We are analyzing https://link.springer.com/article/10.1007/s11745-004-1233-3.

Title:
Isoprenoids: Remarkable diversity of form and function | Lipids
Description:
The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In this review we focus on C-10 mono-, C-15 sesqui-, and C-20 diterpenes. Evidence for interconversion between the pathway intermediates farnesyl pyrophosphate and geranylgeranly pyrophosphate and their respective metabolites is examined. The diverse functions of these molecules are discussed in detail, including their ability to regulate expression of the β-HMG-CoA reductase and Ras-related proteins. Additional topics include the mechanisms underlying the apoptotic effects of select isoprenoids, antiulcer activities, and the disposition and degradation of isoprenoids in the environment. Finally, the significance of pharmacological manipulation of the isoprenoid pathway and clinical correlations are discussed.
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Keywords {🔍}

google, scholar, cas, pubmed, article, chem, biol, biochem, res, biosynthesis, reductase, farnesol, cells, kinase, pathway, isoprenoid, mevalonate, cancer, biophys, pyrophosphate, inhibition, cell, farnesyl, protein, sci, rat, microbiol, acid, nat, isoprenoids, effects, activity, apoptosis, commun, diphosphate, formation, geranylgeraniol, liver, proc, usa, lett, alcohol, inhibitor, human, hohl, degradation, synthase, geranylgeranylacetone, mevalonic, acad,

Topics {✒️}

long-chain betulaprenol-type polyprenols 1-deoxy-d-xylulose 5-phosphate precursor month download article/chapter rat-liver 3-hydroxy-3-methylglutaryl-coenzyme 3-hydroxy-3-methylglutaryl-coa reductase gene α-farnesene induce symptoms high-performance liquid chromatography probing sponge-derived terpenoids pkc-dependent signal transduction transcription factor nf-κb microtubule-stabilizing protein tau microsomal 3-hydroxy-3-methylglutary-coenzyme glyceraldehyde 3-phosphate/pyruvate routes farnesol-derived dicarboxylic acids transforming growth factor-α 3-hydroxy-3-methylglutaryl-coa reductase x-irradiated cholesterol-fed β-hmg-coa reductase nuclear receptor fxr/bar glyceraldehyde 3-phosphate/pyruvate pathway farnesol-induced cell death γ-aminobutyric acid receptors death receptor-independent activation chain-length-specific prenyltransferase hmg-coa reductase gene enzyme-geranylgeranyl pyrophosphate complex uncoupling farnesol-induced apoptosis prevent post-translational prenylation hmg-coa reductase activity geranylgeranoic acid-induced apoptosis hmg-coa reductase degradation potent anti-hiv agents hmg-coa reductase inhibitors full article pdf juvenile hormone-mediated regulation mevalonic acid-dependent degradation anti-tumor promoting diterpenes heat shock protein-70 heat-shock protein 72 experimentally induced gastric article lipids sarah mevalonate kinase-deficient patients ras-related protein expression 3-hydroxy-3-methylglutaryl coenzyme 3-hydroxy-3-methylglutaryl-coenzyme privacy choices/manage cookies gtp-binding proteins pyruvate/glyceraldehyde 3-phosphate reactive oxygen species 3-hydroxy-3-methylglutary-coenzyme

Questions {❓}

(1985) Mevalonic Aciduria: An Inborn Error of Cholesterol Biosynthesis?

Schema {🗺️}

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