We are analyzing https://link.springer.com/article/10.1007/s11095-010-0233-4.

Title:
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release | Pharmaceutical Research
Description:
Micelles are colloidal particles with a size around 5–100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet’ a major step forward.
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

How can azobenzene block copolymer vesicles be dissociated and reformed by light?

Schema {🗺️}

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         headline:Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
         description:Micelles are colloidal particles with a size around 5–100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet’ a major step forward.
         datePublished:2010-08-20T00:00:00Z
         dateModified:2010-08-20T00:00:00Z
         pageStart:2569
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ScholarlyArticle:
      headline:Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
      description:Micelles are colloidal particles with a size around 5–100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet’ a major step forward.
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      dateModified:2010-08-20T00:00:00Z
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         imaging
         micelles
         nanomedicine
         theranostics
         triggered release
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         Pharmacy
         Biochemistry
         general
         Medical Law
         Biomedical Engineering and Bioengineering
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