We are analyzing https://link.springer.com/article/10.1007/s11605-003-0037-5.

Title:
Induction of MIC-1/growth differentiation factor-15 following bile duct injury | Journal of Gastrointestinal Surgery
Description:
Macrophage inflammatory peptide-1 (MIC-1)/growth/differentiation factor-15 (GDF-15) is a divergent member of the transforming growth factor-β superfamily cloned by others and us. MIC-1/GDF-15 is expressed in the liver, breast, and colon. Studies have demonstrated a growth-inhibiting effect of MIC-1/GDF-15 on colon and breast cancer cell lines in vitro and on tumor growth in vivo. We previously reported that MIC-1 expression is rapidly induced after a wide variety of murine acute and chronic liver injuries including aniline dye administration. I hypothesized, therefore, that MIC-1/GDF-15 may be a mediator of biliary tract injury and could play a role in regulation of bile duct proliferation. C57BL/6 mice underwent surgical ligation of the common bile duct. Northern blot analysis revealed a time-dependent induction of MIC-1/GDF-15 mRNA in the liver. In situ hybridization of liver sections for MIC-1/GDF-15 expression after bile duct ligation demonstrated a zone 1 or periportal expression pattern, consistent with expression of MIC-1 in periductular hepatocytes. Northern blot analysis of liver mRNA from patients with sclerosing cholangitis or cirrhosis also demonstrated enhanced expression of MIC-1/GDF-15. MIC-1/GDF-15 is expressed after bile duct injury in mice and humans. Taken together with the previously demonstrated growth inhibitory effects of MIC-1/GDF-15 on normal and transformed cells, MIC-1/ GDF-15 may play a role in regulation of bile duct proliferation and biliary tumor formation.
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Keywords {🔍}

article, google, scholar, cas, pubmed, growth, bile, expression, duct, liver, koniaris, gene, factor, micgdf, tgfbeta, member, superfamily, human, journal, induction, injury, transforming, access, cytokine, privacy, cookies, content, tumor, mic, biliary, mice, inhibitory, baek, publish, search, surgery, macrophage, expressed, demonstrated, tract, cells, characterization, biol, protein, eling, nonsteroidal, antiinflammatory, analysis, data, information,

Topics {✒️}

biliary tract injury nonsteroidal anti-inflammatory drugs month download article/chapter cholestatic liver disease antitumorigenic nsaid-activated gene biliary tumor formation mic-1/growth differentiation factor-15 nested case-control study tgf-beta signaling pathway bile duct injury common bile duct bile duct proliferation /growth/differentiation factor-15 growth-differentiation factor 15 macrophage inhibitory cytokine macrophage inhibitory cytokine-1 tgf-beta family nsaid-activated gene tgf-beta superfamily growth-inhibiting effect full article pdf tgf-beta pathway privacy choices/manage cookies northern blot analysis gene expression regulated p53 target gene human cdna encoding european economic area hsiao ec partial hepa-tectomy systemically administered myostatin alan livingstone chair time-dependent induction tumor suppressor activity baek sj demonstrated enhanced expression glioblastoma cells independently conditions privacy policy periportal expression pattern inhibin-betac expression article koniaris article journal check access instant access accepting optional cookies november 2003 volume 7 related subjects injured rat brain p53-dependent mechanism tgf-beta

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         description:Macrophage inflammatory peptide-1 (MIC-1)/growth/differentiation factor-15 (GDF-15) is a divergent member of the transforming growth factor-β superfamily cloned by others and us. MIC-1/GDF-15 is expressed in the liver, breast, and colon. Studies have demonstrated a growth-inhibiting effect of MIC-1/GDF-15 on colon and breast cancer cell lines in vitro and on tumor growth in vivo. We previously reported that MIC-1 expression is rapidly induced after a wide variety of murine acute and chronic liver injuries including aniline dye administration. I hypothesized, therefore, that MIC-1/GDF-15 may be a mediator of biliary tract injury and could play a role in regulation of bile duct proliferation. C57BL/6 mice underwent surgical ligation of the common bile duct. Northern blot analysis revealed a time-dependent induction of MIC-1/GDF-15 mRNA in the liver. In situ hybridization of liver sections for MIC-1/GDF-15 expression after bile duct ligation demonstrated a zone 1 or periportal expression pattern, consistent with expression of MIC-1 in periductular hepatocytes. Northern blot analysis of liver mRNA from patients with sclerosing cholangitis or cirrhosis also demonstrated enhanced expression of MIC-1/GDF-15. MIC-1/GDF-15 is expressed after bile duct injury in mice and humans. Taken together with the previously demonstrated growth inhibitory effects of MIC-1/GDF-15 on normal and transformed cells, MIC-1/ GDF-15 may play a role in regulation of bile duct proliferation and biliary tumor formation.
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