We are analyzing https://link.springer.com/article/10.1007/s12015-022-10327-x.

Title:
Mesenchymal Stem Cell Derived Exosomes Suppress Neuronal Cell Ferroptosis Via lncGm36569/miR-5627-5p/FSP1 Axis in Acute Spinal Cord Injury | Stem Cell Reviews and Reports
Description:
Exosomes derived from mesenchymal stem cells (MSCs) have been considered as an alternative for cell therapy of acute spinal cord injury (ASCI). However, the underlying mechanism remains unclear. Here, ASCI mouse model and hypoxic cell model were established to evaluate the effects of MSCs and MSCs-derived exosomes (MSCs-exo). The results showed that both MSCs and MSCs-exo inhibited the production of ROS and ferrous iron, upregulated the expression of ferroptosis suppressor FSP1, and enhanced repair of neurological function in the ASCI mice. Besides, MSCs and MSCs-exo attenuated hypoxia-induced neuronal cell ferroptosis and increased cell proliferation. Further study demonstrated that lncGm36569 was enriched in the MSCs-exo. Through bioinformatics analysis and luciferase assay, we confirmed that lncGm36569 acted as a competitive RNA of miR-5627-5p to induce FSP1 upregulation. Furthermore, overexpression of miR-5627-5p reversed the therapeutic effects of lncGm36569 on neuronal cell ferroptosis. In conclusion, MSCs-exosomes lncGm36569 inhibited neuronal cell ferroptosis through miR-5627-5p/FSP1 axis, thereby attenuating neuronal dysfunction. Graphical Abstract
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Keywords {🔍}

pubmed, article, google, scholar, spinal, cord, injury, cell, stem, cas, ferroptosis, cells, central, journal, mesenchymal, chen, acute, liu, wang, exosomes, research, yang, zhao, recovery, zhang, promotes, nature, cancer, reviews, zhou, derived, neuronal, mscs, model, access, bone, functional, rats, experimental, privacy, cookies, content, data, axis, shao, mouse, mscsexo, study, lncgm, neurotrauma,

Topics {✒️}

lncgm36569/mir-5627-5p/fsp1 axis mesenchymal stem cells mir-5627-5p/fsp1 axis mesenchymal stromal cells mir-150-5p/slc38a1 axis wiley-blackwell online open month download article/chapter mmp2/stat3 related astrogliosis stem cell therapy stem cell rev neuronal cell ferroptosis stem cell therapies stem cells mscs-derived exosomes neural regeneration research mir-5627-5p reversed spinal cord injury nucleus pulposus cells mscs-exo inhibited attenuating neuronal dysfunction colorectal cancer cells ferroptosis suppressor fsp1 full article pdf acute brain injury promotes functional recovery increased cell proliferation tengyue yang & dongzhe li nonapoptotic cell death mir-5627-5p chenglong shao wrote spinal cord medicine ros-induced p38mapk induce fsp1 upregulation deliver anti-inflammatory anti-scarring activities mir-132/derlin-1 pathway extracellular vesicles fth1 inhibits ferroptosis exosomes derived cell culture supernatants promote cell migration privacy choices/manage cookies scaffold based transplantation motor performance score related subjects long noncoding rnas hypoxic cell model deferoxamine promotes recovery basso mouse scale competing endogenous rna

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         description:Exosomes derived from mesenchymal stem cells (MSCs) have been considered as an alternative for cell therapy of acute spinal cord injury (ASCI). However, the underlying mechanism remains unclear. Here, ASCI mouse model and hypoxic cell model were established to evaluate the effects of MSCs and MSCs-derived exosomes (MSCs-exo). The results showed that both MSCs and MSCs-exo inhibited the production of ROS and ferrous iron, upregulated the expression of ferroptosis suppressor FSP1, and enhanced repair of neurological function in the ASCI mice. Besides, MSCs and MSCs-exo attenuated hypoxia-induced neuronal cell ferroptosis and increased cell proliferation. Further study demonstrated that lncGm36569 was enriched in the MSCs-exo. Through bioinformatics analysis and luciferase assay, we confirmed that lncGm36569 acted as a competitive RNA of miR-5627-5p to induce FSP1 upregulation. Furthermore, overexpression of miR-5627-5p reversed the therapeutic effects of lncGm36569 on neuronal cell ferroptosis. In conclusion, MSCs-exosomes lncGm36569 inhibited neuronal cell ferroptosis through miR-5627-5p/FSP1 axis, thereby attenuating neuronal dysfunction.
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      description:Exosomes derived from mesenchymal stem cells (MSCs) have been considered as an alternative for cell therapy of acute spinal cord injury (ASCI). However, the underlying mechanism remains unclear. Here, ASCI mouse model and hypoxic cell model were established to evaluate the effects of MSCs and MSCs-derived exosomes (MSCs-exo). The results showed that both MSCs and MSCs-exo inhibited the production of ROS and ferrous iron, upregulated the expression of ferroptosis suppressor FSP1, and enhanced repair of neurological function in the ASCI mice. Besides, MSCs and MSCs-exo attenuated hypoxia-induced neuronal cell ferroptosis and increased cell proliferation. Further study demonstrated that lncGm36569 was enriched in the MSCs-exo. Through bioinformatics analysis and luciferase assay, we confirmed that lncGm36569 acted as a competitive RNA of miR-5627-5p to induce FSP1 upregulation. Furthermore, overexpression of miR-5627-5p reversed the therapeutic effects of lncGm36569 on neuronal cell ferroptosis. In conclusion, MSCs-exosomes lncGm36569 inhibited neuronal cell ferroptosis through miR-5627-5p/FSP1 axis, thereby attenuating neuronal dysfunction.
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         Regenerative Medicine/Tissue Engineering
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