We are analyzing https://link.springer.com/article/10.1007/s11302-005-5302-5.

Title:
Physiological roles for ecto-5’-nucleotidase (CD73) | Purinergic Signalling
Description:
Nucleotides and nucleosides influence nearly every aspect of physiology and pathophysiology. Extracellular nucleotides are metabolized through regulated phosphohydrolysis by a series of ecto-nucleotidases. The formation of extracellular adenosine from adenosine 5’-monophosphate is accomplished primarily through ecto-5’-nucleotidase (CD73), a glycosyl phosphatidylinositol-linked membrane protein found on the surface of a variety of cell types. Recent in vivo studies implicating CD73 in a number of tissue protective mechanisms have provided new insight into its regulation and function and have generated considerable interest. Here, we review contributions of CD73 to cell and tissue stress responses, with a particular emphasis on physiologic responses to regulated CD73 expression and function, as well as new findings utilizing Cd73-deficient animals.
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Keywords {🔍}

google, scholar, pubmed, cas, article, adenosine, physiol, endothelial, cell, hypoxia, med, role, vascular, clin, ectonucleotidase, invest, function, exp, cells, eltzschig, colgan, receptors, biol, signalling, expression, human, nucleotide, factor, circ, content, research, access, res, privacy, cookies, purinergic, thompson, extracellular, regulation, cancer, nucleotidase, biochem, rev, pharmacol, receptor, blood, atp, hypoxiainducible, hif, publish,

Topics {✒️}

aspirin-triggered 15-epi-lipoxin a4 month download article/chapter recombinant soluble ecto-adpase/cd39 neutrophil-derived paracrine factor requires ecto-5’-nucleotidase-mediated conversion hypoxia-inducible factor-1 alpha cd73/ecto-5’-nucleotidase alters thromboregulation ecto-5’-nucleotidase/cd73-deficient mice epithelial hypoxia-inducible factor-1 electroneutral cation-chloride cotransporters ecto-5’-nucleotidase/cd73-dependent mechanism substrate binding modes soluble ecto-enzymes atpase human b-cell line related subjects increased ecto-5’-nucleotidase activity promotes lung metastases full article pdf extracellular nucleotide metabolism hypoxia-inducible factor-1 hypoxia-inducible factor neutrophil inflammatory response dynamic purine signalling human intestinal epithelia neutrophil-endothelial interactions cd39/atp diphosphohydrolase results endothelial cell activation nucleotide] triphosphate diphosphohydrolase-1 follicular dendritic cells privacy choices/manage cookies purinergic signalling 2005 purinergic signalling 2 vascular cell proliferation vascular endothelial cells regulatory molecules p2y1-deficient mice host cell killing cd73-mediated conversion human ecto-5′-nucleotidase cell surface expression receptor-mediated mechanisms occlusive vascular diseases common human diseases elicits chloride secretion increased bleeding time cytomegalovirus infection increases harvard medical school intensive care medicine endothelial junctional permeability ischemic vascular diseases

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         datePublished:2006-06-01T00:00:00Z
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            Cancer Research
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      headline:Physiological roles for ecto-5’-nucleotidase (CD73)
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         hypoxia
         inflammation
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         Neurosciences
         Cancer Research
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