We are analyzing https://link.springer.com/article/10.1007/s11912-020-0887-y.

Title:
Dashing Decades of Defeat: Long Anticipated Advances in the First-line Treatment of Extensive-Stage Small Cell Lung Cancer | Current Oncology Reports
Description:
Purpose of Review Small cell lung cancer (SCLC) is an exceptionally lethal subtype of lung cancer. For patients with extensive-stage (ES) disease, which is the majority of patients, platinum-doublet chemotherapy has been the standard of care for decades. Dozens of phase III trials have failed to improve survival over standard platinum plus etoposide. Recent results, however, have met with long-overdue success. This manuscript reviews the new standards of care for ES-SCLC. Recent Findings Two recent phase III trials have shown an improvement in overall survival with concurrent immunotherapy and chemotherapy. In IMpower 133, the addition of the anti-PD-L1 antibody atezolizumab to carboplatin plus etoposide significantly improved both progression-free survival (PFS) and overall survival (OS). This was the first trial in over 30 years to improve survival. In CASPIAN, concurrent durvalumab, another anti-PD-L1 antibody, also led to an improvement in survival. Summary While there is clearly a need to further improve outcomes, the improvement in survival with the addition of atezolizumab or durvalumab to platinum-doublet chemotherapy is a major advance. We now have new standards of care and the potential of a more meaningful benefit for patients with advanced SCLC.
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Keywords {🔍}

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Topics {✒️}

extensive-disease-small-cell lung cancer granulocyte colony-stimulating factor small-cell lung cancer small-cell lung cancer anti-pd-l1 antibody atezolizumab month download article/chapter belotecan/cisplatin versus etoposide/cisplatin amrubicin/cisplatin versus etoposide/cisplatin anti-pd-l1 antibody goirc-aifa farm6pmfjm trial current cancer research anti-pd-l1 antibodies lung cancer access extensive-stage sclc previously untreated patients progression-free survival springer international publishing phase iii trials full article pdf phase iii trial clin lung cancer standard versus alternating extensive-stage extensive disease phase iii study southwest oncology group randomized controlled trial privacy choices/manage cookies doxorubicin-based chemotherapy compared maintenance immunotherapy study shepherd fa cisplatin versus alternation natl cancer inst national cancer institute piha-paul sa pd-l1 expression lung cancer received research funding dashing decades phase ii study additional information publisher topotecan versus observation single-agent amrubicin standard-dose etoposide cisplatin-based chemotherapy de braud fg important negative result article armstrong randomized trials multicenter retrospective analysis

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Is there a case for cisplatin in the treatment of small-cell lung cancer?

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