We are analyzing https://link.springer.com/article/10.1007/s11357-017-9970-1.

Title:
Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells | GeroScience
Description:
Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid found in certain herbs, fruits, and vegetables. Apigenin can attenuate inflammation, which is associated with many chronic diseases of aging. Senescent cells—stressed cells that accumulate with age in mammals—display a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. Flavonoids, including apigenin, were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin. Here, we confirm that apigenin suppresses the SASP in three human fibroblast strains induced to senesce by ionizing radiation, constitutive MAPK (mitogen-activated protein kinase) signaling, oncogenic RAS, or replicative exhaustion. Apigenin suppressed the SASP in part by suppressing IL-1α signaling through IRAK1 and IRAK4, p38-MAPK, and NF-κB. Apigenin was particularly potent at suppressing the expression and secretion of CXCL10 (IP10), a newly identified SASP factor. Further, apigenin-mediated suppression of the SASP substantially reduced the aggressive phenotype of human breast cancer cells, as determined by cell proliferation, extracellular matrix invasion, and epithelial-mesenchymal transition. Our results support the idea that apigenin is a promising natural product for reducing the impact of senescent cells on age-related diseases such as cancer.
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Keywords {🔍}

pubmed, article, google, scholar, cas, apigenin, cells, campisi, cell, central, senescenceassociated, senescent, cancer, secretory, flavonoids, phenotype, desprez, sasp, human, fibroblasts, aging, levels, research, inflammation, induced, expression, secretion, suppression, senescence, nature, biol, pdf, privacy, cookies, content, effects, senesce, nfκb, related, cellular, patil, freund, inflammatory, publish, search, geroscience, suppresses, breast, judith, access,

Topics {✒️}

mitogen-activated protein kinase phosphatidylinositol 3-kinase/akt-dependent pathway month download article/chapter nf-κb reporter activation nf-κb activation pathways extracellular matrix invasion il6/il-8 cytokine network epithelial-mesenchymal transition induced cell surface il-1α inactivating nf-kappab proinflammatory nf-kappab senescent cells—stressed cells p53 tumor suppressor recombinant il-1a remi-martin laberge article geroscience aims suppressing il-1α signaling hif-1α protein full article pdf sens research foundation human cellular senescence breast cancer cells cell proliferation privacy choices/manage cookies epithelial-mesenchymal transition matrix-degrading proteases mouse cells dependent dmso-treated ns cells nf-κb selective growth-inhibitory il-1a nf-kb p65 apigenin inhibits release decreasing caspase-3 activation coppé jp structurally related flavonoids age-related pathologies cell-cycle deregulatory cell cycle progression inflammatory cytokine secretion senescent hca2 cells secretory phenotype formation switches immune response cancer cell apoptosis anti-inflammatory activity senescent bj fibroblasts european economic area casaclang versoza gc van deursen jm pereira-smith om

Schema {🗺️}

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