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Title:
ATP synthesis and storage | Purinergic Signalling
Description:
Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.
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Keywords {🔍}
google, scholar, pubmed, cas, atp, cell, biol, mitochondrial, kinase, calcium, cells, chem, biochem, protein, mitochondria, regulation, physiol, signalling, article, role, metabolism, mol, dehydrogenase, ampactivated, extracellular, synthase, res, heart, research, purinergic, storage, phosphorylation, biophys, rat, energy, metabolic, mammalian, acta, pyruvate, sci, synthesis, biochim, nature, isolated, usa, ampk, cardiac, adenosine, apoptosis, activity,
Topics {✒️}
month download article/chapter amp-activated protein kinase agonist-sensitive internal store aptamer-based receptor molecules ecto-nucleotide kinase activities oxidative post-translational modification label-free dna aptamer f0f1-atpase/atp synthase long-term metabolic priming acetyl-coa carboxylase kinase guinea-pig urinary bladder creatine kinase-deficient mice lymphoid ecto-adenylate kinase camp-dependent tyrosine phosphorylation oxidized nicotinamide-adenine dinucleotide mitochondrial f1-atpase activity nad+-linked isocitrate dehydrogenase mitochondrial atp synthesis mammalian glyceraldehyde-3-phosphate dehydrogenase related subjects 2-oxoglutarate dehydrogenase complex sonia missiroli cardiac excitation-contraction coupling training fellowship fism-cod purinergic signalling cascade full article pdf mitochondrial atp synthase nad+-dependent signalling cholesterol loading increases paolo pinton activated human monocytes privacy choices/manage cookies atp synthase catalysis camp-dependent phosphorylation atp-mediated glia signaling mitochondrial calcium uniporter bacterial intracellular amp isolated ventricular myocytes calcium signalling events atp production linked atp synthesis temporal profile guinea-pig cochlea mitochondrial carrier superfamily forty-kilodalton protein succinyl–coa synthetases ca2+-dependent inactivation intercellular calcium waves mitochondrial calcium uptake purinergic signalling mechanisms
Questions {❓}
- Hardie DG, Carling D (1997) The AMP-activated protein kinase–fuel gauge of the mammalian cell?
- White PN et al (1995) Quinacrine staining of marginal cells in the stria vascularis of the guinea-pig cochlea: a possible source of extracellular ATP?
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headline:ATP synthesis and storage
description:Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.
datePublished:2012-04-12T00:00:00Z
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ATP synthesis
ATP storage
Mitochondria
Calcium
Biomedicine
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description:Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.
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ATP storage
Mitochondria
Calcium
Biomedicine
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Human Physiology
Neurosciences
Cancer Research
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