We are analyzing https://link.springer.com/article/10.1007/s11095-010-0089-7.

Title:
Apigenin: A Promising Molecule for Cancer Prevention | Pharmaceutical Research
Description:
Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process, such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.
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Keywords {🔍}

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Topics {✒️}

apigenin-induced cell-cycle arrest phosphatidylinositol 3-kinase/akt-dependent pathway estrogen receptor-alpha-independent mechanisms month download article/chapter nf-kappab-responsive genes human p-form phenolsulfotransferase estrogen receptor-alpha-dependent van dross rt g1 cell-cycle arrest hplc-tandem mass spectrometry reverse-phase protein microarrays cell-signaling pathways modulator estrogen receptor binding-dependent focal adhesion kinase collins-burow bm modulating cyclin-cdk regulators wild-type p53 stability van der heide tnf-alpha-mediated apoptosis enhanced anti-tumor effect breast carcinoma cells pkc-mediated survival signaling chemopreventive bioflavonoid apigenin caspase-calpain-dependent pathways activate er alpha cyclooxygenase-mediated prostaglandin production p53-independent pathway apigenin inhibits proliferation full article pdf na+/ca2+ exchanger inducing hif-1alpha degradation human prostate cancer prostate cancer chemoprevention arachidonic acid pathway apigenin inhibits growth public health nutr cell cycle arrest cell-cycle arrest signal pathways involved nuclear factor-kappa human leukemia cells p53-dependent pathway colon cancer cells human epithelial cells apigenin inhibits vegf cell-cycle deregulatory cell cycle progression article shukla o'leary jj prostate epithelial cells

Questions {❓}

Cancer in the elderly: is it preventable?
Flavonoids: antioxidants or signalling molecules?

Schema {🗺️}

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