We are analyzing https://link.springer.com/article/10.1007/s11427-011-4149-y.

Title:
The miRNA expression profile of the uveal melanoma | Science China Life Sciences
Description:
The miRNA expression profile was initially established to investigate its corresponding function in human uveal melanoma. The miRNA expression profile in human uveal melanoma was analyzed by a micro chip technique. The hsa-miRNA expression between four uveal melanomas and four normal uveal tissues was compared. Based on the bioinformatic approach, chip data was analyzed to select out differentially expressed candidate hsa-miRNAs. Real-time quantitative PCR (RT-PCR) was used to confirm the candidate hsa-miRNAs expression in all samples. The results of miRNA microarray chips that matched with RT-PCR were considered as the miRNA expression which was significantly different between normal tissue and uveal melanomas. In four uveal melanomas, expressions of miRNA-20a, miRNA-106a, miRNA-17, miRNA-21, and miRNA-34a were significantly up-regulated, while miRNA-145 and miRNA-204 expression were significantly down-regulated. We used miRNA microarray analysis as a fast, efficient technology to study biological information. The differentially expressed miRNAs may be involved in uveal melanoma pathogenesis, and may help promote the diagnosis and treatment for uveal melanoma.
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Keywords {🔍}

article, uveal, melanoma, pubmed, google, scholar, expression, mirna, cas, access, nature, open, microrna, micrornas, cancer, privacy, cookies, information, science, china, profile, wei, human, microarray, mirnaa, content, data, publish, research, search, download, yang, wenbin, res, mol, sci, beijing, analysis, journal, life, published, march, chenghsun, melanomas, differentially, expressed, significantly, discover, gene, central,

Topics {✒️}

circulating cell-free rna candidate hsa-mirnas expression multiplexed microarray profiling china life sci mirna microarray analysis article download pdf differentially expressed mirnas small rnas human uveal melanoma real-time quantitative pcr article yang uveal melanoma pathogenesis uveal melanoma identified wenbin wei open access mirna microarray chips privacy choices/manage cookies mir-181b-5p hsa-mirna expression microrna expression signature mir-454-3p expressions mol cancer res uveal melanoma mammalian microrna expression normal uveal tissues potential human oncogene real-time pcr study biological information mirna expression profiles int ophthalmol clin beijing tongren hospital full access mirna expression profile european economic area related subjects clin chim acta van holst pellekaan capital medical university conditions privacy policy micro-rnas acute lymphocytic leukemia med biol res search search usage analysis article cite accepting optional cookies micro chip technique mir-155-5p mol cancer melanoma res

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         headline:The miRNA expression profile of the uveal melanoma
         description:The miRNA expression profile was initially established to investigate its corresponding function in human uveal melanoma. The miRNA expression profile in human uveal melanoma was analyzed by a micro chip technique. The hsa-miRNA expression between four uveal melanomas and four normal uveal tissues was compared. Based on the bioinformatic approach, chip data was analyzed to select out differentially expressed candidate hsa-miRNAs. Real-time quantitative PCR (RT-PCR) was used to confirm the candidate hsa-miRNAs expression in all samples. The results of miRNA microarray chips that matched with RT-PCR were considered as the miRNA expression which was significantly different between normal tissue and uveal melanomas. In four uveal melanomas, expressions of miRNA-20a, miRNA-106a, miRNA-17, miRNA-21, and miRNA-34a were significantly up-regulated, while miRNA-145 and miRNA-204 expression were significantly down-regulated. We used miRNA microarray analysis as a fast, efficient technology to study biological information. The differentially expressed miRNAs may be involved in uveal melanoma pathogenesis, and may help promote the diagnosis and treatment for uveal melanoma.
         datePublished:2011-03-14T00:00:00Z
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      headline:The miRNA expression profile of the uveal melanoma
      description:The miRNA expression profile was initially established to investigate its corresponding function in human uveal melanoma. The miRNA expression profile in human uveal melanoma was analyzed by a micro chip technique. The hsa-miRNA expression between four uveal melanomas and four normal uveal tissues was compared. Based on the bioinformatic approach, chip data was analyzed to select out differentially expressed candidate hsa-miRNAs. Real-time quantitative PCR (RT-PCR) was used to confirm the candidate hsa-miRNAs expression in all samples. The results of miRNA microarray chips that matched with RT-PCR were considered as the miRNA expression which was significantly different between normal tissue and uveal melanomas. In four uveal melanomas, expressions of miRNA-20a, miRNA-106a, miRNA-17, miRNA-21, and miRNA-34a were significantly up-regulated, while miRNA-145 and miRNA-204 expression were significantly down-regulated. We used miRNA microarray analysis as a fast, efficient technology to study biological information. The differentially expressed miRNAs may be involved in uveal melanoma pathogenesis, and may help promote the diagnosis and treatment for uveal melanoma.
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         miRNA
         microRNA microarray
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