We are analyzing https://link.springer.com/article/10.1007/s11064-020-03035-w.

Title:
LncRNA H19 Attenuates Apoptosis in MPTP-Induced Parkinson’s Disease Through Regulating miR-585-3p/PIK3R3 | Neurochemical Research
Description:
Parkinson’s disease (PD) is a prevalent age-related neurodegenerative disease which is modulated by various molecules, including long non-coding RNAs (lncRNAs). LncRNA H19 has been shown to be associated with PD progression, but the mechanism is still unclear. This research aims to investigate the role of H19 in PD development and the detailed mechanisms. Our results showed that H19 was down-regulated in brain tissue of MPTP-induced PD mice (in vivo) and in MPP+ treated human neuroblastoma cells. miR-585-3p was verified to be a target of lncRNA H19 and was negatively regulated by H19. In addition, H19 could increase the expression of PIK3R3 through miR-585-3p. In vitro results indicated that H19 inhibited the apoptosis of MPP+ treated neuroblastoma cells by regulating of miR-585-3p. Moreover, in PD model mice, overexpression of H19 attenuated MPTP-induced neuronal apoptosis. In summary, our present research demonstrated that LncRNA H19 could attenuate neurons apoptosis in MPTP-induced PD mice as well as MPP+ treated neuroblastoma cells through regulating miR-585-3p/PIK3R3. The results may provide a potential theoretical experimental data for the clinical treatment of PD through targeting lncRNAs or miRNAs.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

article, google, scholar, disease, parkinsons, cas, pubmed, lncrna, noncoding, data, research, apoptosis, zhang, long, rna, httpsdoiorgs, mptpinduced, rnas, privacy, cookies, content, mice, information, publish, search, regulating, published, april, lin, results, cells, mirp, expression, access, wang, res, nature, springer, log, journal, mirppikr, xia, jun, brain, mpp, treated, neuroblastoma, discover, liu, cancer,

Topics {✒️}

month download article/chapter mpp+ treated neuroblastoma cells regulating mir-585-3p/pik3r3 small-cell lung cancer mptp-induced pd mice long noncoding rnas present research demonstrated full article pdf privacy choices/manage cookies jun lin attenuate neurons apoptosis related subjects long guo y long-lived mice biochim biophys acta chronic mptp protocol published article mptp-induced parkinson research aims superoxide dismutase coding european economic area stabilizing pink1 protein multivessel coronary spasm zhongshang east road ethics declarations conflict animal ethics committee conditions privacy policy pd model mice gene regul mech modeling pd pathogenesis primary microrna precursor accepting optional cookies additional information publisher' article log article zhang author information authors journal finder publish mir-585-3p article cite preliminary report personal data cell apoptosis lncrna h19 including long kagakuhyoronsha publishing authors state fu w coding rnas check access instant access

Schema {🗺️}

WebPage:
      mainEntity:
         headline:LncRNA H19 Attenuates Apoptosis in MPTP-Induced Parkinson’s Disease Through Regulating miR-585-3p/PIK3R3
         description:Parkinson’s disease (PD) is a prevalent age-related neurodegenerative disease which is modulated by various molecules, including long non-coding RNAs (lncRNAs). LncRNA H19 has been shown to be associated with PD progression, but the mechanism is still unclear. This research aims to investigate the role of H19 in PD development and the detailed mechanisms. Our results showed that H19 was down-regulated in brain tissue of MPTP-induced PD mice (in vivo) and in MPP+ treated human neuroblastoma cells. miR-585-3p was verified to be a target of lncRNA H19 and was negatively regulated by H19. In addition, H19 could increase the expression of PIK3R3 through miR-585-3p. In vitro results indicated that H19 inhibited the apoptosis of MPP+ treated neuroblastoma cells by regulating of miR-585-3p. Moreover, in PD model mice, overexpression of H19 attenuated MPTP-induced neuronal apoptosis. In summary, our present research demonstrated that LncRNA H19 could attenuate neurons apoptosis in MPTP-induced PD mice as well as MPP+ treated neuroblastoma cells through regulating miR-585-3p/PIK3R3. The results may provide a potential theoretical experimental data for the clinical treatment of PD through targeting lncRNAs or miRNAs.
         datePublished:2020-04-30T00:00:00Z
         dateModified:2020-04-30T00:00:00Z
         pageStart:1700
         pageEnd:1710
         sameAs:https://doi.org/10.1007/s11064-020-03035-w
         keywords:
            LncRNA H19
            Parkinson's disease
            miR-585-3p
            PIK3R3
            Neurosciences
            Neurochemistry
            Biochemistry
            general
            Cell Biology
            Neurology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig7_HTML.png
         isPartOf:
            name:Neurochemical Research
            issn:
               1573-6903
               0364-3190
            volumeNumber:45
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yong Zhang
               affiliation:
                     name:Guizhou People’s Hospital
                     address:
                        name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qiming Xia
               affiliation:
                     name:Guizhou People’s Hospital
                     address:
                        name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jun Lin
               url:http://orcid.org/0000-0002-7157-2554
               affiliation:
                     name:Guizhou People’s Hospital
                     address:
                        name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:LncRNA H19 Attenuates Apoptosis in MPTP-Induced Parkinson’s Disease Through Regulating miR-585-3p/PIK3R3
      description:Parkinson’s disease (PD) is a prevalent age-related neurodegenerative disease which is modulated by various molecules, including long non-coding RNAs (lncRNAs). LncRNA H19 has been shown to be associated with PD progression, but the mechanism is still unclear. This research aims to investigate the role of H19 in PD development and the detailed mechanisms. Our results showed that H19 was down-regulated in brain tissue of MPTP-induced PD mice (in vivo) and in MPP+ treated human neuroblastoma cells. miR-585-3p was verified to be a target of lncRNA H19 and was negatively regulated by H19. In addition, H19 could increase the expression of PIK3R3 through miR-585-3p. In vitro results indicated that H19 inhibited the apoptosis of MPP+ treated neuroblastoma cells by regulating of miR-585-3p. Moreover, in PD model mice, overexpression of H19 attenuated MPTP-induced neuronal apoptosis. In summary, our present research demonstrated that LncRNA H19 could attenuate neurons apoptosis in MPTP-induced PD mice as well as MPP+ treated neuroblastoma cells through regulating miR-585-3p/PIK3R3. The results may provide a potential theoretical experimental data for the clinical treatment of PD through targeting lncRNAs or miRNAs.
      datePublished:2020-04-30T00:00:00Z
      dateModified:2020-04-30T00:00:00Z
      pageStart:1700
      pageEnd:1710
      sameAs:https://doi.org/10.1007/s11064-020-03035-w
      keywords:
         LncRNA H19
         Parkinson's disease
         miR-585-3p
         PIK3R3
         Neurosciences
         Neurochemistry
         Biochemistry
         general
         Cell Biology
         Neurology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11064-020-03035-w/MediaObjects/11064_2020_3035_Fig7_HTML.png
      isPartOf:
         name:Neurochemical Research
         issn:
            1573-6903
            0364-3190
         volumeNumber:45
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yong Zhang
            affiliation:
                  name:Guizhou People’s Hospital
                  address:
                     name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qiming Xia
            affiliation:
                  name:Guizhou People’s Hospital
                  address:
                     name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jun Lin
            url:http://orcid.org/0000-0002-7157-2554
            affiliation:
                  name:Guizhou People’s Hospital
                  address:
                     name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Neurochemical Research
      issn:
         1573-6903
         0364-3190
      volumeNumber:45
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Guizhou People’s Hospital
      address:
         name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
         type:PostalAddress
      name:Guizhou People’s Hospital
      address:
         name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
         type:PostalAddress
      name:Guizhou People’s Hospital
      address:
         name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yong Zhang
      affiliation:
            name:Guizhou People’s Hospital
            address:
               name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
               type:PostalAddress
            type:Organization
      name:Qiming Xia
      affiliation:
            name:Guizhou People’s Hospital
            address:
               name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
               type:PostalAddress
            type:Organization
      name:Jun Lin
      url:http://orcid.org/0000-0002-7157-2554
      affiliation:
            name:Guizhou People’s Hospital
            address:
               name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
      name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
      name:Department of Neurosurgery, Guizhou People’s Hospital, Guiyang, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(96)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.95s.

LINK . SPRINGER . COM {}