
LINK . SPRINGER . COM {
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Title:
Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications | Reviews in Endocrine and Metabolic Disorders
Description:
Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.
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Topics {โ๏ธ}
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Questions {โ}
- Are ACE-inhibitors a โmagic bulletโ against oxidative stress?
- Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome?
- Endothelial function: A barometer for cardiovascular risk?
- Endothelial โstunningโ following a brief exposure to endotoxin: a mechanism to link infection and infarction?
- Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?
- Reversing endothelial dysfunction with ACE inhibitors: a new trend?
- Shear-stress-mediated arterial remodeling in atherosclerosis: too much of a good thing?
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description:Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.
datePublished:2010-02-26T00:00:00Z
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Diabetes mellitus
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Protein kinase C
Endocrinology
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