
LINK . SPRINGER . COM {
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Title:
KLRG1βmore than a marker for T cell senescence | GeroScience
Description:
The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role. In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling.
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Keywords {π}
pubmed, google, scholar, cas, article, cell, cells, immunol, receptor, klrg, memory, akbar, pircher, killer, inhibitory, lectinlike, human, exp, effector, senescence, aging, age, access, antigen, med, privacy, cookies, content, research, henson, infection, eur, doi, elderly, function, data, publish, search, marker, differentiation, role, mast, functionassociated, dois, fletcher, doijem, appay, gerontol, influenza, hanke,
Topics {βοΈ}
t-bet transcription factor highly differentiated cd8+cd28-cd27 month download article/chapter t-cell diversity x-linked lymphoproliferative syndrome inhibitory c-type lectin short-lived effector cd8 cellular differentiation cell subset-specific susceptibility highly differentiated cd8+ human cd8+cd45ra+pool full article pdf mouse nk cells natural killer cells memory hiv-specific cd8 article age aims privacy choices/manage cookies cell senescence published killer cell lectin plunkett fj biological research council inhibitory receptor signalling unusual inhibitory receptor accelerated immune senescence virus-activated cd8 goronzy jj receptor g1 binds receptor g1 molecule persistent virus infections human cord blood nk cells human virus-specific cmv-specific cd8+ virus-specific cd8 age-related cd8 european economic area examine evidence highlighting epstein-barr virus defined adult population identifies unique subpopulations cadherin-mediated adhesion kerkhof-garde sr classical cadherin family abramson inositol polyphosphate 5β²-phosphatase article henson mast cell function effector human cd8+ related subjects klrg1 identifies regulatory
Questions {β}
- Pawelec G, Akbar AN, Caruso C, Effros R, Grubeck-Loebenstein B, Wikby A (2004) Is immunosenescence infectious?
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WebPage:
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headline:KLRG1βmore than a marker for T cell senescence
description: The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role. In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling.
datePublished:2009-05-29T00:00:00Z
dateModified:2009-05-29T00:00:00Z
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KLRG1
Inhibitory
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Highly differentiated T cell
Cell Biology
Geriatrics/Gerontology
Molecular Medicine
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headline:KLRG1βmore than a marker for T cell senescence
description: The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role. In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling.
datePublished:2009-05-29T00:00:00Z
dateModified:2009-05-29T00:00:00Z
pageStart:285
pageEnd:291
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KLRG1
Inhibitory
ITIM
Highly differentiated T cell
Cell Biology
Geriatrics/Gerontology
Molecular Medicine
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