We are analyzing https://link.springer.com/article/10.1007/s12026-009-8125-6.

Title:
A multi-functional role of interferon regulatory factor-8 in solid tumor and myeloid cell biology | Immunologic Research
Description:
Understanding mechanisms of tumor escape are critically important not only to improving our knowledge of cancer biology, but also for the overall development of more effective anti-neoplastic therapies. Our laboratory focuses on mechanisms of apoptotic resistance, with emphasis on Fas loss of function as an important determinant of tumor progression. Our work in solid tumor systems has led to the identification of interferon regulatory factor-8 (IRF-8) as a differentially expressed gene important for tumor cell response to cytotoxicity, including Fas-mediated apoptosis and host–anti-tumor immunosurveillance mechanisms. Although IRF-8 was originally identified in the regulation of normal and neoplastic myeloid cell development, these findings revealed a new functional role for IRF-8 in non-hematopoietic malignancies and establish a molecular basis for its potential manipulation during cancer therapy.
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Keywords {🔍}

article, pubmed, google, scholar, cas, cancer, tumor, cells, interferon, factor, abrams, immunol, regulatory, cell, protein, irf, expression, myeloid, consensus, liu, gene, transcription, res, response, apoptosis, suppressor, icsbp, model, carcinoma, privacy, cookies, content, research, mechanisms, escape, development, access, myeloidderived, sequence, binding, immunotherapy, immunity, oncogene, mouse, human, colon, ifn, wang, publish, search,

Topics {✒️}

host–anti-tumor immunosurveillance mechanisms protracted host-tumor interactions ifn-gamma-inducible transcription factor myeloid-derived suppressor cells tumour microenvironment anti-fas interactions influences month download article/chapter fas/fas ligand interactions death receptor-initiated apoptosis interferon regulatory factor-8 interferon regulatory factor-1 interferon-gamma induces regression effective anti-neoplastic therapies ctl adoptive immunotherapy including fas-mediated apoptosis ngf/tnf receptor superfamily icsbp transcription factors fas/fas ligand pathway optimal tumor regression myeloid cell biology tumor escape aggressive tumor variants shaping tumor immunogenicity differentiating myeloid cells tumor cell response full article pdf fas-mediated apoptosis solid tumor systems human myeloid leukemias suppressing tumor development interferon-gamma response privacy choices/manage cookies che mei lin neoplastic colon epithelium activator protein-1 elements cancer immunotherapy interferon cytokine res check access instant access related subjects chronic myelogenous leukemia myeloid cells epithelial cell carcinoma cancer biology enhanced metastatic competence transgenic mouse model rpci institutional funding solid tumor european economic area pretreatment risk features

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         headline:A multi-functional role of interferon regulatory factor-8 in solid tumor and myeloid cell biology
         description:Understanding mechanisms of tumor escape are critically important not only to improving our knowledge of cancer biology, but also for the overall development of more effective anti-neoplastic therapies. Our laboratory focuses on mechanisms of apoptotic resistance, with emphasis on Fas loss of function as an important determinant of tumor progression. Our work in solid tumor systems has led to the identification of interferon regulatory factor-8 (IRF-8) as a differentially expressed gene important for tumor cell response to cytotoxicity, including Fas-mediated apoptosis and host–anti-tumor immunosurveillance mechanisms. Although IRF-8 was originally identified in the regulation of normal and neoplastic myeloid cell development, these findings revealed a new functional role for IRF-8 in non-hematopoietic malignancies and establish a molecular basis for its potential manipulation during cancer therapy.
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      headline:A multi-functional role of interferon regulatory factor-8 in solid tumor and myeloid cell biology
      description:Understanding mechanisms of tumor escape are critically important not only to improving our knowledge of cancer biology, but also for the overall development of more effective anti-neoplastic therapies. Our laboratory focuses on mechanisms of apoptotic resistance, with emphasis on Fas loss of function as an important determinant of tumor progression. Our work in solid tumor systems has led to the identification of interferon regulatory factor-8 (IRF-8) as a differentially expressed gene important for tumor cell response to cytotoxicity, including Fas-mediated apoptosis and host–anti-tumor immunosurveillance mechanisms. Although IRF-8 was originally identified in the regulation of normal and neoplastic myeloid cell development, these findings revealed a new functional role for IRF-8 in non-hematopoietic malignancies and establish a molecular basis for its potential manipulation during cancer therapy.
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