We are analyzing https://link.springer.com/article/10.1007/s11154-007-9041-5.

Title:
Deciphering the molecular basis of breast cancer metastasis with mouse models | Reviews in Endocrine and Metabolic Disorders
Description:
Breast cancer begins as a localized disease, but has the potential to spread to distant sites within the body. This process—known as metastasis—is the leading cause of death from breast cancer. Whether the ability of cancer cells to metastasize is an intrinsic or acquired feature is currently a topic of considerable debate. Nevertheless, the key cellular events required for metastasis are generally accepted. These include invasion of the surrounding stromal tissue, intravasation, evasion of programmed cell death, arrest within the vasculature at a distant site, extravasation, and establishment and growth within a new microenvironment. The development of mouse models that faithfully mimic critical aspects of human neoplasia has been instrumental in framing our current understanding of multistage carcinogenesis. This review examines the advantages and limitations of existing murine models for mammary carcinogenesis for probing the molecular mechanisms that contribute to metastasis, as well as non-invasive tumor imaging approaches to facilitate these investigations.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

google, scholar, pubmed, cas, article, cancer, cell, breast, tumor, metastasis, mammary, res, cells, matrix, biol, expression, mice, human, adhesion, metalloproteinase, progression, transgenic, carcinoma, mouse, invasion, development, molecule, imaging, metastatic, metalloproteinases, models, oncogene, tumors, growth, pathol, model, vivo, plasminogen, activator, stromal, med, sci, tumorigenesis, nat, gene, angiogenesis, neoplasia, induces, ecadherin, muller,

Topics {✒️}

cytokine-regulated urokinase-type-plasminogen-activator neu/erbb2-induced mammary tumors month download article/chapter mmtv/v-ha-ras hypoxia-inducible factor-1alpha beta-catenin/lef-1 pathway cell-cell adhesion molecule antigen-induced mammary cancer extracellular signal-regulated kinase urokinase-type plasminogen activator tumor-induced host response stetler-stevenson wg n-cadherin promotes motility adhesion molecule l1 tumor–host cell communication mmtv/c-myc genes intra-peritoneal tumor growth cut loose-disintegrin metalloproteases low-molecular-weight heparin tumor cell-platelet interaction bone-related genes expressed human ha-ras oncogene long-standing aspartic protease noninvasive real-time imaging beta-catenin signaling urokinase receptor antibody early mammary tumorigenesis full article pdf combined upa gene-disrupted gelatinase a-deficient mice int-2 proto-oncogenes cooperate tumor cell migration urokinase plasminogen activator lymph node status privacy choices/manage cookies cell adhesion molecules collagen type iv henzen-logmans sc anti-human procathepsin adam family members reconstituted basement membrane adhesion-independent mechanism cea adhesion molecules epithelial tumor cells plasminogen-deficient mice transgenic mammary cancer primary mammary cultures mammary gland development epithelial–stromal interactions inhibits tumor progression

Questions {❓}

CEACAM1: a marker with a difference or more of the same?
Models of breast cancer: is merging human and animal models the future?
Proteases and metastasis: clinical relevance nowadays?
State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Deciphering the molecular basis of breast cancer metastasis with mouse models
         description:Breast cancer begins as a localized disease, but has the potential to spread to distant sites within the body. This process—known as metastasis—is the leading cause of death from breast cancer. Whether the ability of cancer cells to metastasize is an intrinsic or acquired feature is currently a topic of considerable debate. Nevertheless, the key cellular events required for metastasis are generally accepted. These include invasion of the surrounding stromal tissue, intravasation, evasion of programmed cell death, arrest within the vasculature at a distant site, extravasation, and establishment and growth within a new microenvironment. The development of mouse models that faithfully mimic critical aspects of human neoplasia has been instrumental in framing our current understanding of multistage carcinogenesis. This review examines the advantages and limitations of existing murine models for mammary carcinogenesis for probing the molecular mechanisms that contribute to metastasis, as well as non-invasive tumor imaging approaches to facilitate these investigations.
         datePublished:2007-07-27T00:00:00Z
         dateModified:2007-07-27T00:00:00Z
         pageStart:199
         pageEnd:213
         sameAs:https://doi.org/10.1007/s11154-007-9041-5
         keywords:
            Breast cancer
            Metastasis
            Animal models
            Endocrinology
            Diabetes
            Internal Medicine
         image:
         isPartOf:
            name:Reviews in Endocrine and Metabolic Disorders
            issn:
               1573-2606
               1389-9155
            volumeNumber:8
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ann E. Vernon
               affiliation:
                     name:University of Pennsylvania School of Medicine
                     address:
                        name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Suzanne J. Bakewell
               affiliation:
                     name:University of Pennsylvania School of Medicine
                     address:
                        name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lewis A. Chodosh
               affiliation:
                     name:University of Pennsylvania School of Medicine
                     address:
                        name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Deciphering the molecular basis of breast cancer metastasis with mouse models
      description:Breast cancer begins as a localized disease, but has the potential to spread to distant sites within the body. This process—known as metastasis—is the leading cause of death from breast cancer. Whether the ability of cancer cells to metastasize is an intrinsic or acquired feature is currently a topic of considerable debate. Nevertheless, the key cellular events required for metastasis are generally accepted. These include invasion of the surrounding stromal tissue, intravasation, evasion of programmed cell death, arrest within the vasculature at a distant site, extravasation, and establishment and growth within a new microenvironment. The development of mouse models that faithfully mimic critical aspects of human neoplasia has been instrumental in framing our current understanding of multistage carcinogenesis. This review examines the advantages and limitations of existing murine models for mammary carcinogenesis for probing the molecular mechanisms that contribute to metastasis, as well as non-invasive tumor imaging approaches to facilitate these investigations.
      datePublished:2007-07-27T00:00:00Z
      dateModified:2007-07-27T00:00:00Z
      pageStart:199
      pageEnd:213
      sameAs:https://doi.org/10.1007/s11154-007-9041-5
      keywords:
         Breast cancer
         Metastasis
         Animal models
         Endocrinology
         Diabetes
         Internal Medicine
      image:
      isPartOf:
         name:Reviews in Endocrine and Metabolic Disorders
         issn:
            1573-2606
            1389-9155
         volumeNumber:8
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ann E. Vernon
            affiliation:
                  name:University of Pennsylvania School of Medicine
                  address:
                     name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Suzanne J. Bakewell
            affiliation:
                  name:University of Pennsylvania School of Medicine
                  address:
                     name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lewis A. Chodosh
            affiliation:
                  name:University of Pennsylvania School of Medicine
                  address:
                     name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Reviews in Endocrine and Metabolic Disorders
      issn:
         1573-2606
         1389-9155
      volumeNumber:8
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Pennsylvania School of Medicine
      address:
         name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:University of Pennsylvania School of Medicine
      address:
         name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:University of Pennsylvania School of Medicine
      address:
         name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ann E. Vernon
      affiliation:
            name:University of Pennsylvania School of Medicine
            address:
               name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Suzanne J. Bakewell
      affiliation:
            name:University of Pennsylvania School of Medicine
            address:
               name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Lewis A. Chodosh
      affiliation:
            name:University of Pennsylvania School of Medicine
            address:
               name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
      name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
      name:Departments of Cancer Biology, Cell & Developmental Biology, and Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(582)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Foundation
Prism.js

CDN Services {📦}

Crossref

5.27s.

LINK . SPRINGER . COM {}