We are analyzing https://link.springer.com/article/10.1007/s12018-009-9033-y.

Title:
Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications | Clinical & Translational Metabolism
Description:
Although the kidney was initially thought to be the sole organ responsible for the production of 1,25(OH)2D3 via its enzyme CYP27b1, it is now appreciated that the expression of CYP27b1 in tissues other than the kidney is wide spread. However, the kidney is the major source for circulating 1,25(OH)2D3. Therefore the existence of the capacity for extra renal 1,25(OH)2D3 production begs the question why, and in particular whether the extra renal production of 1,25(OH)2D3 has physiologic importance. In this chapter this question will be discussed. First a compilation of the extra renal sites for CYP27b1 expression is provided. This is followed by a discussion of the regulation of CYP27b1 expression and activity in extra renal tissues, pointing out that such regulation is tissue specific and different from that of CYP27b1 in the kidney. Finally the physiologic significance of extra renal 1,25(OH)2D3 production is examined, with special focus on the role of CYP27b1 in regulation of cellular proliferation and differentiation, hormone secretion, and immune function. At this point the data do not clearly demonstrate an essential role for CYP27b1 expression in any tissue outside the kidney, but several examples pointing in this direction are provided. With the availability of the mouse enabling tissue-specific deletion of CYP27b1, the role of extra renal CYP27b1 expression can now be addressed definitively.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

google, scholar, pubmed, cas, article, vitamin, dihydroxyvitamin, hydroxyvitamin, human, expression, alphahydroxylase, clin, cancer, cells, cypb, endocrinol, gene, cell, res, production, regulation, metab, alpha, receptor, renal, dalphahydroxylase, bone, differentiation, biol, bikle, kidney, invest, metabolism, synthesis, mol, tissue, role, keratinocytes, extra, activity, disease, evidence, extrarenal, usa, endocrinology, macrophages, dermatol, normal, biochem, immune,

Topics {✒️}

25-hydroxyvitamin d-1-alpha-hydroxylase mrna 25-hydroxyvitamin d-1alpha-hydroxylase gene encoding 25-hydroxyvitamin d-1alpha-hydroxylase month download article/chapter 25-hydroxyvitamin d3-1alpha-hydroxylase expression pancreatic beta-cell function pseudovitamin d-deficiency rickets 25-hydroxyvitamin d-1alpha-hydroxylase 1alpha-hydroxylase gene promoter 25-hydroxyvitamin d-1 alpha-hydroxylase article clinical reviews chronic renal failure androgen-independent prostate cancer kidney aok-b50 cells reduced 1alpha-hydroxylase activity 1-alpha-hydroxylase gene maps renal-gastrointestinal-skeletal axis vitamin d-dependent mechanism double-blinded randomized study 25-hydroxyvitamin d3–1alpha-hydroxylase 25 hydroxyvitamin d3–1alpha-hydroxylase 25-hydroxyvitamin d3 1alpha-hydroxylase 25-hydroxyvitamin-d3–1alpha-hydroxylase 25-dihydroxyvitamin d-mediated hypercalcemia vitamin d-mediated hypercalcemia extra-renal 1 alpha-hydroxylation 25-hydroxyvitamin d3–1 alpha-hydroxylase severe secondary/tertiary hyperparathyroidism full article pdf p450 cytochrome 25-hydroxyvitamin metabolic drug clearance interferon-gamma-mediated induction perfused rat pancreas article bikle cultured human keratinocytes pathological parathyroid glands privacy choices/manage cookies cultured alveolar macrophages 1alpha-hydroxylase gene vitamin d-24-hydroxylase extra renal sites related subjects antimicrobial peptide expression human keratinocytes varies normal insulin secretion renal impairment influence specifies tumor type prostate cancer mortality chemically induced tumorigenesis uv-induced tumorigenesis

Questions {❓}

Do tissues other than the kidney produce 1, 25-dihydroxyvitamin D3 in vivo?
Gene amplification and splice variants of 25-hydroxyvitamin D3 1, alpha-hydroxylase (CYP27B1) in glioblastoma multiforme—a possible role in tumor progression?
Is vitamin D deficiency to blame for the asthma epidemic?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications
         description:Although the kidney was initially thought to be the sole organ responsible for the production of 1,25(OH)2D3 via its enzyme CYP27b1, it is now appreciated that the expression of CYP27b1 in tissues other than the kidney is wide spread. However, the kidney is the major source for circulating 1,25(OH)2D3. Therefore the existence of the capacity for extra renal 1,25(OH)2D3 production begs the question why, and in particular whether the extra renal production of 1,25(OH)2D3 has physiologic importance. In this chapter this question will be discussed. First a compilation of the extra renal sites for CYP27b1 expression is provided. This is followed by a discussion of the regulation of CYP27b1 expression and activity in extra renal tissues, pointing out that such regulation is tissue specific and different from that of CYP27b1 in the kidney. Finally the physiologic significance of extra renal 1,25(OH)2D3 production is examined, with special focus on the role of CYP27b1 in regulation of cellular proliferation and differentiation, hormone secretion, and immune function. At this point the data do not clearly demonstrate an essential role for CYP27b1 expression in any tissue outside the kidney, but several examples pointing in this direction are provided. With the availability of the mouse enabling tissue-specific deletion of CYP27b1, the role of extra renal CYP27b1 expression can now be addressed definitively.
         datePublished:2009-03-18T00:00:00Z
         dateModified:2009-03-18T00:00:00Z
         pageStart:114
         pageEnd:125
         sameAs:https://doi.org/10.1007/s12018-009-9033-y
         keywords:
            CYP27b1
            Proliferation
            Differentiation
            Parathyroid hormone
            Insulin
            FGF23
            Immune function
            Cancer
            Keratinocytes
            Macrophages
            Endocrinology
            Orthopedics
            Rheumatology
            Gynecology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig4_HTML.gif
         isPartOf:
            name:Clinical Reviews in Bone and Mineral Metabolism
            issn:
               1559-0119
               1534-8644
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Humana Press Inc
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Daniel D. Bikle
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications
      description:Although the kidney was initially thought to be the sole organ responsible for the production of 1,25(OH)2D3 via its enzyme CYP27b1, it is now appreciated that the expression of CYP27b1 in tissues other than the kidney is wide spread. However, the kidney is the major source for circulating 1,25(OH)2D3. Therefore the existence of the capacity for extra renal 1,25(OH)2D3 production begs the question why, and in particular whether the extra renal production of 1,25(OH)2D3 has physiologic importance. In this chapter this question will be discussed. First a compilation of the extra renal sites for CYP27b1 expression is provided. This is followed by a discussion of the regulation of CYP27b1 expression and activity in extra renal tissues, pointing out that such regulation is tissue specific and different from that of CYP27b1 in the kidney. Finally the physiologic significance of extra renal 1,25(OH)2D3 production is examined, with special focus on the role of CYP27b1 in regulation of cellular proliferation and differentiation, hormone secretion, and immune function. At this point the data do not clearly demonstrate an essential role for CYP27b1 expression in any tissue outside the kidney, but several examples pointing in this direction are provided. With the availability of the mouse enabling tissue-specific deletion of CYP27b1, the role of extra renal CYP27b1 expression can now be addressed definitively.
      datePublished:2009-03-18T00:00:00Z
      dateModified:2009-03-18T00:00:00Z
      pageStart:114
      pageEnd:125
      sameAs:https://doi.org/10.1007/s12018-009-9033-y
      keywords:
         CYP27b1
         Proliferation
         Differentiation
         Parathyroid hormone
         Insulin
         FGF23
         Immune function
         Cancer
         Keratinocytes
         Macrophages
         Endocrinology
         Orthopedics
         Rheumatology
         Gynecology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12018-009-9033-y/MediaObjects/12018_2009_9033_Fig4_HTML.gif
      isPartOf:
         name:Clinical Reviews in Bone and Mineral Metabolism
         issn:
            1559-0119
            1534-8644
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Humana Press Inc
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Daniel D. Bikle
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Clinical Reviews in Bone and Mineral Metabolism
      issn:
         1559-0119
         1534-8644
      volumeNumber:7
Organization:
      name:Humana Press Inc
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of California, San Francisco
      address:
         name:Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Daniel D. Bikle
      affiliation:
            name:University of California, San Francisco
            address:
               name:Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(419)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.35s.

LINK . SPRINGER . COM {}