Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s12011-021-02954-1.

Title:
DNA Methylation Profiles of Ovarian Granular Cells from Fluorosis Female Patients Suffering Reproductive Dysfunctions | Biological Trace Element Research
Description:
Fluorosis often causes female reproductive dysfunction. A rapid turnover of DNA methylation is a pathological change in many human diseases, including female reproductive dysfunction. The role of DNA methylation in fluorosis was unknown and investigated in this experiment. Fifty fluorosis women patients were selected as High F group and forty-six healthy women were recruited as Control group were enrolled. In addition, ovarian granulosa cells were obtained from five women in High F group and five women in Control group. All ten women went through in vitro fertilization (IVF) process with DNA methylation sequencing. KGN cells (human granulosa cell line) were cultured with different concentrations of sodium fluoride (0–8 mM NaF) for 24 h for the in vitro study. The level of DNA methylation in blood samples was significantly higher in High F group than that in Control group. The level of serum estradiol (E2) was significantly lower in women from High F group, while the levels of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in High F group were significantly higher than that in Control group. The methylation sequences of KGN cells relating to autophagy were significantly changed by NaF treatment dose-dependently. Based on these results, it is concluded that DNA methylation and autophagy may play a significant role in the pathophysiology of reproductive dysfunction caused by fluorosis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Science
  • Social Networks

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {šŸ’ø}

We're unsure if the website is profiting.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {šŸ”}

article, google, scholar, pubmed, cas, chen, methylation, dna, cells, fluoride, wang, ovarian, fluorosis, dong, zhang, group, autophagy, china, reproductive, cell, health, xian, trace, dysfunction, women, high, shaanxi, content, patients, control, granulosa, access, environ, biol, httpsdoiorgs, mol, university, privacy, cookies, research, sequencing, blood, liu, toxicol, res, science, author, jiaotong, analysis, information,

Topics {āœ’ļø}

month download article/chapter dna methylation profiles dna methylation sequencing female reproductive dysfunction fluoride-induced mitochondrial dysfunction reproductive dysfunction caused epigenome-wide association study aberrant dna methylation serum dna methylation dna methylation dynamics naf treatment dose-dependently microrna profile full article pdf dna methylation level related subjects women suffering fluorosis dna methylation ovarian granulosa cells somatic cell functions privacy choices/manage cookies ovarian granular cells chinese han population check access instant access serum luteinizing hormone follicle-stimulating hormone chen chen chem-biol interact 315 tumor suppressor death international cooperation foundation mouse sertoli cells european economic area mouse oocytes superovulated subsequent embryonic development p38 mapk activation cyclind-cdk4-p21 cryptogenic hepatocellular carcinomas cryptogenic hepatocellular carcinoma maternal gestational diabetes epigenetics meets metabolomics sirt1/nrf2 pathway cuscuta chinensis flavonoids pi3k/akt pathway pi3k-akt pathway family planning commission yanta western road ethics declarations conflict kgn cells relating qun chen conditions privacy policy

Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:DNA Methylation Profiles of Ovarian Granular Cells from Fluorosis Female Patients Suffering Reproductive Dysfunctions
         description:Fluorosis often causes female reproductive dysfunction. A rapid turnover of DNA methylation is a pathological change in many human diseases, including female reproductive dysfunction. The role of DNA methylation in fluorosis was unknown and investigated in this experiment. Fifty fluorosis women patients were selected as High F group and forty-six healthy women were recruited as Control group were enrolled. In addition, ovarian granulosa cells were obtained from five women in High F group and five women in Control group. All ten women went through in vitro fertilization (IVF) process with DNA methylation sequencing. KGN cells (human granulosa cell line) were cultured with different concentrations of sodium fluoride (0–8Ā mM NaF) for 24Ā h for the in vitro study. The level of DNA methylation in blood samples was significantly higher in High F group than that in Control group. The level of serum estradiol (E2) was significantly lower in women from High F group, while the levels of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in High F group were significantly higher than that in Control group. The methylation sequences of KGN cells relating to autophagy were significantly changed by NaF treatment dose-dependently. Based on these results, it is concluded that DNA methylation and autophagy may play a significant role in the pathophysiology of reproductive dysfunction caused by fluorosis.
         datePublished:2021-10-22T00:00:00Z
         dateModified:2021-10-22T00:00:00Z
         pageStart:3529
         pageEnd:3536
         sameAs:https://doi.org/10.1007/s12011-021-02954-1
         keywords:
            DNA methylation
            Methylation sequencing
            QMSP
            Fluorosis
            Autophagy
            Biochemistry
            general
            Biotechnology
            Nutrition
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig5_HTML.png
         isPartOf:
            name:Biological Trace Element Research
            issn:
               1559-0720
               0163-4984
            volumeNumber:200
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Biqi He
               affiliation:
                     name:Xi’an Jiaotong University
                     address:
                        name:Class 0128, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Siyuan Dong
               affiliation:
                     name:Xi’an Jiaotong University
                     address:
                        name:Class S0141, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qun Chen
               url:http://orcid.org/0000-0001-8638-2908
               affiliation:
                     name:School of Public Health, Xi’an Jiaotong University Health Science Center
                     address:
                        name:Institute of Endemic Diseases, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People’s Republic of China, Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Zhaoheng Dong
               affiliation:
                     name:Shandong Shenghua Electronic New Materials Co., Ltd.
                     address:
                        name:Shandong Shenghua Electronic New Materials Co., Ltd., Yantai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chen Chen
               affiliation:
                     name:University of Queensland
                     address:
                        name:Endocrinology, School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:DNA Methylation Profiles of Ovarian Granular Cells from Fluorosis Female Patients Suffering Reproductive Dysfunctions
      description:Fluorosis often causes female reproductive dysfunction. A rapid turnover of DNA methylation is a pathological change in many human diseases, including female reproductive dysfunction. The role of DNA methylation in fluorosis was unknown and investigated in this experiment. Fifty fluorosis women patients were selected as High F group and forty-six healthy women were recruited as Control group were enrolled. In addition, ovarian granulosa cells were obtained from five women in High F group and five women in Control group. All ten women went through in vitro fertilization (IVF) process with DNA methylation sequencing. KGN cells (human granulosa cell line) were cultured with different concentrations of sodium fluoride (0–8Ā mM NaF) for 24Ā h for the in vitro study. The level of DNA methylation in blood samples was significantly higher in High F group than that in Control group. The level of serum estradiol (E2) was significantly lower in women from High F group, while the levels of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in High F group were significantly higher than that in Control group. The methylation sequences of KGN cells relating to autophagy were significantly changed by NaF treatment dose-dependently. Based on these results, it is concluded that DNA methylation and autophagy may play a significant role in the pathophysiology of reproductive dysfunction caused by fluorosis.
      datePublished:2021-10-22T00:00:00Z
      dateModified:2021-10-22T00:00:00Z
      pageStart:3529
      pageEnd:3536
      sameAs:https://doi.org/10.1007/s12011-021-02954-1
      keywords:
         DNA methylation
         Methylation sequencing
         QMSP
         Fluorosis
         Autophagy
         Biochemistry
         general
         Biotechnology
         Nutrition
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12011-021-02954-1/MediaObjects/12011_2021_2954_Fig5_HTML.png
      isPartOf:
         name:Biological Trace Element Research
         issn:
            1559-0720
            0163-4984
         volumeNumber:200
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Biqi He
            affiliation:
                  name:Xi’an Jiaotong University
                  address:
                     name:Class 0128, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Siyuan Dong
            affiliation:
                  name:Xi’an Jiaotong University
                  address:
                     name:Class S0141, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qun Chen
            url:http://orcid.org/0000-0001-8638-2908
            affiliation:
                  name:School of Public Health, Xi’an Jiaotong University Health Science Center
                  address:
                     name:Institute of Endemic Diseases, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People’s Republic of China, Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Zhaoheng Dong
            affiliation:
                  name:Shandong Shenghua Electronic New Materials Co., Ltd.
                  address:
                     name:Shandong Shenghua Electronic New Materials Co., Ltd., Yantai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen Chen
            affiliation:
                  name:University of Queensland
                  address:
                     name:Endocrinology, School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Biological Trace Element Research
      issn:
         1559-0720
         0163-4984
      volumeNumber:200
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Xi’an Jiaotong University
      address:
         name:Class 0128, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
         type:PostalAddress
      name:Xi’an Jiaotong University
      address:
         name:Class S0141, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
         type:PostalAddress
      name:School of Public Health, Xi’an Jiaotong University Health Science Center
      address:
         name:Institute of Endemic Diseases, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People’s Republic of China, Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
         type:PostalAddress
      name:Shandong Shenghua Electronic New Materials Co., Ltd.
      address:
         name:Shandong Shenghua Electronic New Materials Co., Ltd., Yantai, China
         type:PostalAddress
      name:University of Queensland
      address:
         name:Endocrinology, School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Biqi He
      affiliation:
            name:Xi’an Jiaotong University
            address:
               name:Class 0128, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Siyuan Dong
      affiliation:
            name:Xi’an Jiaotong University
            address:
               name:Class S0141, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Qun Chen
      url:http://orcid.org/0000-0001-8638-2908
      affiliation:
            name:School of Public Health, Xi’an Jiaotong University Health Science Center
            address:
               name:Institute of Endemic Diseases, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People’s Republic of China, Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zhaoheng Dong
      affiliation:
            name:Shandong Shenghua Electronic New Materials Co., Ltd.
            address:
               name:Shandong Shenghua Electronic New Materials Co., Ltd., Yantai, China
               type:PostalAddress
            type:Organization
      name:Chen Chen
      affiliation:
            name:University of Queensland
            address:
               name:Endocrinology, School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Australia
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Class 0128, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
      name:Class S0141, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an, People’s Republic of China
      name:Institute of Endemic Diseases, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People’s Republic of China, Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
      name:Shandong Shenghua Electronic New Materials Co., Ltd., Yantai, China
      name:Endocrinology, School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Australia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {šŸ”—}(143)

Analytics and Tracking {šŸ“Š}

  • Google Tag Manager

Libraries {šŸ“š}

  • Clipboard.js
  • Prism.js

CDN Services {šŸ“¦}

  • Crossref

3.96s.