We are analyzing https://link.springer.com/article/10.1007/s12013-014-0034-1.

Title:
The Levels of Ki-67 Positive are Positively Associated with Lymph Node Metastasis in Invasive Ductal Breast Cancer | Cell Biochemistry and Biophysics
Description:
Breast cancer is the most common cancer in women worldwide. In this study, we evaluate the potential risk factors for lymph node metastasis in invasive breast cancer patients with axillary dissection. 147 patients were included into this prospective study. The prognostic biomarkers including Ki-67, human epidermal growth factor receptor 2 (HER-2), hormone receptor status, p53, and lymph node involvement were determined by immunohistochemistry. The association between lymph node metastasis and these biomarkers was analyzed. Lymph node metastasis was found in 62 patients out of 147 patients. The high levels of Ki-67 positive (greater than 20 %) were positively correlated with a higher incidence of lymph node metastasis, including the numbers of lymph nodes that contain tumor cells and the lymph node metastatic rate. The high rate of positive lymphovascular invasion (LVI) is associated with lymph node metastasis. However, the levels of Ki-67 positive were not correlated with the positive rate of LVI. There was also no association between lymph node metastasis and other prognostic biomarkers, such as HER-2, estrogen receptor, progesterone receptor, and p53. In addition, apart from p53, the levels of Ki-67 positive were correlated with other prognostic biomarkers. Our data suggest that Ki-67 positivity has value as a prognostic and predictive biomarker in breast cancer and may be a valuable proliferation marker in routine diagnosis of breast cancer.
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Keywords {🔍}

cancer, breast, article, pubmed, google, scholar, cas, journal, oncology, lymph, patients, node, prognostic, clinical, metastasis, research, cell, study, positive, receptor, proliferation, expression, biomarkers, marker, markers, chemotherapy, tumor, therapy, central, privacy, cookies, content, levels, invasive, status, access, early, data, including, information, publish, search, yin, zeng, predictive, international, medicine, relationship, survival, protein,

Topics {✒️}

month download article/chapter triple-negative breast cancer node-negative breast cancer flow cytometric s-phase decreased post-relapse survival article cell biochemistry nanjing medical university tumor-related prognostic factors neoadjuvant anthracycline-based chemotherapy c-erbb-2 protein expression hormone receptor status full article pdf aromatase inhibitor letrozole specific prognostic factor privacy choices/manage cookies lymph node metastasis invasive breast cancer lymph node involvement endocrine-related cancer steroid receptor expression breast cancer research related subjects estrogen receptor status min zhao recurrent breast cancer human breast cancer nuclear protein detected potential risk factors ki-67 protein coincide early breast cancer iii breast cancer operable breast cancer metastatic breast cancer breast cancer subtypes anthracycline dose intensity positive lymphovascular invasion breast-conserving therapy national cancer institute article yin mib-1 proliferation index peritumoral vascular invasion blood vascular invasion large case series long-term follow clinical cancer research valuable proliferation marker conditions privacy policy proliferative activity evaluated endocrine therapy failure proliferation marker ki-67

Questions {❓}

Is Ki67 Effective as a Prognostic Marker in Node-Positive Breast Cancer Patients?
Proliferative markers as prognostic and predictive tools in early breast cancer: Where are we now?

Schema {🗺️}

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         description:Breast cancer is the most common cancer in women worldwide. In this study, we evaluate the potential risk factors for lymph node metastasis in invasive breast cancer patients with axillary dissection. 147 patients were included into this prospective study. The prognostic biomarkers including Ki-67, human epidermal growth factor receptor 2 (HER-2), hormone receptor status, p53, and lymph node involvement were determined by immunohistochemistry. The association between lymph node metastasis and these biomarkers was analyzed. Lymph node metastasis was found in 62 patients out of 147 patients. The high levels of Ki-67 positive (greater than 20 %) were positively correlated with a higher incidence of lymph node metastasis, including the numbers of lymph nodes that contain tumor cells and the lymph node metastatic rate. The high rate of positive lymphovascular invasion (LVI) is associated with lymph node metastasis. However, the levels of Ki-67 positive were not correlated with the positive rate of LVI. There was also no association between lymph node metastasis and other prognostic biomarkers, such as HER-2, estrogen receptor, progesterone receptor, and p53. In addition, apart from p53, the levels of Ki-67 positive were correlated with other prognostic biomarkers. Our data suggest that Ki-67 positivity has value as a prognostic and predictive biomarker in breast cancer and may be a valuable proliferation marker in routine diagnosis of breast cancer.
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