We are analyzing https://link.springer.com/article/10.1007/s12020-012-9617-z.

Title:
Obesidomics: contribution of adipose tissue secretome analysis to obesity research | Endocrine
Description:
Obesity is presently reaching pandemic proportions and it is becoming a major health concern in developed and developing countries due to its comorbidities like type II diabetes, cardiovascular pathologies, and some cancers. The discovery of the adipose tissue role as an endocrine gland able to secrete adipokines that affects whole-body energy homeostasis has become a key break-through toward a better molecular understanding of obesity. Among the known adipokines involved in the regulation of energy metabolism very few have been clearly seen as central regulators of insulin sensitivity, metabolism, and energy homeostasis. Thus, the discovery and characterization of new adipocyte-derived factors is still in progress. Proteomics technology has emerged as a useful tool to analyze adipose tissue secretion (secretome) dynamics giving a wider picture into the molecular events that control body weight. Besides the identification of new secreted proteins, the advantage of using this approach is the possibility to detect post-translational modifications and protein interactions that generally cannot be predicted by genome studies. In this review, we summarize the recent efforts to identify new bioactive adipokines by proteomics especially in pathological situations such as obesity.
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month download article/chapter pigment epithelium-derived factor adipose tissue-derived cells luisa maria seoane & felipe sequence-biased recurrent networks detect post-translational modifications santiago de compostela intrinsic depot-specific differences stromal-vascular fraction rat adipose cells arturo roca-rivada human adipose tissue visceral adipose tissue 3t3-l1 adipocytes adipose tissue role adipose tissue contributes privacy choices/manage cookies full article pdf ministerio de ciencia innovación de españa author information authors obese adipose secretome uveal melanoma research depot-specific differences adipose proteome analysis maria pardo omental adipose tissues article endocrine aims derived cell lines quantitative proteomic analysis visceral fat depots adipocyte-derived factors google scholar study tissue secretomes article pardo european economic area developing countries due control body weight related subjects hormone-dependent induction zucker obese rats differentiating human preadipocytes adipogenic progenitor abundance miguel servet fellow high-fat diet conditions privacy policy cancer cell secretome major health concern gene-environment interaction adipose tissue

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Diamandis, The cancer cell secretome: a good source for discovering biomarkers?
Jensen, Why are we shaped differently, and why does it matter?

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         description:Obesity is presently reaching pandemic proportions and it is becoming a major health concern in developed and developing countries due to its comorbidities like type II diabetes, cardiovascular pathologies, and some cancers. The discovery of the adipose tissue role as an endocrine gland able to secrete adipokines that affects whole-body energy homeostasis has become a key break-through toward a better molecular understanding of obesity. Among the known adipokines involved in the regulation of energy metabolism very few have been clearly seen as central regulators of insulin sensitivity, metabolism, and energy homeostasis. Thus, the discovery and characterization of new adipocyte-derived factors is still in progress. Proteomics technology has emerged as a useful tool to analyze adipose tissue secretion (secretome) dynamics giving a wider picture into the molecular events that control body weight. Besides the identification of new secreted proteins, the advantage of using this approach is the possibility to detect post-translational modifications and protein interactions that generally cannot be predicted by genome studies. In this review, we summarize the recent efforts to identify new bioactive adipokines by proteomics especially in pathological situations such as obesity.
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      headline:Obesidomics: contribution of adipose tissue secretome analysis to obesity research
      description:Obesity is presently reaching pandemic proportions and it is becoming a major health concern in developed and developing countries due to its comorbidities like type II diabetes, cardiovascular pathologies, and some cancers. The discovery of the adipose tissue role as an endocrine gland able to secrete adipokines that affects whole-body energy homeostasis has become a key break-through toward a better molecular understanding of obesity. Among the known adipokines involved in the regulation of energy metabolism very few have been clearly seen as central regulators of insulin sensitivity, metabolism, and energy homeostasis. Thus, the discovery and characterization of new adipocyte-derived factors is still in progress. Proteomics technology has emerged as a useful tool to analyze adipose tissue secretion (secretome) dynamics giving a wider picture into the molecular events that control body weight. Besides the identification of new secreted proteins, the advantage of using this approach is the possibility to detect post-translational modifications and protein interactions that generally cannot be predicted by genome studies. In this review, we summarize the recent efforts to identify new bioactive adipokines by proteomics especially in pathological situations such as obesity.
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