We are analyzing https://link.springer.com/article/10.1007/s11427-011-4213-7.

Title:
Identification and functional annotation of novel microRNAs in the proximal sciatic nerve after sciatic nerve transection | Science China Life Sciences
Description:
The peripheral nervous system is able to regenerate after injury, and regeneration is associated with the expression of many genes and proteins. MicroRNAs are evolutionarily conserved, small, non-coding RNA molecules that regulate gene expression at the level of translation. In this paper, we focus on the identification and functional annotation of novel microRNAs in the proximal sciatic nerve after rat sciatic nerve transection. Using Solexa sequencing, computational analysis, and quantitative reverse transcription PCR verification, we identified 98 novel microRNAs expressed on days 0, 1, 4, 7, and 14 after nerve transection. Furthermore, we predicted the target genes of these microRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the known time-frame of peripheral nerve injury and repair. Our data provide an important resource for further study of the role and regulation of microRNAs in peripheral nerve injury and regeneration.
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Keywords {🔍}

pubmed, article, google, scholar, cas, micrornas, nerve, central, sciatic, expression, injury, microrna, identification, access, wang, peripheral, cell, nature, open, rna, res, sci, privacy, cookies, data, functional, transection, zhang, regeneration, gene, protein, bioinformatics, content, analysis, information, publish, research, search, science, china, proximal, download, rat, solexa, rnas, spinal, cord, nucleic, acids, function,

Topics {✒️}

zhanhu zhang & xiaosong gu article download pdf china life sci stem-loop rt-pcr cell-type-specific signatures peripheral nervous system proximal sciatic nerve sciatic nerve transection peripheral nerve injury sciatic nerve resection crushed sciatic nerve privacy choices/manage cookies related subjects open access rat spinal cord article li jones-rhoades sciatic nerve repair spinal cord injury regulate gene expression homeobox gene expression nat rev neurosci article cite main content log xiaosong gu pseudo microrna precursors microrna-directed cleavage coding rnas coding rna molecules european economic area adrenal medullary grafting altered microrna expression nucleic acids res genomic pseudo hairpins intrinsic folding measures curr opin neurobiol search search nmda receptor expression altered neuronatin expression microrna identification based full access conditions privacy policy cerna network identification real-time quantification conserved seed pairing systemic functional enrichment bombyx mori identified nerve transection accepting optional cookies article

Questions {❓}

MicroRNA function: multiple mechanisms for a tiny RNA?

Schema {🗺️}

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         description:The peripheral nervous system is able to regenerate after injury, and regeneration is associated with the expression of many genes and proteins. MicroRNAs are evolutionarily conserved, small, non-coding RNA molecules that regulate gene expression at the level of translation. In this paper, we focus on the identification and functional annotation of novel microRNAs in the proximal sciatic nerve after rat sciatic nerve transection. Using Solexa sequencing, computational analysis, and quantitative reverse transcription PCR verification, we identified 98 novel microRNAs expressed on days 0, 1, 4, 7, and 14 after nerve transection. Furthermore, we predicted the target genes of these microRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the known time-frame of peripheral nerve injury and repair. Our data provide an important resource for further study of the role and regulation of microRNAs in peripheral nerve injury and regeneration.
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