We are analyzing https://link.springer.com/article/10.1007/s11427-016-0348-7.

Title:
Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling | Science China Life Sciences
Description:
Cellular metabolism has been shown to regulate differentiation and function of immune cells. Tumor associated immune cells undergo phenotypic and functional alterations due to the change of cellular metabolism in tumor microenvironments. NKT cells are good candidates for immunotherapies against tumors and have been used in several clinical trials. However, the influences of tumor microenvironments on NKT cell functions remain unclear. In our studies, lactic acid in tumor microenvironments inhibited IFNγ and IL4 productions from NKT cells, and more profound influence on IFNγ was observed. By adjusting the pH of culture medium we further showed that, dysfunction of NKT cells could simply be induced by low extracellular pH. Moreover, low extracellular pH inhibited NKT cell functions by inhibiting mammalian target of rapamycin (mTOR) signaling and nuclear translocation of promyelocytic leukemia zinc-finger (PLZF). Together, our results suggest that tumor acidic microenvironments could interfere with NKT cell functions through metabolic controls.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, article, google, scholar, cells, cas, cell, immunol, central, nkt, tumor, cancer, immune, function, china, acid, access, bai, metabolism, metabolic, pearce, lactic, mtor, open, research, science, microenvironments, privacy, cookies, functions, natural, savage, bendelac, liu, immunity, effector, van, front, clin, content, information, publish, search, life, sciences, signaling, download, xie, zhu, microenvironment,

Topics {✒️}

shasha zhu & li bai promyelocytic leukemia zinc-finger inkt cell-based immunotherapy article download pdf a-galactosylceramide variants ideal anti-tumor immunotherapeutic china life sci phase i-ii study anti-tumor immune response cell memory development low extracellular ph lactic acid delays fundamental research funds open access nkt cell functions life sciences molecular cell science nkt cell lineage van der windt privacy choices/manage cookies related subjects cd1d-pbs57 tetramer intratumoral dendritic cells van der vliet cell signaling network cas center invariant nk metabolism shapes immunity article xie lactic acid van den eertwegh li bai main content log central universities search search full access european economic area functional alterations due treg/th17 axis mitochondrial respiratory capacity albert einstein college inhibiting mammalian target nk cells conditions privacy policy hefei national laboratory creative commons license intercellular metabolic interplay distinct apcs explain cellular metabolism tumor acidic microenvironments

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling
         description:Cellular metabolism has been shown to regulate differentiation and function of immune cells. Tumor associated immune cells undergo phenotypic and functional alterations due to the change of cellular metabolism in tumor microenvironments. NKT cells are good candidates for immunotherapies against tumors and have been used in several clinical trials. However, the influences of tumor microenvironments on NKT cell functions remain unclear. In our studies, lactic acid in tumor microenvironments inhibited IFNγ and IL4 productions from NKT cells, and more profound influence on IFNγ was observed. By adjusting the pH of culture medium we further showed that, dysfunction of NKT cells could simply be induced by low extracellular pH. Moreover, low extracellular pH inhibited NKT cell functions by inhibiting mammalian target of rapamycin (mTOR) signaling and nuclear translocation of promyelocytic leukemia zinc-finger (PLZF). Together, our results suggest that tumor acidic microenvironments could interfere with NKT cell functions through metabolic controls.
         datePublished:2016-12-05T00:00:00Z
         dateModified:2016-12-05T00:00:00Z
         pageStart:1290
         pageEnd:1296
         license:https://creativecommons.org/licenses/by/4.0
         sameAs:https://doi.org/10.1007/s11427-016-0348-7
         keywords:
            lactic acid
            NKT cell
            IFNγ
            mTOR
            PLZF
            Life Sciences
            general
         image:
         isPartOf:
            name:Science China Life Sciences
            issn:
               1869-1889
               1674-7305
            volumeNumber:59
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Science China Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Di Xie
               affiliation:
                     name:University of Science and Technology of China
                     address:
                        name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
                        type:PostalAddress
                     type:Organization
                     name:Hefei National Laboratory for Physical Sciences at Microscale
                     address:
                        name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shasha Zhu
               affiliation:
                     name:University of Science and Technology of China
                     address:
                        name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
                        type:PostalAddress
                     type:Organization
                     name:Hefei National Laboratory for Physical Sciences at Microscale
                     address:
                        name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Li Bai
               affiliation:
                     name:University of Science and Technology of China
                     address:
                        name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
                        type:PostalAddress
                     type:Organization
                     name:Hefei National Laboratory for Physical Sciences at Microscale
                     address:
                        name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling
      description:Cellular metabolism has been shown to regulate differentiation and function of immune cells. Tumor associated immune cells undergo phenotypic and functional alterations due to the change of cellular metabolism in tumor microenvironments. NKT cells are good candidates for immunotherapies against tumors and have been used in several clinical trials. However, the influences of tumor microenvironments on NKT cell functions remain unclear. In our studies, lactic acid in tumor microenvironments inhibited IFNγ and IL4 productions from NKT cells, and more profound influence on IFNγ was observed. By adjusting the pH of culture medium we further showed that, dysfunction of NKT cells could simply be induced by low extracellular pH. Moreover, low extracellular pH inhibited NKT cell functions by inhibiting mammalian target of rapamycin (mTOR) signaling and nuclear translocation of promyelocytic leukemia zinc-finger (PLZF). Together, our results suggest that tumor acidic microenvironments could interfere with NKT cell functions through metabolic controls.
      datePublished:2016-12-05T00:00:00Z
      dateModified:2016-12-05T00:00:00Z
      pageStart:1290
      pageEnd:1296
      license:https://creativecommons.org/licenses/by/4.0
      sameAs:https://doi.org/10.1007/s11427-016-0348-7
      keywords:
         lactic acid
         NKT cell
         IFNγ
         mTOR
         PLZF
         Life Sciences
         general
      image:
      isPartOf:
         name:Science China Life Sciences
         issn:
            1869-1889
            1674-7305
         volumeNumber:59
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Science China Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Di Xie
            affiliation:
                  name:University of Science and Technology of China
                  address:
                     name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
                     type:PostalAddress
                  type:Organization
                  name:Hefei National Laboratory for Physical Sciences at Microscale
                  address:
                     name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shasha Zhu
            affiliation:
                  name:University of Science and Technology of China
                  address:
                     name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
                     type:PostalAddress
                  type:Organization
                  name:Hefei National Laboratory for Physical Sciences at Microscale
                  address:
                     name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li Bai
            affiliation:
                  name:University of Science and Technology of China
                  address:
                     name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
                     type:PostalAddress
                  type:Organization
                  name:Hefei National Laboratory for Physical Sciences at Microscale
                  address:
                     name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Science China Life Sciences
      issn:
         1869-1889
         1674-7305
      volumeNumber:59
Organization:
      name:Science China Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Science and Technology of China
      address:
         name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
         type:PostalAddress
      name:Hefei National Laboratory for Physical Sciences at Microscale
      address:
         name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
         type:PostalAddress
      name:University of Science and Technology of China
      address:
         name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
         type:PostalAddress
      name:Hefei National Laboratory for Physical Sciences at Microscale
      address:
         name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
         type:PostalAddress
      name:University of Science and Technology of China
      address:
         name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
         type:PostalAddress
      name:Hefei National Laboratory for Physical Sciences at Microscale
      address:
         name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Di Xie
      affiliation:
            name:University of Science and Technology of China
            address:
               name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
               type:PostalAddress
            type:Organization
            name:Hefei National Laboratory for Physical Sciences at Microscale
            address:
               name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
               type:PostalAddress
            type:Organization
      name:Shasha Zhu
      affiliation:
            name:University of Science and Technology of China
            address:
               name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
               type:PostalAddress
            type:Organization
            name:Hefei National Laboratory for Physical Sciences at Microscale
            address:
               name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
               type:PostalAddress
            type:Organization
      name:Li Bai
      affiliation:
            name:University of Science and Technology of China
            address:
               name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
               type:PostalAddress
            type:Organization
            name:Hefei National Laboratory for Physical Sciences at Microscale
            address:
               name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
      name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
      name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
      name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China
      name:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China
      name:Innovation Center for Cell Signaling Network, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China

External Links {🔗}(159)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.1s.

LINK . SPRINGER . COM {}