We are analyzing https://link.springer.com/article/10.1007/s12020-011-9472-3.

Title:
Evaluation of oxidative status in patients with hyperthyroidism | Endocrine
Description:
Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho = 0.223, P = 0.032), FT3 levels (rho = −0.434, P = 0.002) and FT4 levels (rho = −0.363, P = 0.003) in patients. Further, TOS levels and OSI values were correlated with TSH levels (rho = −0.245, P = 0.037; rho = −0.312, P = 0.011, respectively), FT3 levels (rho = 0.293, P = 0.017, rho = 0.505, P = 0.002, respectively), and FT4 levels (rho = 0.302, P = 0.006, rho = 0.321, P = 0.008, respectively) in patients. Duration of disease was significantly correlated with OSI values in patients (rho = 0.420, P = 0.011), while no correlation with serum TAC levels and TOS levels (P > 0.05). Oxidants are increased and antioxidants are decreased in patients with hyperthyroidism; as a result, the oxidative–antioxidative balance is shifted to the oxidative side. Increased oxidative stress may play a role in the pathogenesis of hyperthyroidism. It is believed that supplementation of antioxidant vitamins such as vitamins C and E may be helpful for these patients.
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article, google, scholar, cas, pubmed, antioxidant, thyroid, oxidative, levels, patients, hyperthyroidism, total, rho, free, clin, status, stress, rat, lipid, peroxidation, method, serum, activity, content, capacity, disease, biol, privacy, cookies, evaluation, mehmet, aslan, blood, biochem, radical, med, data, publish, search, endocrine, celik, automated, tac, tos, osi, access, hormones, liver, methods, glutathione,

Topics {✒️}

brain-homogenate autoxidation system month download article/chapter yasemin usul soyoral total oxidant status complement-attacked thyroid cells oxidative stress index free radical-mediated oxidation total antioxidant capacity cas google scholar article google scholar article endocrine aims measuring antioxidant capacity stress-induced activation privacy choices/manage cookies full article pdf serum oxidative status peripheral hypothyroid condition thyroid activity variations respiratory responses related increased oxidative stress oxidizing-stress parameters triiodothyronine-induced modification thyroid hormone oxidative–antioxidative balance free radical activity antioxidant enzyme activities antioxidant defence mechanisms free radical scavengers experimental hyperthyroid state nadph oxidase activity european economic area ahmet cumhur dulger reactive oxygen species beta-adrenergic blockers diffuse toxic guatr generous friendly assistance antioxidant levels enzyme serum malonyl dialdehyde cytochrome p-450 content yuzuncu yil university conditions privacy policy oxidative muscular injury microsomal lipid peroxidation glutathione peroxidase activities heart electrical activity lipid peroxidation activity superoxide radical generation rat lymphoid organs accepting optional cookies human blood plasma

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Halliwell, Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

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         headline:Evaluation of oxidative status in patients with hyperthyroidism
         description:Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho = 0.223, P = 0.032), FT3 levels (rho = −0.434, P = 0.002) and FT4 levels (rho = −0.363, P = 0.003) in patients. Further, TOS levels and OSI values were correlated with TSH levels (rho = −0.245, P = 0.037; rho = −0.312, P = 0.011, respectively), FT3 levels (rho = 0.293, P = 0.017, rho = 0.505, P = 0.002, respectively), and FT4 levels (rho = 0.302, P = 0.006, rho = 0.321, P = 0.008, respectively) in patients. Duration of disease was significantly correlated with OSI values in patients (rho = 0.420, P = 0.011), while no correlation with serum TAC levels and TOS levels (P > 0.05). Oxidants are increased and antioxidants are decreased in patients with hyperthyroidism; as a result, the oxidative–antioxidative balance is shifted to the oxidative side. Increased oxidative stress may play a role in the pathogenesis of hyperthyroidism. It is believed that supplementation of antioxidant vitamins such as vitamins C and E may be helpful for these patients.
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      headline:Evaluation of oxidative status in patients with hyperthyroidism
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