We are analyzing https://link.springer.com/article/10.1007/s11999-008-0243-2.

Title:
Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma | Clinical Orthopaedics and Related Research®
Description:
Historically, osteosarcoma has been a problematic metastatic disease, with 40–80% of patients developing pulmonary metastasis after primary tumor resection. Recent treatment advancements have reduced the occurrence of metastatic lesions to less than 30%. Using attenuated Salmonella typhimurium, we previously demonstrated regression in tumor burden in murine solid tumor and metastatic models. We established a murine model for metastatic osteosarcoma to determine the effect of treatment with a single oral dose of attenuated S. typhimurium with (SalpIL2) and without (Sal-NG) a gene for a truncated human interleukin-2. Female balb/c mice were administered 2 × 105 (ATCC K7M2) osteosarcoma cells via tail vein injection from culture and treated by oral gavage of Salmonella species 3 days later. Mice were harvested for splenic lymphocytes and tumor enumeration by intratracheal injection with India ink 21 days after injection. Treatment with attenuated SalpIL2 reduced pulmonary metastases in number and volume compared to saline controls. Furthermore, splenic natural killer cell populations were increased 93% with SalpIL2 and 114% with Sal-NG compared to nontreated groups. This pulmonary metastasis model demonstrates attenuated Salmonella typhimurium with human interleukin-2 reduced metastatic osteosarcoma in mice and confirm the need for further investigation into the immunologic properties of SalpIL2 as a possible treatment for metastatic osteosarcoma.
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Keywords {🔍}

article, google, scholar, pubmed, cas, salmonella, cancer, typhimurium, osteosarcoma, attenuated, interleukin, leonard, saltzman, gene, tumor, metastatic, surg, pulmonary, metastases, murine, research, treatment, sorenson, access, bone, antitumor, clin, privacy, cookies, content, related, phd, patients, model, human, pediatr, curtiss, kelly, pediatric, oncol, author, information, publish, search, metastasis, reduced, oral, salpil, splenic, agent,

Topics {✒️}

month download article/chapter liposome-dna complexes encoding article clinical orthopaedics therapeutic cancer vaccines pulmonary metastases identification high-dose therapy clin exp metastasis soto lj 3rd bone joint surg primary bone osteosarcoma full article pdf attenuated salmonella typhimurium privacy choices/manage cookies tumor-targeted salmonella pulmonary metastatic potential related research brent unresectable hepatic metastases attenuated salmonella engineered cancer gene ther osteosarcoma lung metastases salmonella vaccine strain hum gene ther breast cancer vaccine anaerobic salmonella typhimurium oral salmonella typhimurium vivo antigen delivery pulmonary metastases feltis ba solis sj rosenberg sa truncated human interleukin-2 high level expression decreases tumor burden high-dose interleukin-2 salmonella species 3 days saline controls cyclooxygenase-2 inhibition augments high-dose methotrexate adenovector-mediated delivery cancer treat rev cancer biother radiopharm national cancer institute single oral dose anti-tumor agent european economic area selected papers presented previously demonstrated regression india ink 21 days dis colon rectum minnesota cancer center

Questions {❓}

Antitumor mechanisms of attenuated salmonella typhimurium containing the gene for human interleukin-2: a novel antitumor agent?

Schema {🗺️}

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