We are analyzing https://link.springer.com/article/10.1007/s11926-004-0012-5.

Title:
New advances in measurement of complement activation: Lessons of systemic lupus erythematosus | Current Rheumatology Reports
Description:
Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is still debated. During this same timespan, knowledge of the complement system has exploded, with identification of more than 30 proteins, an abundance of newly recognized functions, and even a third pathway of activation. These advances suggest that it is appropriate to revisit the complement system as a potential source of biomarkers for SLE. This paper reviews briefly the role of complement in SLE and other inflammatory diseases, discusses conventional methods for complement measurement and their drawbacks, and focuses on recent advancements in harnessing the complement system for monitoring SLE. Specifically, novel assays that measure cell-bound complement activation products are introduced and their utility as biomarkers of SLE disease activity is discussed.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

complement, lupus, google, scholar, systemic, erythematosus, article, cas, pubmed, disease, activation, activity, rheum, sle, immunol, manzi, arthritis, system, products, patients, access, med, rheumatol, privacy, cookies, content, liu, serum, engl, dis, clin, levels, publish, search, measurement, joseph, ahearn, biomarkers, walport, ann, curr, tests, navratil, data, information, log, journal, research, rheumatology, reports,

Topics {✒️}

month download article/chapter c5/c3 convertase activity age-specific incidence rates systemic lupus erythematosus precipitating anti-dna antibody systemic lupus erythmatosus full article pdf lupus disease activity privacy choices/manage cookies complement activation products compelment split products complement system plays central nervous system related subjects complement related chido vitro complement activation monitoring disease activity article liu check access instant access european economic area newly recognized functions paper reviews briefly ibrahim-stappers jlm cerebrospinal fluid c3 acute phase response futhan/edta controls dna-binidng capacity elicit vascular injury cardiovascular disease [abstract] erythrocyte complement receptors sle disease activity anti dsdna antibody walport ml conditions privacy policy susan manzi md c4a anaphylatoxin levels discusses conventional methods potential therapeutic target serum complement concentrations diseases involving autoantibodies article log immune complex determinations circulating immune complexes c3b/c4b receptor accepting optional cookies acute-phase proteins routine immunologic tests serum c3 levels walport mj

Questions {❓}

Routine immunologic tests in systemic lupus erythematosus: is there a need for more studies?

Schema {🗺️}

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         description:Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is still debated. During this same timespan, knowledge of the complement system has exploded, with identification of more than 30 proteins, an abundance of newly recognized functions, and even a third pathway of activation. These advances suggest that it is appropriate to revisit the complement system as a potential source of biomarkers for SLE. This paper reviews briefly the role of complement in SLE and other inflammatory diseases, discusses conventional methods for complement measurement and their drawbacks, and focuses on recent advancements in harnessing the complement system for monitoring SLE. Specifically, novel assays that measure cell-bound complement activation products are introduced and their utility as biomarkers of SLE disease activity is discussed.
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