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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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We are analyzing https://link.springer.com/article/10.1007/s11307-007-0120-5.

Title:
Noninvasive Real-time Imaging of Tumors and Metastases Using Tumor-targeting Light-emitting Escherichia coli | Molecular Imaging and Biology
Description:
Purpose A number of bacteria types are known to preferentially grow in tumors. We have taken advantage of this phenomenon to target luciferase-expressing Escherichia coli to tumors and metastases in mouse models to image them noninvasively. Methods and Results After intravenous injection of pLux-expressing E. coli (108 CFU), bioluminescence signals from the bacteria were detected exclusively in tumor tissue after 24 hours. The balanced-lethal host–vector system using the gene encoding aspartate β-semialdehyde dehydrogenase (asd) enabled stable maintenance of the pLux in the tumor-targeting E. coli. This phenomenon of selective tumor targeting and proliferation of E. coli was observed in a diverse range of tumors implanted in nude mice. More importantly, E. coli was capable of targeting both primary tumors and metastases, enabling them to be imaged noninvasively in both nude and immunocompetent mice. Conclusions Our results suggest the potential clinical use of this technology for tumor targeting.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

google, scholar, article, pubmed, cas, imaging, coli, cancer, tumor, tumors, bacteria, escherichia, gene, salmonella, korea, tumortargeting, res, national, metastases, kim, proc, natl, acad, sci, department, chonnam, university, gwangju, south, privacy, cookies, content, park, targeting, access, genes, vivo, typhimurium, medical, school, publish, research, search, molecular, lightemitting, min, jae, mouse, system, stable,

Topics {✒️}

noninvasive real-time imaging balanced-lethal host–vector system tumor-targeting bacterial therapy month download article/chapter fundamental biological processes gfp-expressing salmonella typhimurium article molecular imaging joon haeng rhee & hyon escherichia coli k-12 mutant escherichia coli optical imaging tumor-targeting salmonella vivo molecular imaging cancer-targeting bacteria access salmonella vaccine strains jong hee nam hee-seung bom jung-joon min full article pdf tumor-targeting mutant selective tumor targeting tumor-targeted salmonella human prostate cancer suppresses tumor growth mouse mammary tumor genetically engineered clostridia luminous bacterial symbiont privacy choices/manage cookies hyun-ju kim young-kyu park colon cancer cells gene delivery system molecular imaging tumour-targeting vectors metastatic process defined salmonella typhimurium bioluminescence signals vivo imaging platelet-activating factor jain rk article min tumor-targeting tumor targeting cancer gene therapy european economic area jae hyo park jae ho jeong yeoung-jin hong combination bacteriolytic therapy amino acid auxotrophs

Questions {❓}

  • Jain RK, Forbes NS (2001) Can engineered bacteria help control cancer?

Schema {🗺️}

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         headline:Noninvasive Real-time Imaging of Tumors and Metastases Using Tumor-targeting Light-emitting Escherichia coli
         description:A number of bacteria types are known to preferentially grow in tumors. We have taken advantage of this phenomenon to target luciferase-expressing Escherichia coli to tumors and metastases in mouse models to image them noninvasively. After intravenous injection of pLux-expressing E. coli (108 CFU), bioluminescence signals from the bacteria were detected exclusively in tumor tissue after 24 hours. The balanced-lethal host–vector system using the gene encoding aspartate β-semialdehyde dehydrogenase (asd) enabled stable maintenance of the pLux in the tumor-targeting E. coli. This phenomenon of selective tumor targeting and proliferation of E. coli was observed in a diverse range of tumors implanted in nude mice. More importantly, E. coli was capable of targeting both primary tumors and metastases, enabling them to be imaged noninvasively in both nude and immunocompetent mice. Our results suggest the potential clinical use of this technology for tumor targeting.
         datePublished:2007-11-10T00:00:00Z
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            Tumor imaging
            Noninvasive small animal imaging
             Escherichia coli
            Bacterial luciferase (Lux)
            Green fluorescent protein (GFP)
            Cancer-targeting bacteria
            Imaging / Radiology
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      headline:Noninvasive Real-time Imaging of Tumors and Metastases Using Tumor-targeting Light-emitting Escherichia coli
      description:A number of bacteria types are known to preferentially grow in tumors. We have taken advantage of this phenomenon to target luciferase-expressing Escherichia coli to tumors and metastases in mouse models to image them noninvasively. After intravenous injection of pLux-expressing E. coli (108 CFU), bioluminescence signals from the bacteria were detected exclusively in tumor tissue after 24 hours. The balanced-lethal host–vector system using the gene encoding aspartate β-semialdehyde dehydrogenase (asd) enabled stable maintenance of the pLux in the tumor-targeting E. coli. This phenomenon of selective tumor targeting and proliferation of E. coli was observed in a diverse range of tumors implanted in nude mice. More importantly, E. coli was capable of targeting both primary tumors and metastases, enabling them to be imaged noninvasively in both nude and immunocompetent mice. Our results suggest the potential clinical use of this technology for tumor targeting.
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      pageEnd:61
      sameAs:https://doi.org/10.1007/s11307-007-0120-5
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         Tumor imaging
         Noninvasive small animal imaging
          Escherichia coli
         Bacterial luciferase (Lux)
         Green fluorescent protein (GFP)
         Cancer-targeting bacteria
         Imaging / Radiology
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                     type:PostalAddress
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            name:Sungmin Moon
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                  address:
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            name:Yeoung-Jin Hong
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                  name:Chonnam National University Medical School
                  address:
                     name:Department of Microbiology, Chonnam National University Medical School, Gwangju, South Korea
                     type:PostalAddress
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            name:Kyoung-Oh Cho
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                  name:Chonnam National University College of Veterinary Medicine
                  address:
                     name:Department of Pathology, Chonnam National University College of Veterinary Medicine, Gwangju, South Korea
                     type:PostalAddress
                  type:Organization
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            name:Jong Hee Nam
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                  name:Chonnam National University Medical School
                  address:
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            name:Nacksung Kim
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                  address:
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            name:Hyon E. Choy
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      name:Yeoung-Jin Hong
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               type:PostalAddress
            type:Organization
      name:Jong Hee Nam
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            name:Chonnam National University Medical School
            address:
               name:Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea
               type:PostalAddress
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      name:Nacksung Kim
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            name:Chonnam National University Medical School
            address:
               name:Department of Pharmacology, Chonnam National University Medical School, Gwangju, South Korea
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      name:Hee-Seung Bom
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            address:
               name:Laboratory of In Vivo Molecular Imaging, Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju, South Korea
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      name:Joon Haeng Rhee
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            address:
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               type:PostalAddress
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      name:Hyon E. Choy
      affiliation:
            name:Chonnam National University Medical School
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               name:Department of Microbiology, Chonnam National University Medical School, Gwangju, South Korea
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      name:Laboratory of In Vivo Molecular Imaging, Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju, South Korea
      name:Department of Microbiology, Chonnam National University Medical School, Gwangju, South Korea
      name:Department of Microbiology, Chonnam National University Medical School, Gwangju, South Korea
      name:Department of Pathology, Chonnam National University College of Veterinary Medicine, Gwangju, South Korea
      name:Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea
      name:Department of Pharmacology, Chonnam National University Medical School, Gwangju, South Korea
      name:Department of Surgery, Chonnam National University Medical School, Gwangju, South Korea
      name:Laboratory of In Vivo Molecular Imaging, Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju, South Korea
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      name:Department of Microbiology, Chonnam National University Medical School, Gwangju, South Korea
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External Links {🔗}(131)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

3.79s.