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Title:
Diagnosis and treatment of Wilson’s disease | Current Neurology and Neuroscience Reports
Description:
Wilson’s disease (WD) is an autosomal recessive disease that causes increased copper deposition in the liver and basal ganglia with resultant hepatic and neurologic sequelae. In the past few years, dramatic new discoveries have changed our understanding of the pathophysiology of WD. Although there are potentially life-saving therapies for WD, there is much controversy surrounding the optimal treatments of patients in the various stages of the disease. Specifically, the relative roles of penicillamine, trientene, and tetrathiomolybdate in the initial treatment of the symptomatic patient with WD remain to be defined. Zinc monotherapy for maintenance treatment and in the treatment of asymptomatic patients with WD is still controversial. It is also unclear whether neurologic status alone is an indication for liver transplantation in WD. This paper reviews the pathogenesis, genetics, clinical presentation, and diagnosis, with a special emphasis on the treatment controversies that arise in the care of the WD patient.
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disease, google, scholar, cas, pubmed, wilsons, article, treatment, liver, wilson, copper, diagnosis, patients, zinc, walshe, neurol, brewer, transplantation, gene, med, neurology, penicillamine, initial, clin, dick, johnson, privacy, cookies, content, neurological, therapy, genet, choice, analysis, publish, search, hepatic, clinical, access, chapter, degeneration, brain, gitlin, study, arch, author, data, information, log, journal,
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Questions {❓}
- Brewer GJ, Yuzbasiyan-Gurkan V, Dick R, Wang Y, Johnson V: Does a vegetarian diet control Wilson’s disease?
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description:Wilson’s disease (WD) is an autosomal recessive disease that causes increased copper deposition in the liver and basal ganglia with resultant hepatic and neurologic sequelae. In the past few years, dramatic new discoveries have changed our understanding of the pathophysiology of WD. Although there are potentially life-saving therapies for WD, there is much controversy surrounding the optimal treatments of patients in the various stages of the disease. Specifically, the relative roles of penicillamine, trientene, and tetrathiomolybdate in the initial treatment of the symptomatic patient with WD remain to be defined. Zinc monotherapy for maintenance treatment and in the treatment of asymptomatic patients with WD is still controversial. It is also unclear whether neurologic status alone is an indication for liver transplantation in WD. This paper reviews the pathogenesis, genetics, clinical presentation, and diagnosis, with a special emphasis on the treatment controversies that arise in the care of the WD patient.
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Wilson Disease
Menkes Disease
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