We are analyzing https://link.springer.com/article/10.1007/s11684-020-0754-0.

Title:
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection | Frontiers of Medicine
Description:
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. To construct a risk map of different human organs, we analyzed the single-cell RNA sequencing (scRNA-seq) datasets derived from major human physiological systems, including the respiratory, cardiovascular, digestive, and urinary systems. Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells), which are vulnerable to 2019-nCoV infection. Based on the findings, we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection. This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Non-Profit & Charity

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

article, pubmed, google, scholar, human, cas, singlecell, chen, ncov, cells, ace, zou, han, kidney, central, shanghai, data, infection, coronavirus, zhang, analysis, research, risk, organs, access, cell, liu, authors, privacy, cookies, expression, open, hao, china, material, license, content, information, publish, search, receptor, download, jie, zeguang, angiotensin, lung, systems, heart, wang, yang,

Topics {✒️}

int/news-room/detail/30-01-2020-statement single-cell rna sequencing angiotensin-converting enzyme-related carboxypeptidase single-cell transcriptomic analysis visualizing single-cell data single-cell transcriptomic map scrna-seq data analyses proximal tubule cells brush-border membrane explains high-level local universities article download pdf single-cell analysis oliveira-dos-santos aj single-cell transcriptomics sars-cov zeguang han declare scrna-seq assessment esophagus epithelial cells early gastric cancer disease lesions identifies privacy choices/manage cookies innovative research team angiotensin-converting enzyme 2 angiotensin converting enzyme invades human cells nasal epithelial cultures pathogenic cellular module understanding sars pathogenesis china national science main target cells jie hao technology major project esophagus tissue stability bladder urothelial cells zeguang han scrna-seq author information authors european economic area probable bat origin gonzalez-gonzalez fj anti-tnf therapy diverse inflammatory response hartnup disorder allele obtain permission directly full access conditions privacy policy international health regulations international-health-regulations mcquattie-pimentel ac creative commons license

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
         description:It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. To construct a risk map of different human organs, we analyzed the single-cell RNA sequencing (scRNA-seq) datasets derived from major human physiological systems, including the respiratory, cardiovascular, digestive, and urinary systems. Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells), which are vulnerable to 2019-nCoV infection. Based on the findings, we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection. This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection.
         datePublished:2020-03-12T00:00:00Z
         dateModified:2020-03-12T00:00:00Z
         pageStart:185
         pageEnd:192
         license:https://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s11684-020-0754-0
         keywords:
            2019-nCoV
            ACE2
            single-cell RNA-seq
            Medicine/Public Health
            general
         image:
         isPartOf:
            name:Frontiers of Medicine
            issn:
               2095-0225
               2095-0217
            volumeNumber:14
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Higher Education Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Xin Zou
               affiliation:
                     name:Shanghai Jiao Tong University
                     address:
                        name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ke Chen
               affiliation:
                     name:Shanghai Jiao Tong University
                     address:
                        name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jiawei Zou
               affiliation:
                     name:Shanghai Jiao Tong University
                     address:
                        name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peiyi Han
               affiliation:
                     name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
                     address:
                        name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jie Hao
               affiliation:
                     name:Shanghai Jiao Tong University
                     address:
                        name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Zeguang Han
               affiliation:
                     name:Shanghai Jiao Tong University
                     address:
                        name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
      description:It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. To construct a risk map of different human organs, we analyzed the single-cell RNA sequencing (scRNA-seq) datasets derived from major human physiological systems, including the respiratory, cardiovascular, digestive, and urinary systems. Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells), which are vulnerable to 2019-nCoV infection. Based on the findings, we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection. This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection.
      datePublished:2020-03-12T00:00:00Z
      dateModified:2020-03-12T00:00:00Z
      pageStart:185
      pageEnd:192
      license:https://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s11684-020-0754-0
      keywords:
         2019-nCoV
         ACE2
         single-cell RNA-seq
         Medicine/Public Health
         general
      image:
      isPartOf:
         name:Frontiers of Medicine
         issn:
            2095-0225
            2095-0217
         volumeNumber:14
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Higher Education Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Xin Zou
            affiliation:
                  name:Shanghai Jiao Tong University
                  address:
                     name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ke Chen
            affiliation:
                  name:Shanghai Jiao Tong University
                  address:
                     name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jiawei Zou
            affiliation:
                  name:Shanghai Jiao Tong University
                  address:
                     name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peiyi Han
            affiliation:
                  name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
                  address:
                     name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jie Hao
            affiliation:
                  name:Shanghai Jiao Tong University
                  address:
                     name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Zeguang Han
            affiliation:
                  name:Shanghai Jiao Tong University
                  address:
                     name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Frontiers of Medicine
      issn:
         2095-0225
         2095-0217
      volumeNumber:14
Organization:
      name:Higher Education Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Shanghai Jiao Tong University
      address:
         name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
         type:PostalAddress
      name:Shanghai Jiao Tong University
      address:
         name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
         type:PostalAddress
      name:Shanghai Jiao Tong University
      address:
         name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
         type:PostalAddress
      name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      address:
         name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
         type:PostalAddress
      name:Shanghai Jiao Tong University
      address:
         name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
         type:PostalAddress
      name:Shanghai Jiao Tong University
      address:
         name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Xin Zou
      affiliation:
            name:Shanghai Jiao Tong University
            address:
               name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Ke Chen
      affiliation:
            name:Shanghai Jiao Tong University
            address:
               name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Jiawei Zou
      affiliation:
            name:Shanghai Jiao Tong University
            address:
               name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Peiyi Han
      affiliation:
            name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
            address:
               name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Jie Hao
      affiliation:
            name:Shanghai Jiao Tong University
            address:
               name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zeguang Han
      affiliation:
            name:Shanghai Jiao Tong University
            address:
               name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
      name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
      name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
      name:Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
      name:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China

External Links {🔗}(99)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.75s.

LINK . SPRINGER . COM {}