We are analyzing https://link.springer.com/article/10.1007/s11427-011-4249-8.

Title:
MicroRNAs in neural cell development and brain diseases | Science China Life Sciences
Description:
MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation and/or promoting mRNA degradation. Importantly, biogenesis of microRNAs displays specific temporal and spatial profiles in distinct cell and tissue types and hence affects a broad spectrum of biological functions in normal cell growth and tumor development. Recent discoveries have revealed sophisticated mechanisms that control microRNA production and homeostasis in response to developmental and extracellular signals. Moreover, a link between dysregulation of microRNAs and human brain disorders has become increasingly evident. In this review, we focus on recent advances in understanding the regulation of microRNA biogenesis and function in neuronal and glial development in the mammalian brain, and dysregulation of the microRNA pathway in neurodevelopmental and neurodegenerative diseases.
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Keywords {🔍}

pubmed, google, scholar, cas, central, microrna, cell, micrornas, expression, brain, development, regulation, human, sci, glioblastoma, dicer, mouse, neurosci, cells, biol, usa, res, cancer, glioma, mol, proc, natl, acad, article, protein, zhang, neural, tumor, differentiation, medulloblastoma, feng, neuronal, disease, nat, targeting, access, biogenesis, growth, mirna, precursor, essential, open, neurogenesis, dev, kim,

Topics {✒️}

increased bace1/beta-secretase expression altered short-term plasticity nervous-system-specific microrna-124a microrna cluster mir-29a/b-1 human brain disorders pten-regulating microrna mir-26a cell-autonomous neuronal dysfunction china life sci oligodendroglial cell number sonic hedgehog-driven medulloblastomas yue feng dendritic spine morphogenesis potentially modulate alzheimer’s key tumor-suppressive pathways article download pdf mir-34a confers chemosensitivity mirna-mediated gene silencing small rnas neurodegenerative diseases repress c-myc expression glioma stem cells microrna-mediated translational repression microrna binding sites coding regions reveals spatial profiles excitatory synaptic transmission microrna-126 regulates hoxa9 sonic hedgehog pathway human glioma cells human glioma growth depalmitoylation enzyme apt1 neuronal activity inhibiting protein translation protein phosphate ptpmu mental retardation protein calpain-dependent manner article feng adult mouse brain 22q11-deletion mouse model creb-induced microrna privacy choices/manage cookies mir-125b expression affects brain cell proliferation adult mouse forebrain tissue-specific micrornas human cells subjected neural cell development brain tumor biology microrna hierarchy system steady-state level

Schema {🗺️}

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         headline:MicroRNAs in neural cell development and brain diseases
         description:MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation and/or promoting mRNA degradation. Importantly, biogenesis of microRNAs displays specific temporal and spatial profiles in distinct cell and tissue types and hence affects a broad spectrum of biological functions in normal cell growth and tumor development. Recent discoveries have revealed sophisticated mechanisms that control microRNA production and homeostasis in response to developmental and extracellular signals. Moreover, a link between dysregulation of microRNAs and human brain disorders has become increasingly evident. In this review, we focus on recent advances in understanding the regulation of microRNA biogenesis and function in neuronal and glial development in the mammalian brain, and dysregulation of the microRNA pathway in neurodevelopmental and neurodegenerative diseases.
         datePublished:2012-01-07T00:00:00Z
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            synaptic plasticity
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            brain tumor
            neurodegenerative disorders
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      description:MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation and/or promoting mRNA degradation. Importantly, biogenesis of microRNAs displays specific temporal and spatial profiles in distinct cell and tissue types and hence affects a broad spectrum of biological functions in normal cell growth and tumor development. Recent discoveries have revealed sophisticated mechanisms that control microRNA production and homeostasis in response to developmental and extracellular signals. Moreover, a link between dysregulation of microRNAs and human brain disorders has become increasingly evident. In this review, we focus on recent advances in understanding the regulation of microRNA biogenesis and function in neuronal and glial development in the mammalian brain, and dysregulation of the microRNA pathway in neurodevelopmental and neurodegenerative diseases.
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         neuronal development
         synaptic plasticity
         oligodendroglial differentiation
         brain tumor
         neurodegenerative disorders
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         general
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