-activators
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         general
         Internal Medicine
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