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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

• Does propofol have advantages over isoflurane for sufentanil supplemented anesthesia in children for strabismus surgery?

Schema {🗺️}

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         headline:Efficacy and safety of ciprofol versus propofol for the induction of anesthesia in adult patients: a multicenter phase 2a clinical trial
         description:Ciprofol is a novel 2, 6-disubstituted phenolic derivative anesthetic that binds to the gamma-aminobutyric acid-A receptor. To determine the equally potent dose of ciprofol compared with propofol as an induction agent for general anesthesia in patients undergoing selective surgery, and to assess its safety. A total of 109 patients undergoing selective non-emergency, non-cardiothoracic or non-neurosurgical surgery requiring tracheal intubation for general anesthesia were enrolled. Ten patients per group were assigned to ciprofol-0.3, 0.4 and 0.5 mg/kg, and propofol-2.0 or 2.5 mg/kg groups, respectively to receive an intravenous bolus dose. An additional 20 patients were enrolled in the ciprofol-0.3, 0.5 or propofol-2.0 mg/kg groups. The primary outcome was the success rate of induction defined as a Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) ≤ 1 after the initial bolus dose. The secondary outcomes included the time to reach MOAA/S ≤ 1, the time to loss of the eyelash reflex, the incidences and severity of adverse events (AEs). The success rates were 100% for all 5 groups. The mean time to MOAA/S ≤ 1 and the time to loss of the eyelash reflex were not different among the 5 groups, regardless of whether a top-up dose was needed. There were no significant differences in the incidences and severity of AEs in the dose ranges investigated of ciprofol vs. propofol. The efficacy and safety of a single bolus dose of ciprofol-0.5 mg/kg for the general anesthesia induction in selective surgery patients was comparable to that of propofol-2.0 mg/kg. Clinicaltrials.gov, NCT03698617, retrospectively registered.
         datePublished:2023-01-21T00:00:00Z
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      headline:Efficacy and safety of ciprofol versus propofol for the induction of anesthesia in adult patients: a multicenter phase 2a clinical trial
      description:Ciprofol is a novel 2, 6-disubstituted phenolic derivative anesthetic that binds to the gamma-aminobutyric acid-A receptor. To determine the equally potent dose of ciprofol compared with propofol as an induction agent for general anesthesia in patients undergoing selective surgery, and to assess its safety. A total of 109 patients undergoing selective non-emergency, non-cardiothoracic or non-neurosurgical surgery requiring tracheal intubation for general anesthesia were enrolled. Ten patients per group were assigned to ciprofol-0.3, 0.4 and 0.5 mg/kg, and propofol-2.0 or 2.5 mg/kg groups, respectively to receive an intravenous bolus dose. An additional 20 patients were enrolled in the ciprofol-0.3, 0.5 or propofol-2.0 mg/kg groups. The primary outcome was the success rate of induction defined as a Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) ≤ 1 after the initial bolus dose. The secondary outcomes included the time to reach MOAA/S ≤ 1, the time to loss of the eyelash reflex, the incidences and severity of adverse events (AEs). The success rates were 100% for all 5 groups. The mean time to MOAA/S ≤ 1 and the time to loss of the eyelash reflex were not different among the 5 groups, regardless of whether a top-up dose was needed. There were no significant differences in the incidences and severity of AEs in the dose ranges investigated of ciprofol vs. propofol. The efficacy and safety of a single bolus dose of ciprofol-0.5 mg/kg for the general anesthesia induction in selective surgery patients was comparable to that of propofol-2.0 mg/kg. Clinicaltrials.gov, NCT03698617, retrospectively registered.
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      dateModified:2023-01-21T00:00:00Z
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         Anesthesia
         Ciprofol
         Propofol
         Sedation
         Tracheal intubation
         Internal Medicine
         Pharmacy
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               type:PostalAddress
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      name:Wensheng Zhang
      affiliation:
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            address:
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               type:PostalAddress
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      name:Yunxia Zuo
      affiliation:
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            address:
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               type:PostalAddress
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      name:Xiao Wang
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               type:PostalAddress
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      email:[email protected]
      name:Jin Liu
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            address:
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      name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Anesthesiology, Peking University First Hospital, Beijing, China
      name:Department of Anesthesiology, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
      name:Department of Anesthesiology, Sichuan Provincial People’s Hospital, Chengdu, China
      name:Department of Anesthesiology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
      name:Department of Anesthesiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
      name:Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, China
      name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China

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