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Title:
microRNA-181b targets MLK2 in HL-60 cells | Science China Life Sciences
Description:
microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
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Keywords {🔍}
pubmed, article, google, scholar, cas, myeloid, acute, leukemia, kinase, biol, cancer, chem, microrna, cell, central, mapk, mlk, cells, chen, micrornas, apoptosis, aml, expression, jbcm, china, proliferation, activation, protein, harbin, privacy, cookies, content, research, access, blood, res, human, signaling, mixed, lineage, information, publish, search, science, mirb, nature, kim, sci, cjun, nterminal,
Topics {✒️}
c-jun n-terminal kinase mitogen-activated kinase pathways microrna-181b targets mlk2 month download article/chapter c-terminal domain china life sci acute myeloid leukaemia cap-binding complex eif4f stem-loop rt-pcr mlk2-induced apoptosis mlk2-mediated signaling cascades ifn -“gamma”-mediated inhibition acute myeloid leukemia hsa-mir-181b function chronic lymphocytic leukemia dc%2bd2mxot1chsa%3d%3d dc%2bd1cxhs1wmtw%3d%3d dc%2bd2mxlsfyhsg%3d%3d yan mi activated jnk phosphorylates full article pdf hsa-mir-181b showed mir-181b mir-181b contributed mir-181b plays privacy choices/manage cookies long noncoding rnas antiapoptotic gene products internal tandem duplication p38/rk pathways microrna targets article chen human myeloid cells coding micrornas hsa mapk p38 alpha harbin medical university hsa-mir-181a dc%2bd3mxntfwgsbg%3d dc%2bd3mxnsveht7c%3d dc%2bd2mxit1yqsrk%3d dc%2bd2cxhtvals7o%3d dc%2bd1mxjtf2rsl0%3d dc%2bd1cxjvvamtby%3d dc%2bd1cxlt1gnsr0%3d dc%2bd28xntf2mtlc%3d dc%2bd2mxhtvyntbo%3d dc%2bd1cxlsvwgu7k%3d dc%2bd3mxjvfarsro%3d dc%2bd3mxjvfcqtbo%3d dc%2bd3mxks1gju7k%3d
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headline:microRNA-181b targets MLK2 in HL-60 cells
description:microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
datePublished:2010-02-12T00:00:00Z
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proliferation
apoptosis
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description:microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
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