We are analyzing https://link.springer.com/article/10.1007/s11095-007-9289-1.

Title:
Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications | Pharmaceutical Research
Description:
Specific transporters expressed in the liver and the intestine, play a critical role in driving the enterohepatic circulation of bile acids. By preserving a circulating pool of bile acids, an important factor influencing bile flow, these transporters are involved in maintaining bile acid and cholesterol homeostasis. Enterohepatic circulation of bile acids is fundamentally composed of two major processes: secretion from the liver and absorption from the intestine. In the hepatocytes, the vectorial transport of bile acids from blood to bile is ensured by Na+ taurocholate co-transporting peptide (NTCP) and organic anion transport polypeptides (OATPs). After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs). Bile acids are then delivered to the intestinal lumen through bile ducts where they emulsify dietary lipids and cholesterol to facilitate their absorption. Intestinal epithelial cells reabsorb the majority of the secreted bile acids through the apical sodium dependent bile acid transporter (ASBT) and sodium independent organic anion transporting peptide (OATPs). Cytosolic ileal bile acid binding protein (IBABP) mediates the transcellular movement of bile acids to the basolateral membrane across which they exit the cells via organic solute transporters (OST). An essential role of bile acid transporters is evident from the pathology associated with their genetic disruption or dysregulation of their function. Malfunctioning of hepatic and intestinal bile acid transporters is implicated in the pathophysiology of cholestatic liver disease and the depletion of circulating pool of bile acids, respectively. Extensive efforts have been recently made to enhance our understanding of the structure, function and regulation of the bile acid transporters and exploring new potential therapeutics to treat bile acid or cholesterol related diseases. This review will highlight current knowledge about structure, function and molecular characterization of bile acid transporters and discuss the implications of their defects in various hepatic and intestinal disorders.
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Keywords {🔍}

google, scholar, pubmed, cas, bile, acid, transporter, transport, rat, liver, human, physiol, ileal, biol, chem, acids, organic, expression, sodiumdependent, transporters, salt, meier, gene, membrane, regulation, protein, hepatic, gastroenterology, anion, apical, characterization, hepatology, dawson, shneider, function, intestinal, cholestasis, hagenbuch, ananthanarayanan, cholesterol, taurocholate, suchy, receptor, stieger, polypeptide, molecular, kullakublick, res, pump, nuclear,

Topics {✒️}

sodium-dependent taurocholate uptake organic anion-transporting polypeptide ileal brush-border membrane peroxisome proliferator-activated receptors month download article/chapter bile acid-binding polypeptides bile acid-responsive element bile acid-mts conjugates ca2+-dependent cell death ileal lipid-binding protein na+-taurocholate cotransporting polypeptide na+/taurocholate cotransporting polypeptide na+-bile acid cotransport na+-dependent taurocholate uptake human niemann-pick c1 receptor/bile acid receptor bile acid-binding site estradiol 17beta-d-glucuronide bile acid cotransporter interleukin-1 beta-mediated suppression oatp1-mediated tubular reabsorption hepatocyte nuclear factor-1alpha p-type atpase mutated bile salt cotransporter bile acid binding /bile acid cotransporters bile acid transporters organic solute transporters bile salt transporters bile acid uptake reduces hepatic steatosis hepatocellular bile acid taurocholate cotransporting polypeptide c-fos nuclear translocation bile acid transport maintaining bile acid treat bile acid bile acid synthesis bile acid diarrhea bile acid derivative conjugated bile acid bile acid interactions mediate organic solute site-specific binding rat ileal enterocytes ileal basolateral membrane apical membrane sorting cas google scholar pubmed google scholar 14-amino acid sequence

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         description:Specific transporters expressed in the liver and the intestine, play a critical role in driving the enterohepatic circulation of bile acids. By preserving a circulating pool of bile acids, an important factor influencing bile flow, these transporters are involved in maintaining bile acid and cholesterol homeostasis. Enterohepatic circulation of bile acids is fundamentally composed of two major processes: secretion from the liver and absorption from the intestine. In the hepatocytes, the vectorial transport of bile acids from blood to bile is ensured by Na+ taurocholate co-transporting peptide (NTCP) and organic anion transport polypeptides (OATPs). After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs). Bile acids are then delivered to the intestinal lumen through bile ducts where they emulsify dietary lipids and cholesterol to facilitate their absorption. Intestinal epithelial cells reabsorb the majority of the secreted bile acids through the apical sodium dependent bile acid transporter (ASBT) and sodium independent organic anion transporting peptide (OATPs). Cytosolic ileal bile acid binding protein (IBABP) mediates the transcellular movement of bile acids to the basolateral membrane across which they exit the cells via organic solute transporters (OST). An essential role of bile acid transporters is evident from the pathology associated with their genetic disruption or dysregulation of their function. Malfunctioning of hepatic and intestinal bile acid transporters is implicated in the pathophysiology of cholestatic liver disease and the depletion of circulating pool of bile acids, respectively. Extensive efforts have been recently made to enhance our understanding of the structure, function and regulation of the bile acid transporters and exploring new potential therapeutics to treat bile acid or cholesterol related diseases. This review will highlight current knowledge about structure, function and molecular characterization of bile acid transporters and discuss the implications of their defects in various hepatic and intestinal disorders.
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