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Title:
Epigenetic changes associated with oocyte aging | Science China Life Sciences
Description:
It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age. Furthermore, we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.
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Keywords {π}
article, pubmed, google, scholar, aging, oocyte, methylation, oocytes, histone, biol, dna, mouse, epigenetic, reprod, dev, central, development, cell, hum, wang, access, postovulatory, maternal, expression, open, liang, sun, acetylation, mammalian, mol, reproductive, age, fertil, preimplantation, imprinting, genet, modifications, cycle, privacy, cookies, schatten, chromosome, regulation, mice, genes, methyltransferase, embryo, content, information, publish,
Topics {βοΈ}
maturation/m-phase promoting factor china life sci oocyte growth-dependent progression article download pdf sex-specific methylation marked chromosome segregation error sequential adp-ribosylation pattern positive-acting histone modifications advanced maternal age icsi-derived embryo development open access germinal vesicle stage epigenetic modification privacy choices/manage cookies de novo methylation postovulatory oocyte aging van der hoeven dna methylation mechanisms dna methylation levels abnormal dna methylation dna methylation imprints epigenetic memory oocyte aging process bmc dev biol underlying epigenetic mechanisms meiotic spindle organization active dna demethylation dna methyltransferase expression cancer dna hypermethylation porcine oocyte aging full access paternal methylation imprints mammalian oocyte maturation mouse germ line main content log human oocyte maturation related mrna expression ovarian follicle aging pyruvate prevents aging mouse germ cells poor oocyte quality genomic methylation patterns article liang european economic area compromised genetic integrity safeguarding parental identity adult differentiated colon search search related subjects mammalian histone deacetylase
Questions {β}
- Why is chromosome segregation error in oocytes increased with maternal aging?
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WebPage:
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headline:Epigenetic changes associated with oocyte aging
description:It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age. Furthermore, we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.
datePublished:2012-08-30T00:00:00Z
dateModified:2012-08-30T00:00:00Z
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license:https://creativecommons.org/licenses/by/2.0
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fertility
advanced maternal age
postovulatory oocyte aging
DNA methylation
histone modification
Life Sciences
general
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name:Department of Animal Sciences, Chungbuk National University, Cheongju, Republic of Korea
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headline:Epigenetic changes associated with oocyte aging
description:It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age. Furthermore, we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.
datePublished:2012-08-30T00:00:00Z
dateModified:2012-08-30T00:00:00Z
pageStart:670
pageEnd:676
license:https://creativecommons.org/licenses/by/2.0
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fertility
advanced maternal age
postovulatory oocyte aging
DNA methylation
histone modification
Life Sciences
general
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name:State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
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